Alzheimer's Disease: A Cerebral AmyloidosisA Cooperative Study to Correlate Clinical, Biochemical and Pathologic-anatomical Findings

Böhl, Jürgen; Störkel, S; Schulze, Eva; Tschank, Georg; Haas, St.; Krausbeck, E.; Gather, W.; Katzman, K.; Brocks, Dietrich G.

doi:10.1055/s-2007-1017192

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are indications that disturbances of the BCB commonly occur in DAT [2,38,40]. Indirect evidence for BCB abnormalities exists in the finding of a severe degree of cerebral amyloid anglo-Offprint requests to: L. Fr61ich, Psychiatrische Klinik und Poliklinik, Universitfits-Nervenklinik, Ftichsleinstrasse 15, W-8700 Wfirzburg, Federal Republic of Germany pathy or cerebrovascular amyloidosis (CAA) around brain vessels of patients with DAT [4,25]. Widespread amyloid deposition may also be detected in the cerebral and cerebellar cortex [26].…”

Section: Introductionmentioning

confidence: 99%

Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF/serum ratios of albumin and IgG

Frölich

Kornhuber

Ihl

et al. 1991

Eur Arch Psychiatry Clin Nuerosci

View full text Add to dashboard Cite

Serum and cerebrospinal fluid (CSF) from 25 patients with dementia of Alzheimer type (DAT) and 25 controls were assayed for concentrations of albumin and IgG. The severity of dementia was rated with the Mini Mental State Examination. The CSF/serum ratio for albumin and IgG as well as the IgG index were used to evaluate blood-CSF barrier function in the respective groups. The control group was matched for age, sex and the indirect alcohol parameters, mean corpuscular volume and gamma-glutamyltranspeptidase. There were no signs of dysfunction of the blood-CSF barrier for proteins or signs of local synthesis of IgG in the central nervous system (CNS) of the demented patients. The permeability of the blood-CSF barrier appeared to be unrelated to dementia severity. The data do not support the hypothesis that a pathological leakage through the blood-CSF barrier facilitates the entry of extraneuronal proteins to the CNS, which might contribute to the pathophysiological process in DAT.

show abstract

Section: Introductionmentioning

confidence: 99%

Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF/serum ratios of albumin and IgG

Frölich

Kornhuber

Ihl

et al. 1991

Eur Arch Psychiatry Clin Nuerosci

View full text Add to dashboard Cite

show abstract

“…Previous studies have demonstrated patients with Alzheimer's disease (in comparison to controls) to show alterations in blood vessel walls, including increased collagen deposition (Bohl et al, 1986). Since decorin is known to be associated with collagen, one could speculate that in AD brain an increase in collagen accumulation would also involve an increased accumulation of decorin in the walls of blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease.

Snow¹,

Mar²,

Nochlin³

et al. 1992

J Histochem Cytochem.

141

View full text Add to dashboard Cite

We used a polydonal antibody and a mixture of three monoclonal antibodies (MAb), all recognizing the protein core of the s m a l l dermatan sulfate proteoglycan (DSPG) (known as PG-II or decorin) derived from human skin fibroblasts, to immunolocalize this molecule in the characteristic lesions in Alzheimer's brain. All antibodies demonstrated positive decorin immunoStaining in both the amyloid deposits of neuritic plaques (NPs) and the filamentous structures within neurofbrillaty tangles (NFTs). Unlike heparan sulfate proteoglycans (HSPGs), which tend to be evenly distributed throughout NPs containing amyloid fibrils, decorin was pri-

show abstract

Morphological diagnosis of vascular and senile dementia (the importance of cerebral congophilic angiopathy)

Geinisman

Oksova

1989

Neurosci Behav Physiol

View full text Add to dashboard Cite

Alzheimer's Disease: A Cerebral AmyloidosisA Cooperative Study to Correlate Clinical, Biochemical and Pathologic-anatomical Findings

Cited by 4 publications

References 0 publications

Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF/serum ratios of albumin and IgG

Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF/serum ratios of albumin and IgG

Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease.

Morphological diagnosis of vascular and senile dementia (the importance of cerebral congophilic angiopathy)

Contact Info

Product

Resources

About