“…Overall, the mortality rate remains elevated despite advances in neonatal resuscitation and intensive care [2,3]. Mortality is attributed mainly to a lethal combination of lung hypoplasia [4,5], pulmonary hypertension [6,7], and right-to-left shunting [8][9][10].Endothelins (ETs) consist of a family of three 21 amino acid peptides (ET-1, ET-2, and ET-3) with potent vasoactive, bronchoactive, and promitogenic activities [11][12][13][14]. Each of 0022-3468/$ -see front matter D…”