Amantadine in Chinese ‘Cold and Flu’ tablets: the cause of psychosis in a healthy man

Turbayne, Alexander K. B.; Xu, Tina T.; Swaminathan, Ashwin

doi:10.1111/imj.13780

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…The latest paper covers the case of a healthy 22-yeard-old Chinese man presenting with severe drug-induced psychosis after the intake of an over-the-counter (OTC) Chinese 'Cold and Flu' medication containing amantadine. The patient presented symptoms such as disorientation, sleep disturbance, increasing agitation, visual hallucinations, persecutory auditory hallucinations, and disordered thought [15].…”

Section: Discussionmentioning

confidence: 99%

Amantadine toxic effect and acute psychosis – a case report

Gruca

Krzysztof

Marcin

et al. 2023

J Educ Health Sport

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Introduction and purpose: The pandemic of COVID-19 has induced patients to use different ways to struggle with SARS-CoV-2 infection. Amantadine has become more popular as a supportive drug in the treatment of COVID-19 symptoms. This report presents a case of a young, previously healthy woman hospitalized in the Toxicology and Cardiology Department because of acute psychosis induced by amantadine intoxication. Brief description of the state of knowledge: Several medications, including psychostimulants, antibiotics, antivirals, and antiparkinsonians can cause acute psychosis. Amantadine has primarily dopaminergic with some anticholinergic properties and is used predominantly as an adjuvant agent in the management of Parkinson's disease treatment. Psychomotor agitation, insomnia, excessive verbosity, delusions, and behavioral disturbances are typical toxic effects of amantadine primarily affecting the central nervous system presented by the patient described in this case report. Conclusions: Our case illustrates the adverse effects of amantadine on the central nervous system when given at the recommended dose to young, healthy women. Despite being rare, this induced psychosis may become more common, especially while becoming more popular as a supportive drug in COVID-19 treatment. While prescribing amantadine clinicians should be aware of the rapid onset of its psychotic complications.

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Section: Discussionmentioning

confidence: 99%

Amantadine toxic effect and acute psychosis – a case report

Gruca

Krzysztof

Marcin

et al. 2023

J Educ Health Sport

View full text Add to dashboard Cite

show abstract

“…Bupropion and amantadine are generally well tolerated and often prescribed for ADHD and depressive disorders. There are a number of reports in the literature about emergence of psychotic symptoms with both bupropion and amantadine when prescribed as monotherapy in adults 3–5 . Seizures are a well-documented adverse effect with bupropion in therapeutic and supratherapeutic doses and in acute overdose.…”

Section: Discussionmentioning

confidence: 99%

“…However, in mild to moderate overdose, it can cause hallucinations and/or delusions, tachycardia, and tremors 6 . There is a report of new onset of acute severe psychotic symptoms in a healthy man from China after taking supratherapeutic doses of an over-the-counter medication containing amantadine 4 . There is also a case series of bupropion-amantadine–associated neurotoxicity among geriatric patients with depression and mild to moderate cognitive impairment who were on a stable dose of bupropion.…”

Section: Discussionmentioning

confidence: 99%