Amaryllidaceae, Sceletium, imidazole, oxazole, thiazole, peptide and miscellaneous alkaloids

Abstract

This review covers alkaloids classified in the plant families Amaryallidaceae and Sceletium. In addition alkaloids possessing imidazole, oxazole and thiazole structures are listed followed by alkaloids possessing peptide linkages. Finally miscellaneous alkaloids include those compounds found naturally which cannot be classified into known groups; a relative Pandora's box. A total of 620 structures has been reviewed from 218 references found in the literature for the period July 1999 to June 2000.

Analysis of Amaryllidaceae alkaloids from Narcissus by GC–MS and capillary electrophoresis

“…The isolated haemanthamine (10 mg) was found to be pure by LC-MS analysis. 1 H NMR spectrum of haemanthamine was recorded in CDCl 3 on a Varian Gemini (200 MHz) NMR spectrometer, using TMS as the internal standard. The chemical shift is expressed in δ (ppm) and J in Hz: 1H, s, Ar).…”

“…In the recent years attention has been focused on the biological activity of several Amaryllidaceae alkaloids [1] which displayed antimalarial [2,3], antiviral [4,5] and antiproliferative activity [6]; the most important Amaryllidaceae alkaloid is undoubtedly galanthamine that is approved for the pharmacological treatment of Alzheimer's disease [7].…”

Synthesis and Antitumor Activity of the Thiazoline and Thiazine Multithioether

“…Furthermore, the optically active heterocyclic compounds have been successfully used in asymmetric synthesis as chiral templates [4,5] or ligands [6][7][8][9] reported the synthesis of thioethers and thioesters in acetonitrile. Herein, we reported an efficient synthesis of some thiazoline and thiazine multithioethers in a friendly solvent-ethanol and explored the biological activities of the obtained target products against A549 (human lung cancer cell) and Bcap-37 (human breast cancer cell).…”

Vibrational spectroscopic investigations of 4,4-dimethyl-2-oxazoline: A density functional theory approach

“…The extreme limits of the electron density observed in DMOZ is À4.824eÀ2 (red) and 4.824eÀ2 (blue), where blue indicates the strongest attraction and red indicates the strongest repulsion. The negative (red and yellow) regions of MEP were related to electrophilic reactivity and the 1 For interpretation of color in Fig. 7, the reader is referred to the web version of this article.…”

“…Besides, additional functionalities can readily be introduced into 2-oxazolines via functional monomers units and these compounds fulfil fundamental requirements for an application as carrier molecules in radionuclide therapy. Recent studies have shown that highly active sugar oxazoline act as donor substrates for transglycosylation and exhibit potent anti-HIV activity [1][2][3][4][5]. Oxazoline analogues have also been shown to induce cell growth inhibition, apoptosis, and microtubule disruption without alkylating beta-tubulin [6].…”