Amaryllidaceae alkaloids from the bulbs of Crinum latifolium L. and their cholinesterase inhibitory activities

Chaichompoo, Waraluck; Rojsitthisak, Pornchai; Pabuprapap, Wachirachai; Siriwattanasathien, Yuttana; Yotmanee, Pathumwadee; Suksamrarn, Apichart

doi:10.1016/j.phytochem.2023.113929

Phytochemistry

2024

DOI: 10.1016/j.phytochem.2023.113929

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Amaryllidaceae alkaloids from the bulbs of Crinum latifolium L. and their cholinesterase inhibitory activities

Waraluck Chaichompoo,

Pornchai Rojsitthisak,

Wachirachai Pabuprapap

et al.

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2024

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Cited by 2 publications

References 60 publications

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Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity

Křoustková,

Kohelová,

Muthná

et al. 2024

J. Nat. Prod.

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This phytochemical study presents the isolation of eight alkaloids from Zephyranthes citrina Baker. The structures of the new alkaloids, zephycitrine (1) and 6-oxonarcissidine (2), were established by analysis of spectroscopic and spectrometric data. Processing the EtOH extract under acid−base conditions yielded the unreported isolation artifacts 3 and 4. This work also provides analytical data for alkaloids not properly described in the literature (5 and 6). The hippeastidine/zephyranine scaffolds in derivatives 3, 4, and 8−10 are also thoroughly discussed. Furthermore, a cytotoxicity screening of 25 Amaryllidaceae alkaloids isolated from Z. citrina was performed. Only the known alkaloids haemanthamine (12), haemanthidine (13), and lycorine (27) showed significant cell growth inhibition.

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Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity

Křoustková,

Kohelová,

Muthná

et al. 2024

J. Nat. Prod.

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Navigating Amaryllidaceae alkaloids: bridging gaps and charting biosynthetic territories

Liyanage,

Awwad,

Gonçalves dos Santos

et al. 2024

Journal of Experimental Botany

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Amaryllidaceae alkaloid (AAs) biosynthesis has garnered significant attention in recent years, particularly with the commercialisation of galanthamine as a treatment for the symptoms of Alzheimer’s disease. A significant amount of research work over the last 8 decades has focused on the understanding of AA biosynthesis, starting from early radiolabelling studies to recent multi-omics analysis with modern biotechnological advancements. Those studies enabled the identification of hundreds of metabolites, the characterisation of biochemical pathway, an understanding of the environmental stimuli, and of the molecular regulation of these pharmaceutically and agriculturally important metabolites. Despite the numerous works there remain significant gaps in understanding their biosynthesis in Amaryllidaceae plants. As such, further research is needed to fully elucidate the metabolic pathway and facilitate their production. This review aims to provide a comprehensive overall summary of the current state of knowledge on AAs biosynthesis, from elicitation of transcription factors expression in the cell nucleus to alkaloid transport in the apoplast, and to highlight the challenges that need to be overcome for further advancement.

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Amaryllidaceae alkaloids from the bulbs of Crinum latifolium L. and their cholinesterase inhibitory activities

Cited by 2 publications

References 60 publications

Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity

Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity

Navigating Amaryllidaceae alkaloids: bridging gaps and charting biosynthetic territories

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