2022
DOI: 10.1371/journal.pone.0278774
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Alzheimer’s risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer

Abstract: Increasing evidence from epidemiological studies indicate that Alzheimer’s disease (AD) has a negative relationship with the incidence of cancers. Whether the Alzheimer’s genetic risk factor, named as fermitin family homolog-2 (FERMT2), plays a pivotal part in the progressive process of colorectal carcinoma (CRC) yet remains unclear. This study revealed that FERMT2 was upregulated in CRC tissues which predicted an unfavorable outcome of CRC using the PrognoScan web tool. FERMT2 was co-expressed with a variety … Show more

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Cited by 4 publications
(3 citation statements)
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“…FERMT2 has been found to interact with integrins to regulate many physiopathological processes; most notably, FERMT2 has been identified as being associated with amyloid precursor protein (APP) metabolism, which is a significant risk factor for Alzheimer's disease (AD) [65]. On the other hand, FERMT2 has been identified as a novel oncogene that is highly expressed tumors, including breast, pancreatic, and colorectal cancers, and promotes invasion and metastasis [34,36,66,67]. GC contains a rich tumor microenvironment in which nontransformed components (particularly fibroblasts and macrophages) are thought to be important components of the tumor supporting microenvironment [68,69].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…FERMT2 has been found to interact with integrins to regulate many physiopathological processes; most notably, FERMT2 has been identified as being associated with amyloid precursor protein (APP) metabolism, which is a significant risk factor for Alzheimer's disease (AD) [65]. On the other hand, FERMT2 has been identified as a novel oncogene that is highly expressed tumors, including breast, pancreatic, and colorectal cancers, and promotes invasion and metastasis [34,36,66,67]. GC contains a rich tumor microenvironment in which nontransformed components (particularly fibroblasts and macrophages) are thought to be important components of the tumor supporting microenvironment [68,69].…”
Section: Discussionmentioning
confidence: 99%
“…The kindlin or fermitin (FERMT) family is a group of adapter or scaffold proteins with names defined by the 4.1 protein, ezrin, radixin, and moesin (FERM) structural domains that mediate transmembrane integrin adhesion receptor signaling by acting in concert with talin [ 31 , 32 ]. FERMTs comprise three members: FERMT1 is restrictedly expressed on epithelial cells, FERMT2 is widely expressed, and FERMT3 is predominantly located in the hemopoietic system [ 33 , 34 ]. FERMT2 has been found to be implicated in tumor pathogenesis and is highly expressed in a variety of cancers, including breast and colorectal cancers [ 35 , 36 ].…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, studies have indicated that the elevated level of FERMT2 can promote local progression and metastasis of tumor in oral cancer as well as gallbladder cancer by modulating epithelial-mesenchymal transition (EMT) [ 19 , 20 ]. Furthermore, in colorectal cancer, FERMT2 can affect EMT of cancer cells through the activation of Wnt/β-catenin signaling pathway, thus influencing tumor advancement [ 21 ].…”
Section: Introductionmentioning
confidence: 99%