Amaryllidaceae and Sceletium alkaloids

Abstract

This review covers the isolation, biological activity and chemical synthesis of Amaryllidaceae alkaloids and the structurally related Sceletium alkaloids. The literature from July 2001 to the end of 2002 is reviewed, and 61 references are cited.

Chapter 3 Chemical and Biological Aspects of Narcissus Alkaloids

“…Regarding co-evolutionary adaptation, a notable example is the elaboration of a new conjugate alkaloid (telastasine) by the insect Polytela gloriosa Fab. These alkaloids, essential for plant survival, have a wide range of interesting physiological effects, including antitumor, antiviral, acetylcholinesterase inhibitory, immunostimulatory, and antimalarial activities, some of them being of particular interest because of their potential use in clinical therapy (34). Plants and insects use the same detoxification mech anism.…”

“…The history of the Amaryllidaceae alkaloids, their structural elucidation, and their biological profiles, as well as their synthesis, have been summarized on several occasions (20,33,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) which, together with the regular publications in the journal Natural Product Reports (34,(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66), represent a valuable source of information.…”

“…An exhaustive report is beyond the scope of this chapter, and the reader is referred to recent and excellent reviews in the field for a more thorough account (34,(60)(61)(62)(63)(64)(65)(66)210,211). An exhaustive report is beyond the scope of this chapter, and the reader is referred to recent and excellent reviews in the field for a more thorough account (34,(60)(61)(62)(63)(64)(65)(66)210,211).…”

De novo Sequence Assembly and Characterization of Lycoris aurea Transcriptome Using GS FLX Titanium Platform of 454 Pyrosequencing

“…Moreover, Lycoris species are all of medical values. The bulbs of Lycoris have been used in traditional Chinese medicine (TCM) for a long time and some Amaryllidaceae-type alkaloids isolated from these plants have been reported to exhibit immunostimulatory, anti-tumor, anti-viral and anti-malarial activities [4][5][6][7]. For example, lycorine, a pyrrolophenanthridine alkaloid, has been demonstrated to suppress cell growth of the human leukemia cell line HL-60 [8] as well as the multiple myeloma cell line KM3 [9] by arresting the cell cycle, subsequently inducing apoptosis of tumor cells.…”

Advances in Solution- and Solid-Phase Synthesis toward the Generation of Natural Product-like Libraries

“…[228][229][230] (+)-Plicamine and its enantiomer have an intriguing tetracyclic architecture with the 6,6-spirocyclic core with two skeletal nitrogens. Both of these isomers were synthesized using the solid-supported reagents and scavengers in multistep reaction sequences by Ley and co-workers.…”