Alzheimer's disease in the gut—Major changes in the gut of 5xFAD model mice with ApoA1 as potential key player

Stoye, Nicolai Maximilian; Guilherme, Malena dos Santos

doi:10.1096/fj.201903128rr

Cited by 19 publications

(31 citation statements)

References 118 publications

(220 reference statements)

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“…We organized the latest five years of original research from the angle of gut microbiota, which were all based on the AD animal model, what we found was interesting. Most of these studies used APP/PS1 transgenic mouse as the research subject [62][63][64][65][66][67][68][69][70][71][72], some studies applied 5xFAD mouse [73][74][75][76], there were only two studies collected the data of gut microbiota of SAMP8 mouse [77,78]. As we known, SAMP8 mouse was used to represent sporadic Alzheimer's disease (sAD), which account for over 95% of AD incidence rate [79].…”

Section: Plos Onementioning

confidence: 99%

Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer’s disease animal model

et al. 2021

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Alzheimer’s disease (AD), as one of most common dementia, mainly affects older people from the worldwide. In this study, we intended to explore the possible mechanism of improving cognitive function and protecting the neuron effect by electroacupuncture. Method: We applied senescence-accelerated mouse prone 8 (SAMP8) mice as AD animal model, used Morris water maze, HE staining, 16S rDNA amplicon sequencing of gut microbiota and ELISA to demonstrate our hypothesis. Results: electroacupuncture improved the learning and memory abilities in SAMP8 mice (P<0.05) and could protect the frontal lobe cortex and hippocampus of SAMP8 mice; electroacupuncture significantly decreased the expression of IL-1β (P<0.01), IL-6 (P<0.01) and TNF-α (P<0.01 in hippocampus, P<0.05 in serum) in serum and hippocampus; electroacupuncture balanced the quantity and composition of gut microbiome, especially of the relative abundance in Delta-proteobacteria (P<0.05) and Epsilon-proteobacteria (P<0.05). Conclusion: electroacupuncture treatment could inhibit the peripheral and central nerve system inflammatory response by balancing the gut microbiota.

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Section: Plos Onementioning

confidence: 99%

Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer’s disease animal model

et al. 2021

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“…This may point towards a (transient) increase in susceptibility to local intestinal effects of SiO 2 NMs in the 5xFAD model compared to the C57BL/6J mice. Indeed, in support of this hypothesis, differences in intestinal gene expression, trypsin levels, faecal microbiota composition and associated weight changes have been shown between 5xFAD mice and their wildtype littermates [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 94%

Effects of subchronic dietary exposure to the engineered nanomaterials SiO2 and CeO2 in C57BL/6J and 5xFAD Alzheimer model mice

et al. 2022

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Background There is an increasing concern about the neurotoxicity of engineered nanomaterials (NMs). To investigate the effects of subchronic oral exposures to SiO2 and CeO2 NMs on Alzheimer’s disease (AD)-like pathology, 5xFAD transgenic mice and their C57BL/6J littermates were fed ad libitum for 3 or 14 weeks with control food pellets, or pellets dosed with these respective NMs at 0.1% or 1% (w/w). Behaviour effects were evaluated by X-maze, string suspension, balance beam and open field tests. Brains were analysed for plaque load, beta-amyloid peptide levels, markers of oxidative stress and neuroinflammation. Results No marked behavioural impairments were observed in the mice exposed to SiO2 or CeO2 and neither treatment resulted in accelerated plaque formation, increased oxidative stress or inflammation. In contrast, the 5xFAD mice exposed to 1% CeO2 for 14 weeks showed significantly lower hippocampal Aβ plaque load and improved locomotor activity compared to the corresponding controls. Conclusions The findings from the present study suggest that long-term oral exposure to SiO2 or CeO2 NMs has no neurotoxic and AD-promoting effects. The reduced plaque burden observed in the mice following dietary CeO2 exposure warrants further investigation to establish the underlying mechanism, given the easy applicability of this administration method.

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“…Through literature verification, we find that this list of genes contains many genes experimentally proven to have associations with AD. For example, showed that ALK was important to the tau-mediated AD pathology; Annunziata, et al (2013) showed that the deficiency of NEU1 caused the occurrence of an AD-like amyloidogenic process; Lian, et al (2015) showed that the dysregulation of neuron-glia interaction through NFκB/C3/C3aR signaling may lead to synaptic dysfunction in AD; Rasmussen, et al (2018) confirmed that the low baseline levels of complement C3 were associated with high risk of AD; showed that C4B was differentially expressed in AD; Michele, et al (2017) observed a statistically significant increase of CNVs for C4B in AD patients, suggesting a possible role for C4A CNVs in the risk of AD; Stoye, et al (2020) demonstrated that APOA1 might be a key factor within intestine altered in AD-like pathology. was not certified by peer review) is the author/funder.…”

Section: Discussionmentioning

confidence: 97%

“…Through literature verification, we find that many genes in the list have been proven to have associations with AD. For example, showed that ALK is important to the tau-mediated AD pathology; showed that C4B was differentially expressed in AD; Stoye, et al (2020) demonstrated that APOA1 might be a key factor within intestine altered in AD-like pathology. MTHFR and MAPT have been recorded as related to AD in DisGeNet.…”

Section: Case Studymentioning

confidence: 99%

HyMM: hybrid method for disease-gene prediction by integrating multiscale module structure

Meng

Zhao

et al. 2022

Briefings in Bioinformatics

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Motivation Identifying disease-related genes is an important issue in computational biology. Module structure widely exists in biomolecule networks, and complex diseases are usually thought to be caused by perturbations of local neighborhoods in the networks, which can provide useful insights for the study of disease-related genes. However, the mining and effective utilization of the module structure is still challenging in such issues as a disease gene prediction. Results We propose a hybrid disease-gene prediction method integrating multiscale module structure (HyMM), which can utilize multiscale information from local to global structure to more effectively predict disease-related genes. HyMM extracts module partitions from local to global scales by multiscale modularity optimization with exponential sampling, and estimates the disease relatedness of genes in partitions by the abundance of disease-related genes within modules. Then, a probabilistic model for integration of gene rankings is designed in order to integrate multiple predictions derived from multiscale module partitions and network propagation, and a parameter estimation strategy based on functional information is proposed to further enhance HyMM’s predictive power. By a series of experiments, we reveal the importance of module partitions at different scales, and verify the stable and good performance of HyMM compared with eight other state-of-the-arts and its further performance improvement derived from the parameter estimation. Conclusions The results confirm that HyMM is an effective framework for integrating multiscale module structure to enhance the ability to predict disease-related genes, which may provide useful insights for the study of the multiscale module structure and its application in such issues as a disease-gene prediction.

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Alzheimer's disease in the gut—Major changes in the gut of 5xFAD model mice with ApoA1 as potential key player

Cited by 19 publications

References 118 publications

Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer’s disease animal model

Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer’s disease animal model

Effects of subchronic dietary exposure to the engineered nanomaterials SiO2 and CeO2 in C57BL/6J and 5xFAD Alzheimer model mice

HyMM: hybrid method for disease-gene prediction by integrating multiscale module structure

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