Alveolar haemorrhage as a presenting feature of myeloma

Russi, EW; Odermatt, Bernhard; Joller-Jemelka, HI; Ma, Spycher

doi:10.1183/09031936.93.06020267

Cited by 11 publications

(2 citation statements)

References 8 publications

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“…In our case, there was no evidence of infection in the BAL fluid, which can trigger DAH in MM [ 7 ]. Pulmonary hemorrhage without renal failure has been reported as a presenting symptom for MM in only two cases [ 8 , 9 ]; however, in our patient, the coagulation profile was normal.…”

Section: Discussioncontrasting

confidence: 61%

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Lenalidomide-Induced Diffuse Alveolar Hemorrhage in Patient With Multiple Myeloma

Qanash¹,

Alamoudi²,

Alsuraihi³

et al. 2023

Cureus

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We present a case of multiple myeloma that was treated with a regimen that included lenalidomide. Lenalidomide, a thalidomide analog, is an immunomodulatory drug created synthetically by changing the chemical makeup of thalidomide to increase efficacy and lessen negative effects. It has been authorized for the treatment of relapsed or resistant multiple myeloma. In the case discussed in this report, the patient's lenalidomide dosage was changed to account for her renal impairment. Regardless of this adjustment of the dose, the patient presented with lung infiltrates, hemoptysis, and fever. Unfortunately, she was diagnosed with diffuse alveolar hemorrhage (DAH) secondary to lenalidomide after excluding other causes of hemoptysis. To the best of our knowledge, we believe this is the first case of DAH reported with lenalidomide in Saudi Arabia, which also discusses the possible therapeutic options for such presentations.

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Section: Discussioncontrasting

confidence: 61%

“…White blood cells 6x10 9 The patient was diagnosed with lenalidomide-induced pulmonary hemorrhage after ruling out other causes. She was started on 100 mg hydrocortisone every six hours for five days.…”

Section: Laboratory Results Patient Results Normal Range/valuementioning

confidence: 99%