Am J Reprod Immunol 2007; 58:447–459. Decline in Number of Elevated Blood CD3<sup>+</sup> CD56<sup>+</sup> NKT Cells in Response to Intravenous Immunoglobulin Treatment Correlates with Successful Pregnancy

Heuvel, MJ Van Den; Peralta, CG; Hatta, Kota; Han, VK; Clark, DA

doi:10.1111/j.1600-0897.2007.00545.x

Cited by 5 publications

(2 citation statements)

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“…The leptin-induced increase in the percentage of CD16 + 56 + NKT cells at the late stages of gestation probably refl ects the induction of phenotypic maturation of NKT cells. Published data show that the formation of this phenotype occurs at the fi nal stage of NKT cell activation and is associated with acquisition of the highest cytotoxic activity [10,13]. It should be emphasized that NKT cells constitute a subpopulation of regulatory T lymphocytes.…”

Section: Resultsmentioning

confidence: 99%

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Leptin as an Immunocorrecting Agent during Normal Pregnancy

Орлова

Shirshev

2009

Bull Exp Biol Med

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Experiments were performed with leptin in doses observed during pregnancy. We studied the effect of leptin on expression of membrane molecules and cytokine production by peripheral blood mononuclear cells from women. Leptin increased the expression of HLA-DR on T lymphocytes, stimulated the production of TNF-alpha and IL-6, and did not affect secretion of IL-2, IL-4, and IL-10 by mononuclear leukocytes. Leptin in a dose comparable to that during the 1st trimester of pregnancy increased the percentage of NK cells with membrane CD16 and CD56, stimulated the production of IFN-alpha by mononuclear leukocytes, and did not modulate the number of CD16(+)56(+)NKT cells. Treatment with leptin in a dose for the second-third trimesters of pregnancy was followed by a decrease in the percentage of CD16(+)56(+)NKT cells and increase in the number of NKT cells expressing CD16 and CD56. Our results indicate that leptin play an important role in the regulation of membrane molecule expression and cytokine production by mononuclear leukocytes.

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Section: Resultsmentioning

confidence: 99%

“…Activation of these cells is followed by secretion of considerable amounts of IFN-γ and IL-4. In addition to dendritic cells, these cells play the major role in Th1/ Th2 deviation and development of peripheral tolerance [3,10,12]. Peripheral blood NKT cells are important for implantation.…”

Section: Resultsmentioning

confidence: 99%

Leptin as an Immunocorrecting Agent during Normal Pregnancy

Орлова

Shirshev

2009

Bull Exp Biol Med

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Immune regulatory network in successful pregnancy and reproductive failures

Ghaebi

Nouri

Ghasemzadeh

et al. 2017

Biomedicine & Pharmacotherapy

110

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Reappraisal of peripheral NK cells in women with recurrent miscarriage

Wang¹,

Li²,

Wu³

et al. 2008

Reproductive BioMedicine Online

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The aim of this study was to examine the relationship between peripheral natural killer (NK) cells and recurrent miscarriage by improved methods. Peripheral NK cell measurement was carried out using flow cytometry of morning blood samples obtained in the early follicular phase, analysed within 8 h of collection. Eighty-five Chinese women with recurrent miscarriage who previously tested negative for autoantibodies, and 27 control subjects who were not using any hormonal methods for contraception, were recruited. No significant difference was found in the number of peripheral NK cells and their subsets between women with recurrent miscarriages and control subjects. Only 5% of women with recurrent miscarriage had high peripheral NK cells. The number of previous miscarriages did not appear to have an impact on the number of NK cells. In conclusion, there appears to be limited value in the routine measurement of peripheral NK cells in women with recurrent miscarriage.

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Am J Reprod Immunol 2007; 58:447–459. Decline in Number of Elevated Blood CD3⁺ CD56⁺ NKT Cells in Response to Intravenous Immunoglobulin Treatment Correlates with Successful Pregnancy

Abstract: In the above paper, 1 the following error was published on p. 451 in the legend to Fig. 1

Cited by 5 publications

References 1 publication

Leptin as an Immunocorrecting Agent during Normal Pregnancy

Leptin as an Immunocorrecting Agent during Normal Pregnancy

Immune regulatory network in successful pregnancy and reproductive failures

Reappraisal of peripheral NK cells in women with recurrent miscarriage

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Am J Reprod Immunol 2007; 58:447–459. Decline in Number of Elevated Blood CD3+ CD56+ NKT Cells in Response to Intravenous Immunoglobulin Treatment Correlates with Successful Pregnancy

Abstract: In the above paper, 1 the following error was published on p. 451 in the legend to Fig. 1

Cited by 5 publications

References 1 publication

Leptin as an Immunocorrecting Agent during Normal Pregnancy

Leptin as an Immunocorrecting Agent during Normal Pregnancy

Immune regulatory network in successful pregnancy and reproductive failures

Reappraisal of peripheral NK cells in women with recurrent miscarriage

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Am J Reprod Immunol 2007; 58:447–459. Decline in Number of Elevated Blood CD3⁺ CD56⁺ NKT Cells in Response to Intravenous Immunoglobulin Treatment Correlates with Successful Pregnancy