Alveolar Type I Epithelial Cells: The Forgotten Cells in Fetal Lung Development and Lung Injury

Abstract

CitationNajrana T, Sanchez-Esteban J. Alveolar Type I epithelial cells: The forgotten cells in fetal lung development and lung injury. Pulm Res Respir Med Open J. 2016; 2(4): e6-e9.

Oligohydramnios compromises lung cells size and interferes with epithelial–endothelial development

“…Type I cells cover a large surface area in the developed lung, and are important in many of the lung functions such as gas exchange, fluid balance in the alveolus, and innate immunity . Studies from T1α knockout mice indicate that alveolar type I cells may be also critical for normal lung development since T1α knockout mice died at birth of respiratory failure and histologic analysis show underdeveloped lungs …”