Amazonia Products in Novel Lipid Nanoparticles for Fucoxanthin Encapsulation

Cordenonsi, Leticia Malgarim; Santer, Andressa; Sponchiado, Rafaela Martins; Wingert, Nathalie Ribeiro; Raffin, Renata Platcheck; Schapoval, Elfrides Eva Scherman

doi:10.1208/s12249-019-1601-y

Cited by 13 publications

(7 citation statements)

References 36 publications

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“…This comportment could be explained by change of physical-chemical characteristics Table 2. ATR-FTIR spectrum analysis for all samples [35,37,38] .…”

Section: Resultsmentioning

confidence: 99%

“…Besides that, the simplicity of the extraction process to obtain the oil, which is mainly based on mechanical cold-pressing [34] , also turns it into a promising biotechnological resource. In this view, tucuma oil has been already used in the biomedical field due to the high fatty acids content and the fact it has several carotenoids as bioactive compounds [35] . Based on the aforementioned, its incorporation into electrospun biomaterials trends to improve biocompatibility in addition to physical-chemical properties [36][37][38][39][40] .…”

Section: Introductionmentioning

confidence: 99%

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Incorporation of astrocaryum vulgare (tucuma) oil into PCL electrospun fibers

et al. 2021

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The aim of this study was to incorporate tucuma oil (Astrocaryum vulgare) into PolyCaprolactone (PCL) electrospun fibers and evaluate its physicochemical properties and cell viability. FTIR and DRX confirmed that tucuma oil (TO) does not affect the chemical properties of PCL and that the oil was loaded into the PCL microstructure, while TGA analysis showed that the oil increased the thermal stability of the polymeric fibers. SEM showed that the addition of the oil modified fibers structure by reducing the average fiber size from 5.5 μm to 1.7 μm for TO loaded samples. Cell viability assay demonstrated an increment on cell proliferation from 80% of pure PCL to 100% for samples containing TO. Therefore, it can be concluded that tucuma oil can be incorporated into PCL to form fibers by electrospinning, without meaningful changes in its physicochemical properties and increasing its biocompatibility.

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“…This comportment could be explained by change of physical-chemical characteristics Table 2. ATR-FTIR spectrum analysis for all samples [35,37,38] .…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incorporation of astrocaryum vulgare (tucuma) oil into PCL electrospun fibers

et al. 2021

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“…specie was found in this work, as shown in Tables S3 and S4, Supporting Information. [75][76][77][78][79][80][81][82][83] This specie, called tucumã-dopará, grows in the eastern Brazilian Amazon, French Guiana, and Suriname. [34] This variety can reach 10 to 15 m in height and 15 to 20 cm in diameter.…”

Section: Tucumã Pulp Oil and Kernel Fat Scientific Production Overviewmentioning

confidence: 99%

Current Scenario and Recent Advancements from Tucumã Pulp Oil and Kernel Fat Processing

Ferreira

Mota

Mariano

et al. 2022

Euro J Lipid Sci & Tech

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According to the Food and Agricultural Policy Research Institute, the demand for edible oils and fats is growing. Tucumã is a native Amazonian fruit with high lipids content in the pulp and kernel. The pulp oil has a high content of unsaturated fatty acids and carotenoids, mainly 𝜷-carotene, a pro-vitamin A. Kernel fat has high oxidative stability as it is rich in saturated fatty acids, with a predominance of lauric acid. Tucumã pulp oil and kernel fat can formulate functional fats due to their physicochemical, nutritional, and sensory properties. This paper aims to provide an overview of intellectual property and academic production about tucumã oil and fat. The increase in scientific production from 2001 to 2020 indicates that the research institutes have expanded interest in tucumã fruit. However, intellectual property using tucumã oil and fat for industrial applications is still modest. Using the selected keyword combinations, nineteen and ten papers related to pulp oil and kernel fat are met, respectively. The United States leads the patents publications related to tucumã fruit, oil, and fat (45%). Most patents are directed to the cosmetic and pharmaceutical sectors (59%), demonstrating the necessity for studies focused on applications in the food industry. Practical Applications: Tucumã pulp oil and kernel fat can be used to formulate functional fats due to their physicochemical, nutritional, and sensory properties. The tucumã pulp oil has a high content of unsaturated fatty acids and carotenoids, mainly 𝜷-carotene, a pro-vitamin A. The tucumã kernel fat presents high oxidative stability as it is rich in saturated fatty acids, with a predominance of lauric acid. Most patents are directed to the cosmetic and pharmaceutical sectors, which demonstrate the need for studies focused on the food industry. The small number of patents favors promising partnerships between companies and scientific institutions for the transfer of academic knowledge of new technologies applied in the food industry.

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“…Thus, inflammatory skin diseases can be successfully treated by the localized release of actives through NLC, more efficiently than conventional formulations. These nanosystems may improve the anti-inflammatory properties of the active by increasing its permeation through (i) targeted epidermal delivery, (ii) stratum corneum surface modification after contact of the nanocarrier’s components and the corneocytes, (iii) nanoparticle’s adherence to the skin surface by the occlusion effect, which leads to a controlled release of the active, and (iv) enhanced active concentration by increasing the solubility of the incorporated actives, among others [ 18 , 20 , 61 ].…”

Section: Nanostructured Lipid Carriers (Nlc)mentioning

confidence: 99%

“…This carotenoid has anti-inflammatory and antioxidant activities and was incorporated in NLC by Cordenonsi and co-workers (2019). Besides good physicochemical properties, the skin porcine permeation study showed specific and linear NLC distribution without transdermal delivery [ 61 ].…”

Section: Nlc Containing Natural Substances Against Skin Inflammationmentioning

confidence: 99%

Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

et al. 2021

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The main function of the skin is to protect the body from the external environment. However, the skin can undergo inflammatory processes, due to genetic, hormonal, or environmental factors. When the defense system is overloaded, there is an increase in pro-inflammatory mediators and reactive oxygen species (ROS), which results in skin disorders. Among the substances used to treat these inflammatory processes, many natural substances with anti-inflammatory and antioxidant properties are being studied: nature is yet an abundant source to obtain diverse pharmacological actives. The treatment of skin diseases is usually focused on topical application, as it reduces the risk of systemic side effects and prevents drug degradation by first-pass metabolism. Thus, the properties of drug delivery vehicles can facilitate or inhibit its permeation. Due to the hydrophobic nature of the skin, a promising strategy to improve dermal drug penetration is the use of lipid-based nanoparticles, such as nanostructured lipid carriers (NLC). Therefore, in this review, we present NLC as a tool to improve dermal administration of natural substances with anti-inflammatory properties.

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Amazonia Products in Novel Lipid Nanoparticles for Fucoxanthin Encapsulation

Cited by 13 publications

References 36 publications

Incorporation of astrocaryum vulgare (tucuma) oil into PCL electrospun fibers

Incorporation of astrocaryum vulgare (tucuma) oil into PCL electrospun fibers

Current Scenario and Recent Advancements from Tucumã Pulp Oil and Kernel Fat Processing

Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

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