Alveolar ridge augmentation in rats by Bio‐Oss

Pinholt, Else Marie; Bang, Gisle; Haanæs, Hans R.

doi:10.1111/j.1600-0722.1991.tb01878.x

Cited by 55 publications

(71 citation statements)

References 25 publications

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“…In this study, the presence of macrophages and giant cells around the particles, as observed previously (2,10), may explain the reduction of the amount of particles throughout the experimental time. On the other hand, a previous report suggested that this type of material may also be incorporated into the newly formed bone (4,5).…”

Section: Discussionsupporting

confidence: 83%

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Effect of low level laser therapy on the repair of bone defects grafted with inorganic bovine bone

et al. 2003

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The aim of this study was to assess histologically the effect of LLLT (λ 830 nm) on the repair of standardized bone defects on the femur of Wistar albinus rats which were grafted with inorganic bovine bone Gen-ox ® . Three randomized groups were studied: group I (control, n=6); group II (Gen-ox ® , n=9) and group III (Gen-ox ® + LLLT, n=9). The animals were irradiated every 48 h during 15 days; the first irradiation was performed immediately after the procedure. The animals were irradiated transcutaneuosly at four points around the defect. At each point a dose of 4 J/cm 2 was given (Ø~0.6 mm, 40 mW) and the total dose per session was 16 J/cm 2 . The animals were killed by an overdose of general anesthetic 15, 21 and 30 days after surgery. The specimens were routinely processed by embedding in paraffin, serially cut and stained with H&E and Picrosirius and analyzed under light microscopy. The results showed evidence of a more advanced repair in the irradiated group when compared to the non-irradiated groups. The repair of the irradiated group was characterized by both increased bone formation and amount of collagen fibers around the graft within the cavity from the 15th day after surgery, also considering the osteoconductive capacity of the Gen-ox ® . We conclude that LLLT had a positive effect on the repair of bone defects implanted with inorganic bovine bone.

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Section: Discussionsupporting

confidence: 83%

“…This material was used previously for the reconstruction of alveolar ridge (2), bone loss associated to both periodontal and periapical lesions (3), on bone defects (4) and as a hemostatic agent (1).…”

Section: Introductionmentioning

confidence: 99%

Effect of low level laser therapy on the repair of bone defects grafted with inorganic bovine bone

et al. 2003

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“…However, regarding the resorption of Bio-Oss, contradicting reports have emerged. On one hand, a previous study revealed that the bovine bone mineral underwent resorption 21) . On the other hand, numerous researchers claimed that the resorption process of BioOss ® was very slow [22][23][24] .…”

Section: Discussionmentioning

confidence: 99%

The bone-healing effect of a xenograft in a rat calvarial defect model

2009

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Bone grafts have been widely used to fill osseous defects in medicine, dentistry, and periodontology. The purpose of this study was to investigate the effects of a xenograft (Unilab Surgibone ® ) on experimentally created parietal bone defects in rats. To this end, 14 rats were employed in the present study and in each of them, 5-mm-diameter defects were created on the parietal bone. The right defect sites were filled with the xenograft material, while the left sites were used as control. After 30 days, the rats were sacrificed and tissue samples were retrieved from the defect sites of the cranium. Dense collagenous tissue was observed in the control area, whereas the xenograft particles were surrounded by a fibrous tissue layer at the implantation site. Based on the findings obtained, it could be concluded that the investigated xenograft seemed biocompatible and could be proposed as a potential material for filling osseous defects.

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“…It may be used alone or mixed with cancellous autogenous bone for the reconstruction of limited horizontal alveolar ridge defects, for subantral bone augmentation as part of sinus lift procedures, for periodontal regeneration, and for the healing of extraction sockets. [22][23][24][25] Although only one study has reported on the development of FB of the maxillary sinus following sinus bone grafting, in recent years, we have observed a resurgence of cases presenting with such a calamitous association. 26 Thus, the present case-control study was undertaken to assess the possible association between sinus bone graft material and subsequent development of FB of the maxillary sinus.…”

mentioning

confidence: 99%

Association between maxillary sinus fungus ball and sinus bone grafting with deproteinized bovine bone substitutes: a case-control study

Scolozzi

Perez

Verdeja

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective. To evaluate the association between sinus bone graft and the development of fungus ball (FB) of the maxillary sinus. Study Design. The charts of all patients seen for surgical treatment of maxillary sinus FB following sinus bone grafting between 2006 and 2014 were reviewed. The charts of 49 participants were selected from our internal registry for comparison as controls. The association between FB and age, gender, smoking habits, associated co-morbidities, and bone grafting material was evaluated. FB of the maxillary sinus was estimated by using an odds ratio with a Yates' correction. P values were computed using Fisher's exact test, and the statistical significance was set at a P value < .05. Results. All 13 cases (100%) with FB of the maxillary sinus had received anorganic bovine bone as the bone substitute (P ¼ .0001). There were significantly more women in the case group than in the control group (84.6% in the cases vs 40.8% in the controls; P ¼ .01).Conclusions. This study demonstrated a significant association between a specific deproteinized bovine bone substitute use as sinus bone graft material and subsequent development of FB of the maxillary sinus. (Oral Surg Oral Med Oral Pathol Oral Radiol 2016;121:e143-e147) Fungus ball (FB) represents the most common form of noninvasive extramucosal fungal infection involving the paranasal sinuses and is encountered in almost 28.5% of patients suffering from chronic maxillary sinusitis. 1-3 Aspergillus fumigatus is, by far, the most frequent causative agent found in Europe, and the root canal overfilling with the passage of zinc oxide endodontic sealers into the maxillary sinus is the most commonly recognized risk factor for the development of FB in up to 84% of patients. [1][2][3][4][5][6] Although this form of sinusitis typically affects healthy adults and has a striking female predominance, several pathologic conditions, such as diabetes, immunodeficiency diseases, and immunosuppressive and chronic corticosteroid and antibiotic treatments have been pointed out as potential predisposing factors favoring the colonization and subsequent overgrowth of the fungal hyphae. [1][2][3] Since its first report in 1980 by Boyne and James, grafting of the maxillary sinus floor has rapidly become the most common surgical procedure used to increase the subantral alveolar bone height of the posterior maxilla for subsequent dental implant placement. 7 Although reported as a predictable and reliable procedure, sinus bone graft has, nevertheless, been associated with several intra-and postoperative complications, such as sinus membrane perforation, maxillary sinusitis, wound dehiscence with graft exposure, and graft infection. In most cases, complications resolve with no need for further surgery and with no substantial impact on implant survival; however, in some cases, complications may lead to complete loss of the graft material, thus compromising the subsequent implant-supported dental restoration. [8][9][10][11][12][13][14][15][16][17] Although the literature co...

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Alveolar ridge augmentation in rats by Bio‐Oss

Cited by 55 publications

References 25 publications

Effect of low level laser therapy on the repair of bone defects grafted with inorganic bovine bone

Effect of low level laser therapy on the repair of bone defects grafted with inorganic bovine bone

The bone-healing effect of a xenograft in a rat calvarial defect model

Association between maxillary sinus fungus ball and sinus bone grafting with deproteinized bovine bone substitutes: a case-control study

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