Amaranth proteins as potential source of bioactive peptides with enhanced inhibition of enzymatic markers linked with hypertension and diabetes

Kamal, Hina; Mudgil, Priti; Bhaskar, Bincy; Fisayo, Ajayi Feyisola; Gan, Chee-Yuen; Maqsood, Sajid

doi:10.1016/j.jcs.2021.103308

Cited by 41 publications

(25 citation statements)

References 51 publications

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“…Intact protein (API) displayed dense prominent bands over a wide range of molecular weight. Major protein bands detected in electrophoretic pattern of amaranth proteins have been reported to be globulin, albumin, glutelins, prolamin ( Kamal et al, 2021 , Sandoval-Sicairos et al, 2021 ). The protein profile of the amaranth reported in this study was similar to that of previously reported by Martínez and Anon (1996).…”

Section: Resultsmentioning

confidence: 99%

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Identification and characterization of cholesterol esterase and lipase inhibitory peptides from amaranth protein hydrolysates

et al. 2021

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Highlights Gastric, microbial and plant-based enzymes were used to produce Amaranth protein hydrolysates (APHs). APHs displayed enhanced cholesterol esterase (CEase) and pancreatic lipase (PL) inhibitory activities. Bromelain generated hydrolysates showed the highest CEase and PL inhibitory activity. FPFPPTLGY, FGAPR, and FPFVPAPT were predicted as potential PL inhibitors and FPFVPAPT as CEase inhibitor.

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Section: Resultsmentioning

confidence: 99%

“…Electrophoretic pattern of API and APHs were determined by SDS-PAGE under reducing condition following the method described by Kamal et al (2021) .…”

Section: Methodsmentioning

confidence: 99%

Identification and characterization of cholesterol esterase and lipase inhibitory peptides from amaranth protein hydrolysates

et al. 2021

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“…Thus, intact walnut protein at 500 µg/mL showed DPP-IV inhibition rates lower than 5% [ 55 ]. In another recent study, low DPP-IV inhibitory activity was also reported for undigested amaranth protein isolate as reflected by an IC 50 value of 8.22 mg/mL [ 56 ]. Similarly, a previous study had reported low DPP-IV inhibitory effects for intact amaranth glutelins [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Albumin from Erythrina edulis (Pajuro) as a Promising Source of Multifunctional Peptides

et al. 2021

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Multifunctional peptides, capable of acting on different body systems through multiple mechanisms of action, offer many advantages over monofunctional peptides, including lower adverse side effects and costs. Erythrina edulis (pajuro) is a legume with a large number of high-quality proteins, of which their potential as a source of antioxidant peptides has been recently reported. In this study, the behavior of these proteins under a sequential enzymatic hydrolysis with digestive and microbial enzymes was investigated by evaluating the multi-functionality of the hydrolyzates. The albumin hydrolyzates obtained after the action of pepsin, pancreatin, and Alcalase showed antioxidant, angiotensin-converting enzyme (ACE), α-amylase, α-glucosidase, and dipeptidyl peptidase (DPP)-IV inhibitory activities. The radical scavenging properties of the hydrolyzate could be responsible for the potent protective effects observed in FeSO4-induced neuroblastoma cells. The findings support the role of pajuro protein as an ingredient of functional foods or nutraceuticals for health promotion and the prevention of oxidative stress, hypertension, and metabolic alteration-associated chronic diseases.

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“…Enzymatic modification is recently applied as a useful tool to improve the functionality and biological activity of amaranth protein. Kamal et al [14] prepared amaranth protein hydrolysates using bromelain, chymotrypsin, and pronase E enzymes at three different hydrolysis durations (2, 4, and 6 h). Bioactive peptides were identified by LC-MS-QToF analysis.…”

Section: Amaranth Proteinmentioning

confidence: 99%

“…Bioactive peptides were identified by LC-MS-QToF analysis. Amaranth protein hydrolysates were reported to contain bioactive peptides with inhibitory properties against enzymatic markers linked with hypertension and diabetes [14].…”

Section: Amaranth Proteinmentioning

confidence: 99%

Proteins from Pseudocereal Grains

Karaça¹

2022

Pseudocereals

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Seeds such as quinoa, amaranth, chia, and teff are considered as potential sources of plant-based proteins for human consumption. Proteins isolated from pseudocereal grains have the potential to serve as nutritious alternatives to animal-based proteins for various food applications. Quinoa, amaranth, and chia proteins are among the most extensively studied pseudocereal proteins for the characterization of structural, physicochemical, and functional properties. This chapter will review the recent studies on composition, structural characteristics, physicochemical and functional properties of proteins isolated from pseudocereal grains, will discuss several modifications applied for improvement of functional properties and some potential end-product applications.

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Amaranth proteins as potential source of bioactive peptides with enhanced inhibition of enzymatic markers linked with hypertension and diabetes

Cited by 41 publications

References 51 publications

Identification and characterization of cholesterol esterase and lipase inhibitory peptides from amaranth protein hydrolysates

Identification and characterization of cholesterol esterase and lipase inhibitory peptides from amaranth protein hydrolysates

Albumin from Erythrina edulis (Pajuro) as a Promising Source of Multifunctional Peptides

Proteins from Pseudocereal Grains

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