2009
DOI: 10.1523/jneurosci.3502-09.2009
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Alzheimer's Disease Affects Progenitor Cells through Aberrant β-Catenin Signaling

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Cited by 4 publications
(2 citation statements)
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“…22,23 For example, AD patients show increased senescence and reduced paracrine angiogenic activity of PC, and the addition of high concentration A-β-amyloid to a PC culture reduces PC counts and endothelial nitric oxide synthase and induced apoptosis. 24 In 29 individuals with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), PC were decreased compared to 29 matched controls, and the count correlated with performance on cognitive and motor tests.…”
Section: Discussionmentioning
confidence: 99%
“…22,23 For example, AD patients show increased senescence and reduced paracrine angiogenic activity of PC, and the addition of high concentration A-β-amyloid to a PC culture reduces PC counts and endothelial nitric oxide synthase and induced apoptosis. 24 In 29 individuals with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), PC were decreased compared to 29 matched controls, and the count correlated with performance on cognitive and motor tests.…”
Section: Discussionmentioning
confidence: 99%
“… 24 In the case of Alzhiemer’s and Parkinson’s diseases, transcription factor Ngn2 expressions was significantly decreased. 25 The GFAP constitute intermediate filaments as a part of cytoskeleton in astrocytes. Reactive gliosis is a response of astrocytes to a variety of brain insults that are characterized by hypertrophy of the cell bodies and processes, altered gene expression, increased expression of GFAP in some neurodegenerative diseases.…”
Section: Introductionmentioning
confidence: 99%