Alzheimer’s disease and its related dementias in US Native Americans: A major public health concern

Sehar, Ujala; Kopel, Jonathan; Reddy, P. Hemachandra

doi:10.1016/j.arr.2023.102027

Cited by 11 publications

(1 citation statement)

References 93 publications

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“…Alzheimer's disease (AD) is the most common cause of dementia in elderly people and is a significant public health issue. [83] AD patients have numerous clinical manifestations, which usually include brain inflammation, synaptic changes, neuronal death, and the accumulation of amyloid protein aggregates and neurofibrillary tangles in the brain. [84,85] Despite the development of numerous in vitro models and animals for Alzheimer's disease, still no experimental method can reproduce all of the disease's essential characteristics.…”

Section: Neurodegenerative Disorder Modelmentioning

confidence: 99%

Advances and Challenges in Cerebral Organoids Research

Luo,

Xu,

Liu

et al. 2024

Advanced NanoBiomed Research

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Cerebral organoids are three‐dimensional (3D) aggregates with a more advanced composition, maturation, and architecture. It has emerged as a novel and sophisticated model system for studying neurodevelopment and neurological disorders, in comparison to conventional two‐dimensional (2D) cell cultures. However, due to the extraordinarily complex nature of brain development, current cerebral organoids are not as functional and mature as brains. The development of cerebral organoids requires a culture system with sufficient developmental patterning factors, essential cell components, and vasculature. In this review, the critical factors and events that contribute to the development of cerebral organoids are focused on. The advanced design, fabrication techniques, and technologies are also discussed to enhance the application potential of cerebral organoid technology.

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Section: Neurodegenerative Disorder Modelmentioning

confidence: 99%