Alveolar gas exchange and tissue deoxygenation during exercise in type 1 diabetes patients and healthy controls

Peltonen, Jari; Koponen, Anne S.; Pullinen, Katri; Hägglund, Harriet; Aho, Jyrki M.; Kyröläinen, Heikki; Tikkanen, Heikki

doi:10.1016/j.resp.2012.04.002

Cited by 30 publications

(33 citation statements)

References 72 publications

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“…At peak exercise, deoxygenation was greatest in the arm muscle in comparison with the leg muscle and cerebral tissue. These findings are consistent with previous findings made during incremental cycling (Ogata et al, 2007; Peltonen et al, 2012). …”

Section: Discussionsupporting

confidence: 94%

“…In addition, a NIP reflecting acceleration of arm deoxygenation was observed in 10 subjects during the last two minutes of exercise, and an accelerated rise of

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occurred in nine of those 10 subjects approximately 1 min before the deoxygenation acceleration. Ogata et al (2007) and Peltonen et al (2012) have similarly reported that the magnitude of decrease in O 2 delivery to less active muscle is coupled to the magnitude of increase in the amount of hyperventilation during incremental cycling. Ogata et al (2007) suggested that the association would result from metabolite accumulation and the concomitant metabolic acidosis, which concurrently affect both hyperventilation and O 2 delivery to inactive muscle.…”

Section: Discussionmentioning

confidence: 99%

“…Arm muscle oxygenation has not been studied during incremental treadmill exercise, but during incremental cycling, an initial moderate decrease in oxygenation followed by a rapid decrease during more severe exercise has been reported (Ogata et al, 2007; Peltonen et al, 2012). Cerebral tissue oxygenation has a quadratic response to incremental exercise; it increases from low-to-hard intensities, followed by a plateau or decline toward baseline during severe exercise (Nielsen et al, 1999; Rooks et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Concerning incremental treadmill exercise, NIRS trends have not been compared with alterations in alveolar gas exchange. However, an exaggerated decline in active muscle oxygenation coinciding with anaerobic threshold (AT) (e.g., Bhambhani et al, 1997), an exaggerated decline in less active muscle oxygenation coupling with increase in the amount of hyperventilation (Ogata et al, 2007; Peltonen et al, 2012), and a decrease in cerebral oxygenation following respiratory compensation point (RC) (e.g., Bhambhani et al, 2007), have been demonstrated during incremental cycling.…”

Section: Introductionmentioning

confidence: 99%

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Alveolar gas exchange and tissue oxygenation during incremental treadmill exercise, and their associations with blood O2 carrying capacity

Rissanen¹,

Tikkanen²,

Koponen³

et al. 2012

Front. Physio.

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The magnitude and timing of oxygenation responses in highly active leg muscle, less active arm muscle, and cerebral tissue, have not been studied with simultaneous alveolar gas exchange measurement during incremental treadmill exercise. Nor is it known, if blood O 2 carrying capacity affects the tissue-specific oxygenation responses. Thus, we investigated alveolar gas exchange and tissue (m. vastus lateralis, m. biceps brachii, cerebral cortex) oxygenation during incremental treadmill exercise until volitional fatigue, and their associations with blood O 2 carrying capacity in 22 healthy men. Alveolar gas exchange was measured, and near-infrared spectroscopy (NIRS) was used to monitor relative concentration changes in oxy-( [O 2 Hb]), deoxy-( [HHb]) and total hemoglobin ( [tHb]), and tissue saturation index (TSI). NIRS inflection points (NIP), reflecting changes in tissue-specific oxygenation, were determined and their coincidence with ventilatory thresholds [anaerobic threshold (AT), respiratory compensation point (RC); V-slope method] was examined. Blood O 2 carrying capacity [total hemoglobin mass (tHb-mass)] was determined with the CO-rebreathing method. In all tissues, NIPs coincided with AT, whereas RC was followed by NIPs. High tHb-mass associated with leg muscle deoxygenation at peak exercise (e.g., [HHb] from baseline walking to peak exercise vs. tHb-mass: r = 0.64, p < 0.01), but not with arm muscle-or cerebral deoxygenation. In conclusion, regional tissue oxygenation was characterized by inflection points, and tissue oxygenation in relation to alveolar gas exchange during incremental treadmill exercise resembled previous findings made during incremental cycling. It was also found out, that O 2 delivery to less active m. biceps brachii may be limited by an accelerated increase in ventilation at high running intensities. In addition, high capacity for blood O 2 carrying was associated with a high level of m. vastus lateralis deoxygenation at peak exercise.

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Section: Discussionsupporting

confidence: 94%

“…In addition, a NIP reflecting acceleration of arm deoxygenation was observed in 10 subjects during the last two minutes of exercise, and an accelerated rise of

{\overset{V}{true}}_{E}

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alveolar gas exchange and tissue oxygenation during incremental treadmill exercise, and their associations with blood O2 carrying capacity

Rissanen¹,

Tikkanen²,

Koponen³

et al. 2012

Front. Physio.

