“…The Alvarado score discriminated well as an observation/admission criterion (cut point of 5) by achieving high pooled sensitivity of 99% overall (n = 28 studies, [5,8,10,) and in studies where data were available, it also performed well in the subgroup analysis for men, woman and children (pooled sensitivities: 0.96 for men, n = 5 [23,30,[33][34][35]; 0.99 for women, n = 5 [23,30,34,35,43] and 0.99 for children, n = 9 [10,21,23,27,28,30,[40][41][42]) ( Table 2 and Additional file 1 - Figure S1). In patients presenting with higher Alvarado scores (cut point of 7, the criterion for surgery), pooled diagnostic accuracy results had more limited clinical value (pooled specificity for all studies 0.82, n = 29, [5,8,10,11,[18][19][20][21][22][23][24][25][27][28][29][30][31][32][34][35][36]…”