Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats

Abstract

Amaranthus spinosus is a common vegetable of Bangladesh and well-known for its ethnomedicinal uses. In this study, we have evaluated the ability of powdered supplementation, methanol extract, and aqueous extract of A. spinosus in attenuating in high-carbohydrate-high-fat (HCHF) diet-induced obesity and associated metabolic disorders in female obese rates. Several parameters have been analyzed in this study including body weight, organ weight, fat deposition, glycemic status, lipid levels, hepatic and renal biomarkers, hepatic antioxidant status, and hepatosteatosis. All three samples of A. spinosus significantly reduced weight gain, organ weight, and abdominal fat deposition. Improved glucose tolerance and lipid parameters were seen in obese rats administered with A. spinosus powder, methanol extract, and aqueous extract. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatine kinase levels were normalized by the test samples. A. spinosus boosted hepatic antioxidant levels including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Histopathology of liver tissue revealed increased fat infiltration and higher steatosis score in HCHF diet-fed obese rats which was brought down by A. spinosus. Analyzing all the results it can be concluded that this medicinal herb is beneficial in the management of obesity and obesity-induced metabolic disorders, making it a prospective food supplement.

Unripe banana flour ( Musa cavendishii ) promotes increased hypothalamic antioxidant activity, reduced caloric intake, and abdominal fat accumulation in rats on a high‐fat diet

“…The development of hyperphagia with HFD is strongly associated with weight gain, fat mass accumulation, and obesity, as has been reported in other studies (Belobrajdic et al, 2012; Natal & Ribeiro, 2016). The HFD group showed higher energy intake and feed efficiency, leading to an accumulation of abdominal fat mass, which is the main feature of obesity development (Dentz et al, 2021; González‐Muniesa et al, 2017; Prince et al, 2021; Romieu et al, 2017). In addition, the analysis of caloric intake and the accumulation of adipose tissue shows that there is a strong positive correlation between these two variables (Sifat et al, 2020).…”

Epigenetics and mitochondrial dysfunction insights into the impact of the progression of non‐alcoholic fatty liver disease

“…Furthermore, miR‐33 deficiency improves glucose homeostasis and inhibits the development of inflammation as well as fibrosis. Even documentation confirms miR‐33's role in obesity and metabolic dysfunction 79 . Obese females in two categories, severely obese and moderately obese, were studied to confirm the link between miR‐33 and lipid metabolism in NAFLD.…”

“…Even documentation confirms miR-33's role in obesity and metabolic dysfunction. 79 Obese females in two categories, severely obese and moderately obese, were studied to confirm the link between miR-33 and lipid metabolism in NAFLD. Apart from miR-33's significance, this study conclusively established the link between miR-122 and this health concern.…”

Potential of enhancing anti-obesogenic agriceuticals by applying sustainable fertilizers during plant cultivation

“…A. caudatus grown with 50 ppm of AgNPs led to the highest flavonoid composition, being kaempferol and quercetin the most abundant flavonoids in A. caudatus. Various authors have associated the phenolic and flavonoid content of Amaranthus species with anti-obesogenic activity (Kanikowska et al, 2019;Yuniarto et al, 2020;Prince et al, 2021). Prince et al (2021) observed significant reductions in weight gain, organ weight, abdominal fat deposition, liver fat infiltration and steatosis, and improvements in glucose tolerance, hepatic antioxidant levels, and lipid parameters in high-carbohydrate-high-fat diet-fed obese rats administered with Amaranthus powder.…”

“…Various authors have associated the phenolic and flavonoid content of Amaranthus species with anti-obesogenic activity (Kanikowska et al, 2019;Yuniarto et al, 2020;Prince et al, 2021). Prince et al (2021) observed significant reductions in weight gain, organ weight, abdominal fat deposition, liver fat infiltration and steatosis, and improvements in glucose tolerance, hepatic antioxidant levels, and lipid parameters in high-carbohydrate-high-fat diet-fed obese rats administered with Amaranthus powder. Table 2 includes other studies where nanofertilization improves the agriceutical composition of antiobesogenic plants.…”