Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology

Calderón‐Garcidueñas, Lilian; González-Maciel, Angélica; Reynoso-Robles, Rafael; Kulesza, Randy J.; Mukherjee, Partha S.; Torres‐Jardón, Ricardo; Rönkkö, Topi; Doty, Richard L.

doi:10.1016/j.envres.2018.06.027

Cited by 85 publications

(70 citation statements)

References 101 publications

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“…They found that oxidative potential correlated with Cu/Zn content but not with biological effects, and that ventilation patterns had little effect on intrinsic PM 10 composition and toxicological potential, which suggests a significant involvement of local sources. Calderón-Garcidueñas et al [110,111] reported associations between exposure and the development of Alzheimer and Parkinson's diseases in childhood and young adults, adding to the growing evidence that long-term exposure to air pollution is a risk factor for a number of neurodegenerative diseases, neuroinflammation, and altered innate immune response. O'Neill et al [112] showed that air pollution exposure in Mexico City may be a risk factor for preterm births, probably through inflammatory mechanisms.…”

Section: Health Benefits Of Air Quality Improvementmentioning

confidence: 99%

Experience from Integrated Air Quality Management in the Mexico City Metropolitan Area and Singapore

Molina

Velasco²,

Retama³

et al. 2019

Atmosphere

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More than half of the world’s population now lives in cities as a result of unprecedented urbanization during the second half of the 20th century. The urban population is projected to increase to 68% by 2050, with most of the increase occurring in Asia and Africa. Population growth and increased energy consumption in urban areas lead to high levels of atmospheric pollutants that harm human health, cause regional haze, damage crops, contribute to climate change, and ultimately threaten the society’s sustainability. This article reviews the air quality and compares the policies implemented in the Mexico City Metropolitan Area (MCMA) and Singapore and offers insights into the complexity of managing air pollution to protect public health and the environment. While the differences in the governance, economics, and culture of the two cities greatly influence the decision-making process, both have made much progress in reducing concentrations of harmful pollutants by implementing comprehensive integrated air quality management programs. The experience and the lessons learned from the MCMA and Singapore can be valuable for other urban centers, especially in the fast-growing Asia-Pacific region confronting similar air pollution problems.

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Section: Health Benefits Of Air Quality Improvementmentioning

confidence: 99%

Experience from Integrated Air Quality Management in the Mexico City Metropolitan Area and Singapore

Molina

Velasco²,

Retama³

et al. 2019

Atmosphere

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“…The airborne toxicants may also make their way to the brain directly through the olfactory pathway, leading to neuronal damage. Of note, it was shown that high levels of air pollution could result in neurodegenerative diseases-related pathology within the olfactory bulb (Calderon-Garciduenas et al, 2018). Pollution and toxic exposure have been linked to poor health and might thus constitute a potential mediator in the relationship between OI and mortality (Fuller-Thomson and Fuller-Thomson, 2019).…”

Section: Reflection Of General Poor Healthmentioning

confidence: 99%

Mechanisms Linking Olfactory Impairment and Risk of Mortality

et al. 2020

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Olfaction is a sense involved in a complex set of tasks, influencing eating behavior, increasing awareness of environmental hazards and affecting social communication. Surprisingly, smell disorders are very frequent, especially in the elderly population. Several recent studies conducted mostly in older subjects have demonstrated a strong association between olfactory impairment and overall mortality risk, with anosmia being even more predictive of 5 years mortality risk than cardiovascular disease. Presently, the underlying pathophysiology linking olfactory impairment to mortality remains unknown and only putative mechanisms are suggested. This review aims to examine the link between olfactory impairment and mortality and to discuss existing ideas on underlying existing mechanisms including, (1) the effect of olfactory loss on nutrition, life-threatening situations and social interactions, (2) associated neurodegenerative diseases, (3) accelerated brain aging, and (4) reflection of general health status being reflected in olfactory function.

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“…Despite its removal from gasoline and most paint products, lead remains a ubiquitous environmental pollutant. Biologically plausible relationships have been suggested with other pervasive environmental exposures, such as polychlorinated biphenyls and urban air pollution, but the findings are inconsistent.…”

Section: The Past 10 Yearsmentioning

confidence: 99%

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

2019

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There is evidence from observational studies for a role of a number of environmental exposures and lifestyle habits in modulating the risk for Parkinson's disease. Environmental and lifestyle associations, if causal, represent opportunities for Parkinson's disease prevention or disease modification at individual and population levels. In the past decade, additional evidence has been published that improves causal inference and/or enhances our understanding of the complexity of these associations. A number of gene–environment interactions have been elucidated, and our understanding of the roles of physical activity, pesticide and other chemical exposures, dietary habits, emotional stress, head injury, and smoking has been refined. In the next decade, better techniques will help us to close the gaps in our knowledge, including taking into account Parkinson's disease heterogeneity and gene and risk factor interactions in observational studies. To do this, larger datasets, global consortia, genomewide environment interaction studies, prospective studies throughout the lifespan, and improvements in the methodology of clinical trials of physical activity will be key. Despite the caveats of observational studies, a number of low‐risk and potentially high‐yield recommendations for lifestyle modification could be made to minimize the individual and societal burdens of Parkinson's disease, including dietary modifications, increasing physical activity, and head injury avoidance. Furthermore, a reduction in pesticide use could have a major impact on global health related to and beyond Parkinson's disease. Given the increasing prevalence of this disorder, formulating and promoting these recommendations should be a high priority. © 2019 International Parkinson and Movement Disorder Society

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Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology

Cited by 85 publications

References 101 publications

Experience from Integrated Air Quality Management in the Mexico City Metropolitan Area and Singapore

Experience from Integrated Air Quality Management in the Mexico City Metropolitan Area and Singapore

Mechanisms Linking Olfactory Impairment and Risk of Mortality

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

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Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology

Cited by 85 publications

References 101 publications

Experience from Integrated Air Quality Management in the Mexico City Metropolitan Area and Singapore

Experience from Integrated Air Quality Management in the Mexico City Metropolitan Area and Singapore

Mechanisms Linking Olfactory Impairment and Risk of Mortality

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

Contact Info

Product

Resources

About

Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology