Alzheimer Dementia and Microvascular Pathology: Blood-Brain Barrier Permeability Imaging

문, 원진

doi:10.3348/jksr.2020.81.3.488

Cited by 3 publications

(3 citation statements)

References 66 publications

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“…Although the pathogenesis of many neurodegenerative and cerebrovascular diseases remains unclear, blood-brain barrier (BBB) breakdown and leakage have been implicated in their mechanism [ 1 2 3 ]; the relationship between BBB permeability and neurodegenerative diseases has thus garnered increasing attention [ 4 ]. Studies have reported that BBB breakdown is associated with rapid cognitive decline [ 5 ] and contributes to cognitive impairment independent of Alzheimer's disease biomarkers [ 6 7 ].…”

Section: Introductionmentioning

confidence: 99%

Regional Differences in Blood-Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic Contrast-Enhanced MRI-Based Study

Lim

Kim

et al. 2021

Korean J Radiol

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Objective This study aimed to determine whether there are regional differences in the blood-brain barrier (BBB) permeability of cognitively normal elderly participants and to identify factors influencing BBB permeability with a clinically feasible, 10-minute dynamic contrast-enhanced (DCE) MRI protocol. Materials and Methods This IRB-approved prospective study recruited 35 cognitively normal adults (26 women; mean age, 64.5 ± 5.6 years) who underwent DCE T1-weighted imaging. Permeability maps (K trans ) were coregistered with masks to calculate the mean regional values. The paired t test and Friedman test were used to compare Ktrans between different regions. The relationships between K trans and the factors of age, sex, education, cognition score, vascular risk burden, vascular factors on imaging, and medial temporal lobar atrophy were assessed using Pearson correlation and the Spearman rank test. Results The mean permeability rates of the right and left hippocampi, as assessed with automatic segmentation, were 0.529 ± 0.472 and 0.585 ± 0.515 (K trans , × 10 −3 min −1 ), respectively. Concerning the deep gray matter, the K trans of the thalamus was significantly greater than those of the putamen and hippocampus ( p = 0.007, p = 0.041). Regarding the white matter, the K trans value of the occipital white matter was significantly greater than those of the frontal, cingulate, and temporal white matter ( p < 0.0001, p = 0.0007, p = 0.0002). The variations in K trans across brain regions were not related to age, cognitive score, vascular risk burden, vascular risk factors on imaging, or medial temporal lobar atrophy in the study group. Conclusion Our study demonstrated regional differences in BBB permeability (K trans ) in cognitively normal elderly adults using a clinically acceptable 10-minutes DCE imaging protocol. The regional differences suggest that the integrity of the BBB varies across the brains of cognitively normal elderly adults. We recommend considering regional differences in K trans values when evaluating BBB permeability in patients with neurodegenerative diseases.

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Section: Introductionmentioning

confidence: 99%

Regional Differences in Blood-Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic Contrast-Enhanced MRI-Based Study

Lim

Kim

et al. 2021

Korean J Radiol

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“…Imaging findings of microvascular pathology, also known as a SVD in AD, include lacunes, WMH, cerebral microbleed, and enlarged perivascular spaces (ePVSs). 11 Among them, WMH is the most widely investigated and validated for SVD marker until now. WMH is also an imaging factor that is correlated with cognitive aging and AD.…”

Section: Neuroimaging Test: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

“…This distribution is determined based on several physiological indicators, such as arterial input function, which is one of the least affected indicators by imaging conditions or imaging techniques. 11 …”

Section: Neuroimaging Test: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Diagnostic Tools for Alzheimer’s Disease: A Narrative Review Based on Our Own Research Experience

Park

Kwon

Kim

et al. 2023

Dement Neurocogn Disord

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Alzheimer’s disease (AD), one of the most representative neurodegenerative diseases, has diverse neurobiological and pathophysiological mechanisms. Treatment strategies targeting a single mechanism have repeated faced failures because the mechanism of neuronal cell death is very complex that is not fully understood yet. Since complex mechanisms exist to explain AD, a variety of diagnostic biomarkers for diagnosing AD are required. Moreover, standardized evaluations for comprehensive diagnosis using neuropsychological, imaging, and laboratory tools are needed. In this review, we summarize the latest clinical, neuropsychological, imaging, and laboratory evaluations to diagnose patients with AD based on our own experience in conducting a prospective study.

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MoS2 quantum dots based on lipid drug delivery system for combined therapy against Alzheimer's disease

Xie

2023

Journal of Drug Delivery Science and Technology

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Alzheimer Dementia and Microvascular Pathology: Blood-Brain Barrier Permeability Imaging

Cited by 3 publications

References 66 publications

Regional Differences in Blood-Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic Contrast-Enhanced MRI-Based Study

Regional Differences in Blood-Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic Contrast-Enhanced MRI-Based Study

Diagnostic Tools for Alzheimer’s Disease: A Narrative Review Based on Our Own Research Experience

MoS2 quantum dots based on lipid drug delivery system for combined therapy against Alzheimer's disease

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