Alzheimer Disease-Type 3 Diabetes: Traditional Review

TEKİN, Bilge; ELMACIOĞLU, Funda; ÜLKER, Mutlu Tuçe

doi:10.5336/healthsci.2022-94043

Cited by 1 publication

(1 citation statement)

References 58 publications

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“…In addition, various studies have shown that a history of depression increases the risk of dementia, and there is a positive relationship between the severity of depression and the likelihood of developing dementia 33 , 34 . Indeed, a depression diagnosis is known to be associated with receiving a dementia diagnosis within a span of up to 20 years 35 . Individuals diagnosed with depression have been observed to experience shrinkage in the hippocampus region of the brain, which serves as a significant reference in explaining the relationship between depression and Alzheimer's 36 , 37 .…”

Section: Introductionmentioning

confidence: 99%

Insights from Turkey's big data: unraveling the preventability, pathogenesis, and risk management of Alzheimer's disease (AD)

Yiğit,

Ata,

Dinçer

et al. 2024

Sci Rep

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Extensive research into dementia has more recently honed in on several key areas. These areas include the advancement of techniques such as the accumulation of amyloid-β and tau proteins, the monitoring of cerebral hypometabolism rates etc. The primary objective of this study is to explore the intricate interplay between Alzheimer's disease (AD)—other dementias (D) and various chronic illnesses in terms of time, intensity, and connectivity. In this context, we retrospectively examined data of 149,786 individuals aged 65 and above who received diagnoses of AD and D in the year 2020. At first, logistic regression (LR) analysis has been made with “sex”, “age” and “foreigner” (citizenship status) independent variables for AD and D. The LR models shows that while “sex” and “age” variables have a small rate on the risk of developing AD/D, it is detected that being a foreigner increase the risk of AD and D as 69.8% and 88.5% respectively. Besides, the LR models have middle-level success prediction rate for both of the two dependent variables. Additionally, we used the parallel coordinates graphs method within the R Studio to visualize their relationships and connections. The findings of this investigation strongly suggest that AD/D don’t stand as isolated conditions, but rather stem from intricate interactions and progressive processes involving diverse chronic diseases over time. Notably, ailments including hypertension, coronary artery disease, diabetes, hyperlipidemia, and psychological disorders, contribute substantially to the emergence of both AD and D. This study highlights that the fight against AD/D can only be possible with next-generation prophylactic interventions that can predict and manage risks. Such an approach holds the potential to potentially lower AD and dementia to levels that are amenable to treatment.

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