Alzheimer, Parkinson, dementia, and phytochemicals: insight review

Can, Basak; Sanlier, Nevin

doi:10.1080/10408398.2023.2299340

Cited by 4 publications

(2 citation statements)

References 232 publications

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“…Dementia is one of the most feared neurological disorders, and the number of people with dementia is rapidly increasing. Alzheimer's disease, a neurodegenerative condition defined by the high accumulation of neurofibrillary tangles and amyloid plaques in the brain, and Parkinson's disease, characterized mainly by tremor, rigidity, bradykinesia, and postural instability, are conditions that the elderly face over time [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…To maintain or improve brain health or slow and reverse dementia, nearly a quarter of adults currently use some dietary supplement, including vitamins, minerals, and amino acids [17,[21][22][23]. Novel therapeutic opportunities for neurodegenerative diseases include strategies for enhancing cognitive function and reducing amyloid deposition, presenting new avenues for the treatment of these conditions [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

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Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Valotto Neto,

Reverete de Araujo,

Moretti Junior

et al. 2024

Antioxidants

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The aging of the global population has increased the prevalence of neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic acid, and quercetin, demonstrates the potential for brain health. Limited research has been conducted on the therapeutic applications of BM in neurodegenerative conditions. This systematic review aims to project BM’s beneficial role in brain disorders. BM has anti-apoptotic and antioxidant actions and can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, and increase neuroprotection. The included twenty-two clinical trials demonstrated that BM can reduce Nuclear Factor-κB phosphorylation, improve emotional function, cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, and psychiatric problems. Moreover, BM can reduce the levels of pro-inflammatory biomarkers and oxidative stress. Here, we highlight that BM provides notable therapeutic benefits and can serve as a complementary approach for the care of patients with neurodegenerative conditions associated with brain disorders. This review adds to the growing interest in natural products and their potential therapeutic applications by improving our understanding of the mechanisms underlying cognitive function and neurodegeneration and informing the development of new therapeutic strategies for neurodegenerative diseases.

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