Alzheimer’s Disease: Pathogenesis, Hypothesis and Management

Abstract

its prognosis is not entirely known. With the disease progression, individuals with AD may experience more severe symptoms like uncertainty, disorientation, agitation and behavioral and personality changes (Sano et al., 2023). In addition to cognitive symptoms, AD can also present with behavioral and psychological changes. These changes can include depression, anxiety, irritability, aggression, and psychosis (Heilman and Nadeau, 2022).A person with AD has brain alterations. It becomes smaller with time and has fewer healthy cells. β-amyloid plaques, which are clusters of protein that build up between the nerve cells rather than vanishing as they would in healthy brains and neurofibrillary tangles, which are twisted fibers inside brain cells that obstruct the movement of particles and other essential substances from one part of the cell to another, are two of the pathological Rabia AnjumAlzheimer's Disease: Pathogenesis, Hypothesis and Management