Alveolar space filling ratio as a favorable prognostic factor in small peripheral squamous cell carcinoma of the lung

Watanabe, Yukihiro; Yokose, Tomoyuki; Sakuma, Yoshiki; Hasegawa, Chikako; Saito, Haruhiro; Yamada, Kozo; Ito, Hiroyuki; Tsuboi, Masahiro; Nakayama, Haruhiko; Konishi, Yoichi

doi:10.1016/j.lungcan.2010.12.001

Cited by 22 publications

(15 citation statements)

References 17 publications

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“…The presence of tumor cells within airspaces beyond the edge of the main tumor differs from the previously reported predominant alveolar space filling pattern identified within the main tumor that has been reported to be associated with favorable prognosis. 26, 27 However, this pattern has not been recognized in other recent studies. 3, 4 The distinction from alveolar macrophages is less of a challenge than in adenocarcinoma since in SCC the alveolar tumor cells consist of solid nests.…”

Section: Discussionmentioning

confidence: 75%

Spread through Air Spaces (STAS) Is an Independent Predictor of Recurrence and Lung Cancer–Specific Death in Squamous Cell Carcinoma

Tan

Kadota

et al. 2017

Journal of Thoracic Oncology

152

154

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Introduction Spread through air spaces (STAS) is a recently recognized pattern of invasion in lung adenocarcinoma, however, it has not yet been characterized in squamous cell carcinoma (SCC). Methods We reviewed 445 resected stage I-III lung SCC and investigated the clinical significance of STAS. Cumulative incidence of recurrence (CIR) and lung cancer-specific death (CID) were evaluated by competing risks analyses and overall survival (OS) by Cox models. Results Of total 445 patients, 336 (76%) were >65 years old. Among 273 patients who died, 91 (33%) died of lung cancer whereas the remaining died of competing events or unknown cause. STAS was observed in 132 patients (30%) and the frequency increased with stage. The cumulative incidence of any, distant, and locoregional recurrence as well as lung cancer-specific death were significantly higher in patients with STAS compared to those without STAS, whereas there was no statistically significant difference in OS. In multivariable models for any recurrence and lung cancer-specific death, STAS was an independent predictor for both outcomes (p=0.034 and 0.016, respectively). Conclusion STAS was present in one third of resected lung SCC. In competing risks analysis in a cohort where three fourths of the patients were elderly, STAS was associated with lung cancer-specific outcomes. Our findings suggest that STAS is one of the most prognostically significant histologic findings in lung SCC.

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Section: Discussionmentioning

confidence: 75%

Spread through Air Spaces (STAS) Is an Independent Predictor of Recurrence and Lung Cancer–Specific Death in Squamous Cell Carcinoma

Tan

Kadota

et al. 2017

Journal of Thoracic Oncology

152

154

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“…In the peripheral area of primary lung SqCC, the tumor cell infiltrate fills and destroys the alveolar spaces, associated with a weak desmoplastic reaction (Funai et al 2003;Watanabe et al 2011). On the other hand, in the central area, the tumor cells form irregular-shaped nests associated with marked desmoplastic reaction.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung

Udagawa

Ishii

Morise

et al. 2015

J Cancer Res Clin Oncol

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“…58,60,61 These include recognition of an alveolar space-filling variant, which corresponds to a favorable prognosis. 58,61 However, this pattern is seen in the minority of cases, more often it is seen only focally and, in a study from North America, prognostic significance could not be demonstrated.…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

Pathology

Wallace¹,

Travis²

2016

Murray and Nadel's Textbook of Respiratory Medicine

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Alveolar space filling ratio as a favorable prognostic factor in small peripheral squamous cell carcinoma of the lung

Cited by 22 publications

References 17 publications

Spread through Air Spaces (STAS) Is an Independent Predictor of Recurrence and Lung Cancer–Specific Death in Squamous Cell Carcinoma

Spread through Air Spaces (STAS) Is an Independent Predictor of Recurrence and Lung Cancer–Specific Death in Squamous Cell Carcinoma

Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung

Pathology

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