Alzheimer's disease research progress in the Mediterranean region: The Alzheimer's Association International Conference Satellite Symposium

Sexton, Claire E.; Solis, Michele; Aharon‐Peretz, Judith; Alexopoulos, Panagiotis; Apostolova, Liana G.; Bayen, É.; Birkenhager, Betty; Cappa, Stefano F.; Constantinidou, Fofi; Fortea, Juan; Gerritsen, Debby L.; Hassanin, Hany I.; Ibáñez, Agustín; Ioannidis, Panagiotis; Karageorgiou, Elissaios; Korczyn, Amos D.; Leroi, Iracema; Lichtwarck, Bjørn; Logroscino, Giancarlo; Lynch, Chris; Mecocci, Patrizia; Molinuevo, José Luís; Papatriantafyllou, John; Papegeorgiou, Sokratis; Politis, Antonis; Raman, Rema; Ritchie, Karen; Sánchez‐Juan, Pascual; Sano, Mary; Scarmeas, N; Spiru, Luiza; Stathi, Afroditi; Tsolaki, Magda; Yener, Görsev; Zaganas, Ioannis; Zygouris, Stelios; Carrillo, María C.

doi:10.1002/alz.12588

Cited by 3 publications

(1 citation statement)

References 98 publications

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“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a long latency period and irreversibility [1,2]. An estimated 6.7 million Americans age 65 and older are currently living with AD.…”

Section: Introductionmentioning

confidence: 99%

An Electrochemical Immunosensor with PEDOT: PSS/MWCNTs-COOH Nanocomposites as a Modified Working Electrode Material for Detecting Tau-441

Ren,

Liu,

Wei

et al. 2023

Chemosensors

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The progression of Alzheimer’s disease (AD) is positively correlated with the phosphorylation damage of Tau-441 protein, which is the marker with the most potential for the early detection of AD. The low content of Tau-441 in human serum is a major difficulty for the realization of content detection. Herein, we prepared an electrochemical immunosensor modified with Poly(3,4-ethylene-dioxythiophene)-poly (styrene sulfonate) (PEDOT: PSS)/Carboxylated multi-walled carbon nanotube (MWCNTs-COOH) nanocomposites based on electrochemical immunoassay technology for the low-concentration detection of Tau-441. The immunosensor based on the nanocomposite can take advantage of the characteristics of conductive polymers to achieve electrical signal amplification and use MWCNTs-COOH to increase the contact area of the active site and bond with the Tau-441 antibodies on the electrode. The physicochemical and electrical properties of PEDOT: PSS/MWCNTs-COOH were studied by in situ characterization techniques and electrochemical characterization methods, indicating that the immunosensor has high selectivity and sensitivity to the Tau-441 immune reaction. Under optimized optimal conditions, the electrochemical immunosensor detected a range of concentrations of Tau-441 to obtain a low detection of limit (0.0074 ng mL−1) and demonstrated good detection performance through actual human serum sample testing experiments. Therefore, the study provides an effective reference value for the early diagnosis of AD.

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Section: Introductionmentioning

confidence: 99%

An Electrochemical Immunosensor with PEDOT: PSS/MWCNTs-COOH Nanocomposites as a Modified Working Electrode Material for Detecting Tau-441

Ren,

Liu,

Wei

et al. 2023

Chemosensors

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Usability of the Virtual Supermarket Test for Older Adults with and without Cognitive Impairment

Zygouris

Segkouli

Triantafylidis

et al. 2022

Journal of Alzheimer's Disease Reports

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This study conducted a preliminary usability assessment of the Virtual Supermarket Test (VST), a serious game-based self-administered cognitive screening test for mild cognitive impairment (MCI). Twenty-four healthy older adults with subjective cognitive decline and 33 patients with MCI self-administered the VST and then completed the System Usability Scale (SUS). The average SUS score was 83.11 (SD = 14.6). The SUS score was unaffected by age, education, touch device familiarity, and diagnosis of MCI. SUS score correlated with VST performance (r = –0.496, p = 0.000). Results of this study indicate good usability of the VST.

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Dynamic changes and prognostic value of glutathione S-transferase alpha in mild cognitive impairment and Alzheimer’s disease

Tang,

Li,

Dai

et al. 2024

Front. Aging Neurosci.

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ObjectivesGlutathione S-transferase alpha (GSTα) is an important antioxidant enzyme closely associated with the onset and progression of neurodegenerative diseases. The alterations in GSTα protein levels associated with Alzheimer’s disease and their impact on cognitive abilities remain unclear. Thus, investigating the fluctuations of GSTα protein levels in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is essential.MethodsDATA were enrolled from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, and we studied healthy individuals (as controls, a total of 54), patients with mild cognitive impairment (345), and patients with Alzheimer’s disease (96) A one-year follow-up was conducted to collect data on the dynamic changes of GSTα protein levels in plasma and primary information data, and to analyze the correlation between the changes in GSTα protein levels before and after the follow-up and cognitive function and its predictive value.ResultsPlasma GSTα protein levels were significantly lower in the AD group than in the CN group (0.94 vs1.05, p = 0.04) and the MCI group (0.94 vs1.09, p < 0.001). Plasma GSTα protein level changes were positively correlated with altered MMSE levels in MCI and AD patients (r = 0.09, p = 0.04). The AUC (95% CI) of the area under the prediction curve of plasma GSTα protein levels for MCI was 0.63 (0.54–0.71), p = 0.02, and the AUC (95% CI) of the area under the prediction curve of plasma GSTα protein levels for AD was 0.74 (0.69–0.80), p < 0.001. At the same time, we plotted ROC curves for the difference in the change of plasma GSTα protein levels after 1 year of follow-up. The results showed that the AUC (95% CI) of the area under the prediction curve of plasma GSTα protein levels change for MCI was 0.76 (0.696–0.83), p < 0.001, and the AUC (95% CI) of the area under the prediction curve of plasma GSTα protein levels change for AD was 0.75 (0.69–0.80), p < 0.001.ConclusionThe findings of the study indicated notable differences in GSTα protein levels among patients with MCI and those with AD after a one-year follow-up period. Furthermore, a positive correlation was observed between changes in GST αprotein levels and the decline in both baseline and cognitive function. This suggests that GSTα protein could potentially act as a biomarker for both MCI and AD, offering fresh insights for early detection and intervention strategies.

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Alzheimer's disease research progress in the Mediterranean region: The Alzheimer's Association International Conference Satellite Symposium

Cited by 3 publications

References 98 publications

An Electrochemical Immunosensor with PEDOT: PSS/MWCNTs-COOH Nanocomposites as a Modified Working Electrode Material for Detecting Tau-441

An Electrochemical Immunosensor with PEDOT: PSS/MWCNTs-COOH Nanocomposites as a Modified Working Electrode Material for Detecting Tau-441

Usability of the Virtual Supermarket Test for Older Adults with and without Cognitive Impairment

Dynamic changes and prognostic value of glutathione S-transferase alpha in mild cognitive impairment and Alzheimer’s disease

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