Ambient air pollution and incidence of early-onset paediatric type 1 diabetes: A retrospective population-based cohort study

Elten, Michael; Donelle, Jessy; Lima, Isac; Burnett, Richard T.; Weichenthal, Scott; Stieb, David M.; Hystad, Perry; Donkelaar, Aaron van; Chen, Hong; Paul, Lauren A.; Crighton, Eric; Martin, Randall V.; Decou, Mary Lou; Luo, Wei; Lavigne, Éric

doi:10.1016/j.envres.2020.109291

Cited by 30 publications

(21 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We identified a few very recent reports supporting our results; Hathout et al reported on evidence suggesting that cumulative exposure to ozone, O 3 , and sulfate in ambient air may predispose children to the development of T1D 12) . In a retrospective, population-based cohort study from Ontario, Canada, Elten et al also showed that exposure to O 3 during a critical period of development was associated with an increased risk of pediatric diabetes incidence up to 6 years of age 30) . In Bavaria, Germany, exposure to high levels of PM 10 and NO 2 was associated with a shift in the 10th percentile of the age of T1D diagnosis to lower values, suggesting their role in accelerating disease manifestation 16) .…”

Section: Discussionmentioning

confidence: 99%

Correlation between total air pollutant emissions and incidence of type 1 diabetes in the Russian Federation

et al. 2021

View full text Add to dashboard Cite

Background: Exposure to air pollution (gaseous pollutants and/or particulate matter) has been associated with the incidence, prevalence, and mortality of type 1 diabetes (T1D). Purpose: To examine the quantitative relationship between air pollutant emissions and the incidence of T1D. Methods: We examined the association between the incidence of T1D and type 2 diabetes (T2D) in 2017 as well as that of T1D in patients younger than 15 years in 2016 with "emissions of air polluting substances from stationary and mobile sources by regions of the Russian Federation in 2016" as reported by the Federal Diabetes Register of Russia downloaded from the Russian government website, "http://www.mnr.gov.ru/docs/gosudarstvennye_doklady/o_sostoyanii_i_ob_okhrane_okruzha yushchey_sredy_rossiyskoy_federatsii/." Results: The incidence of T1D across all ages in each region of the Russian Federation correlated with the total air pollutants emitted in the region each year (r = 0.278, p = 0.013). The incidence of T2D was also correlated with the amount of air pollutants (r = 0.234, p = 0.037) and the incidence of T1D (r = 0.600, p < 0.001) in each country. Similarly, the incidence of T1D in patients younger than 15 years correlated with the total air pollutants emitted each year in each region (r = 0.300, p = 0.011). Conclusion: The quantitative relationship between the total air pollutants emitted and the incidence of T1D and T2D in the Russian Federation suggests that air pollution contributes to the development of T1D and T2D.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation between total air pollutant emissions and incidence of type 1 diabetes in the Russian Federation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Study descriptions, design, approach to exposure assessment, and results are summarized for each of the 34 studies in Table 2. Of the 34 studies, nine (27%) were conducted in the US (Hathout et al 2006;Chen et al 2016;White et al 2016;Miller et al 2016a;Jerrett et al 2017;Hernandez et al 2018;Li et al 2018;Toledo-Corral et al 2018;Starling et al 2020), nine in China (Dong et al 2014;Li et al 2015;Song et al 2018;Yang et al 2018aYang et al , 2018bYang et al , 2019aYang et al , 2019bLi et al 2019;Zhang et al 2019), six in Europe (Malmqvist et al 2015;Di Ciaula 2016;Tamayo et al 2016;Lanzinger et al 2018;Orioli et al 2018;Renzi et al 2018), three in Taiwan (Chuang et al 2010(Chuang et al , 2011Chin et al 2018), three in South Korea (Kim and Hong 2012;Kim et al 2018;Shin et al 2019), two in Canada (To et al 2015;Elten et al 2020), one in Chile (Dales et al 2012), and one in Malaysia (Wong et al 2020).…”

Section: Human Studiesmentioning

confidence: 99%

“…Seven studies evaluated associations between ozone exposure and T1D (Table 2). Some studies were specific to T1D, while other study investigators assumed that all pediatric cases were T1D based on age (Elten et al 2020).…”

Section: Studies Of T1dmentioning

confidence: 99%

Does ozone inhalation cause adverse metabolic effects in humans? A systematic review

LaKind

Burns²,

Pottenger³

et al. 2021

Critical Reviews in Toxicology

View full text Add to dashboard Cite

We utilized a practical, transparent approach for systematically reviewing a chemical-specific evidence base. This approach was used for a case study of ozone inhalation exposure and adverse metabolic effects (overweight/obesity, Type 1 diabetes [T1D], Type 2 diabetes [T2D], and metabolic syndrome). We followed the basic principles of systematic review. Studies were defined as "Suitable" or "Supplemental." The evidence for Suitable studies was characterized as strong or weak. An overall causality judgment for each outcome was then determined as either causal, suggestive, insufficient, or not likely. Fifteen epidemiologic and 33 toxicologic studies were Suitable for evidence synthesis. The strength of the human evidence was weak for all outcomes. The toxicologic evidence was weak for all outcomes except two: body weight, and impaired glucose tolerance/homeostasis and fasting/baseline hyperglycemia. The combined epidemiologic and toxicologic evidence was categorized as weak for overweight/obesity, T1D, and metabolic syndrome,. The association between ozone exposure and T2D was determined to be insufficient or suggestive. The streamlined approach described in this paper is transparent and focuses on key elements. As systematic review guidelines are becoming increasingly complex, it is worth exploring the extent to which related health outcomes should be combined or kept distinct, and the merits of focusing on critical elements to select studies suitable for causal inference. We recommend that systematic review results be used to target discussions around specific research needs for advancing causal determinations.

show abstract

“…7) Moreover, Elten et al showed that ozone exposure during the first trimester of pregnancy was associated with an increased incidence of T1D at an early age. 8)…”

mentioning

confidence: 99%

“…An environmental-wide association study performed in England revealed that several air pollutants, including PM 10 , NO 2 , nitrogen oxides, and carbon monoxide, were associated with the risk of T1D in children [ 7 ]. Moreover, Elten et al [ 8 ] showed that ozone exposure during the first trimester of pregnancy was associated with an increased incidence of T1D at an early age.…”

mentioning

confidence: 99%

Ambient air pollution and pediatric diabetes

Kim

2021

Clin Exp Pediatr

View full text Add to dashboard Cite

show abstract

Ambient air pollution and incidence of early-onset paediatric type 1 diabetes: A retrospective population-based cohort study

Cited by 30 publications

References 57 publications

Correlation between total air pollutant emissions and incidence of type 1 diabetes in the Russian Federation

Correlation between total air pollutant emissions and incidence of type 1 diabetes in the Russian Federation

Does ozone inhalation cause adverse metabolic effects in humans? A systematic review

Ambient air pollution and pediatric diabetes

Contact Info

Product

Resources

About