Alzheimer's disease genes and proteins associated with resistance and aerobic training: An in silico analysis

Coutinho, Luciana Aparecida; Leão, Luana Lemos; Cassilhas, Ricardo Cardoso; Paula, Alfredo Maurício Batista de; Deslandes, Andréa Camaz

doi:10.1016/j.exger.2022.111948

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…Research studies have shown that a consistent practice of physical activity is associated with a lower risk of cardiovascular disease and physically active individuals are less likely to develop dementia [ 60 , 63 , 64 ]. Research at the cellular and molecular levels coupled with in silico studies suggested that physical exercise impacts brain health by regulating and enhancing genes, proteins, and other neurotrophic factors that directly affect memory, mood, assimilation, and growth [ 65 , 66 , 67 , 68 , 69 , 70 ]. Specifically for brain health, three types of exercise are recommended: Aerobic exercise increases heart rate and oxygen uptake, thereby improving cardiovascular health, which in turn benefits the brain.…”

Section: Multiple Strategies To Optimize Brain Healthmentioning

confidence: 99%

Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer’s Disease and MCI: A Review

Rao¹,

Subramaniam

Gregory³

et al. 2023

IJMS

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Alzheimer’s disease (AD) is a multifactorial, progressive, neurodegenerative disease typically characterized by memory loss, personality changes, and a decline in overall cognitive function. Usually manifesting in individuals over the age of 60, this is the most prevalent type of dementia and remains the fifth leading cause of death among Americans aged 65 and older. While the development of effective treatment and prevention for AD is a major healthcare goal, unfortunately, therapeutic approaches to date have yet to find a treatment plan that produces long-term cognitive improvement. Drugs that may be able to slow down the progression rate of AD are being introduced to the market; however, there has been no previous solution for preventing or reversing the disease-associated cognitive decline. Recent studies have identified several factors that contribute to the progression and severity of the disease: diet, lifestyle, stress, sleep, nutrient deficiencies, mental health, socialization, and toxins. Thus, increasing evidence supports dietary and other lifestyle changes as potentially effective ways to prevent, slow, or reverse AD progression. Studies also have demonstrated that a personalized, multi-therapeutic approach is needed to improve metabolic abnormalities and AD-associated cognitive decline. These studies suggest the effects of abnormalities, such as insulin resistance, chronic inflammation, hypovitaminosis D, hormonal deficiencies, and hyperhomocysteinemia, in the AD process. Therefore a personalized, multi-therapeutic program based on an individual’s genetics and biochemistry may be preferable over a single-drug/mono-therapeutic approach. This article reviews these multi-therapeutic strategies that identify and attenuate all the risk factors specific to each affected individual. This article systematically reviews studies that have incorporated multiple strategies that target numerous factors simultaneously to reverse or treat cognitive decline. We included high-quality clinical trials and observational studies that focused on the cognitive effects of programs comprising lifestyle, physical, and mental activity, as well as nutritional aspects. Articles from PubMed Central, Scopus, and Google Scholar databases were collected, and abstracts were reviewed for relevance to the subject matter. Epidemiological, pathological, toxicological, genetic, and biochemical studies have all concluded that AD represents a complex network insufficiency. The research studies explored in this manuscript confirm the need for a multifactorial approach to target the various risk factors of AD. A single-drug approach may delay the progression of memory loss but, to date, has not prevented or reversed it. Diet, physical activity, sleep, stress, and environment all contribute to the progression of the disease, and, therefore, a multi-factorial optimization of network support and function offers a rational therapeutic strategy. Thus, a multi-therapeutic program that simultaneously targets multiple factors underlying the AD network may be more effective than a mono-therapeutic approach.

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Section: Multiple Strategies To Optimize Brain Healthmentioning

confidence: 99%

Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer’s Disease and MCI: A Review

Rao¹,

Subramaniam

Gregory³

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…The evaluation of the expression of specific biomarkers (microRNAs, lncRNAs, proteins, etc.) has produced important results for predicting the occurrence/progression of several cancerous [9][10][11][12][13] and non-cancerous [14][15][16] diseases. Moreover, some biomarkers have shown the ability to predict recurrence, chemoresistance, progression and metastasis development in several types of cancers, including ovarian cancer [17][18][19][20][21].…”

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confidence: 99%