Rheumatoid arthritis (RA) is a chronic immuno-inflammatory systemic disorder of synovial joints. The major complaints for which a patient seeks medical attention are pain in and around the joints, swelling, stiffness and limited range of motion. A disease resembling clinically to RA is described in Ayurvedic texts as Amavata. The Ayurvedic treatment not only devoid such type of ill effect, but also provides a better way by treating Agni and Ama at its roots. Rasna Saptak Kwath (RSK) is a formulation which is prescribed to the patient in decoction form to treat arthritis. The description of RSK to treat amavata (Rheumatoid arthritis) is found in Bhaishajya Ratnavali. RSK is a formulation of eight herbs viz. Pluchea lanceolata,, Tribulus terristris, Tinospora cardifolia, Boerrihia diffusa, Ricinus communis, Cedrus deodara, Cassia fistula and Zingiber officinale. Researches revealed that these herbs play significant role in reducing the symptoms and to treat the RA. The herbs possess the property of anti-inflammation, analgesic, antioxidant, immunosuppressive activity. Maximum ingredients of RSK have Vatasleshmahara property which reduces Vata and Kapha Doshas from the body and reduces the symptoms of amavata. So, this paper will give a comparative view on probable pharmacology (pharmacokinetic and pharmacodynamic activity) of the formulation through Ayurvedic and contemporary approach.