Self Cite

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“…Muscle optodes were placed over the middle of the muscle belly, fixed using adhesive tape and wrapped with low compression black elastic bandage (to prevent movement and extraneous light). For PFC monitoring, the optode was placed 1–2 cm over the left PFC above the eyebrow as used in previous studies [41, 42], fixed using adhesive tape and covered with a black headband. Differential pathway factor (DPF) depends on the optical characteristics of tissue [43] and depending on age, the path length of the photons is 4–6.5 times longer than the spacing between the optodes.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Short and Long Term Endurance Training on Systemic, and Muscle and Prefrontal Cortex Tissue Oxygen Utilisation in 40 – 60 Year Old Women

et al. 2016

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PurposeAerobic endurance training (ET) increases systemic and peripheral oxygen utilisation over time, the adaptation pattern not being linear. However, the timing and mechanisms of changes in oxygen utilisation, associated with training beyond one year are not known. This study tested the hypothesis that in women aged 40–60 years performing the same current training load; systemic O2 utilisation (VO2) and tissue deoxyhaemoglobin (HHb) in the Vastus Lateralis (VL) and Gastrocnemius (GAST) would be higher in long term trained (LTT; > 5 yr) compared to a short term trained (STT; 6–24 months) participants during ramp incremental (RI) cycling, but similar during square-wave constant load (SWCL) cycling performed at the same relative intensity (below ventilatory turn point [VTP]); and that pre-frontal cortex (PFC) HHb would be similar between participant groups in both exercise conditions.MethodsThirteen STT and 13 LTT participants performed RI and SWCL conditions on separate days. VO2, and VL, GAST, and PFC HHb were measured simultaneously.ResultsVO2peak was higher in LTT compared to STT, and VO2 was higher in LTT at each relative intensities of 25%, 80% and 90% of VTP in SWCL. HHb in the VL was significantly higher in LTT compared to STT at peak exercise (4.54 ± 3.82 vs 1.55 ± 2.33 μM), and at 25% (0.99 ± 1.43 vs 0.04 ± 0.96 μM), 80% (3.19 ± 2.93 vs 1.14 ± 1.82 μM) and 90% (4.62 ± 3.12 vs 2.07 ± 2.49 μM) of VTP in SWCL.ConclusionsThe additional (12.9 ± 9.3) years of ET in LTT, resulted in higher VO2, and HHb in the VL at peak exercise, and sub—VTP exercise. These results indicate that in women 40–60 years old, systemic and muscle O2 utilisation continues to improve with ET beyond two years.

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The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes

Taylor,

Smith,

Scragg

et al. 2024

Diabetologia

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Aims/hypothesis Our aim was to characterise the in-depth metabolic response to aerobic exercise and the impact of residual pancreatic beta cell function in type 1 diabetes. We also aimed to use the metabolome to distinguish individuals with type 1 diabetes with reduced maximal aerobic capacity in exercise defined by $$\dot{V}{\text{O}}_{\text{2peak}}$$ V ˙ O 2peak . Methods Thirty participants with type 1 diabetes (≥3 years duration) and 30 control participants were recruited. Groups did not differ in age or sex. After quantification of peak stimulated C-peptide, participants were categorised into those with undetectable (<3 pmol/l), low (3–200 pmol/l) or high (>200 pmol/l) residual beta cell function. Maximal aerobic capacity was assessed by $$\dot{V}{\text{O}}_{\text{2peak}}$$ V ˙ O 2peak test and did not differ between control and type 1 diabetes groups. All participants completed 45 min of incline treadmill walking (60% $$\dot{V}{\text{O}}_{\text{2peak}}$$ V ˙ O 2peak ) with venous blood taken prior to exercise, immediately post exercise and after 60 min recovery. Serum was analysed using targeted metabolomics. Metabolomic data were analysed by multivariate statistics to define the metabolic phenotype of exercise in type 1 diabetes. Receiver operating characteristic (ROC) curves were used to identify circulating metabolomic markers of maximal aerobic capacity ($$\dot{V}{\text{O}}_{\text{2peak}}$$ V ˙ O 2peak ) during exercise in health and type 1 diabetes. Results Maximal aerobic capacity ($$\dot{V}{\text{O}}_{\text{2peak}}$$ V ˙ O 2peak ) inversely correlated with HbA1c in the type 1 diabetes group (r2=0.17, p=0.024). Higher resting serum tricarboxylic acid cycle metabolites malic acid (fold change 1.4, p=0.001) and lactate (fold change 1.22, p=1.23×10−5) differentiated people with type 1 diabetes. Higher serum acylcarnitines (AC) (AC C14:1, F value=12.25, p=0.001345; AC C12, F value=11.055, p=0.0018) were unique to the metabolic response to exercise in people with type 1 diabetes. C-peptide status differentially affected metabolic responses in serum ACs during exercise (AC C18:1, leverage 0.066; squared prediction error 3.07). The malic acid/pyruvate ratio in rested serum was diagnostic for maximal aerobic capacity ($$\dot{V}{\text{O}}_{\text{2peak}}$$ V ˙ O 2peak ) in people with type 1 diabetes (ROC curve AUC 0.867 [95% CI 0.716, 0.956]). Conclusions/interpretation The serum metabolome distinguishes high and low maximal aerobic capacity and has diagnostic potential for facilitating personalised medicine approaches to manage aerobic exercise and fitness in type 1 diabetes. Graphical Abstract

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Alveolar gas exchange and tissue deoxygenation during exercise in type 1 diabetes patients and healthy controls

Cited by 30 publications

References 72 publications

Alveolar gas exchange and tissue oxygenation during incremental treadmill exercise, and their associations with blood O2 carrying capacity

Alveolar gas exchange and tissue oxygenation during incremental treadmill exercise, and their associations with blood O2 carrying capacity

The Effect of Short and Long Term Endurance Training on Systemic, and Muscle and Prefrontal Cortex Tissue Oxygen Utilisation in 40 – 60 Year Old Women

The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes

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