Ambient air pollution and inflammatory effects in a Canadian pregnancy cohort

Gogna, Priyanka; Villeneuve, Paul J.; Kumarathasan, Premkumari; Johnson, Markey; Lanphear, Bruce P.; Shutt, Robin; Arbuckle, Tye E.; Borghese, Michael M.

doi:10.1097/ee9.0000000000000168

Cited by 12 publications

(17 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47 Daily mean concentrations for all ambient air pollutants were averaged to represent exposures 14 days before the collection of blood samples for CRP measurement. In our previous work, the specific 14-day exposure window had the strongest and most consistent association with CRP levels, 46 which is consistent with a previous review paper. 51…”

Section: Study Population and Designsupporting

confidence: 90%

“…In previous investigations of this cohort, we showed that PM 2.5 exposure during late pregnancy was positively associated with CRP concentrations over 14-day and 30-day exposure windows 46 and that exposures to PM 2.5 and NO 2 during pregnancy were associated with reduced birthweight. 47 The primary objective of this study is to extend the previous work on biomarkers, by investigating the independent and combined effects of PM 2.5 , NO 2 , and O 3 , on CRP concentrations.…”

Section: Introductionmentioning

confidence: 49%

See 1 more Smart Citation

A cohort study of the multipollutant effects of PM2.5, NO2, and O3 on C-reactive protein levels during pregnancy

Gogna,

Borghese,

Villeneuve

et al. 2024

Environmental Epidemiology

Self Cite

View full text Add to dashboard Cite

Background: PM2.5, NO2, and O3 contribute to the development of adverse pregnancy complications. While studies have investigated the independent effects of these exposures, literature on their combined effects is limited. Our objective was to study the multipollutant effects of PM2.5, NO2, and O3 on maternal systemic C-reactive protein (CRP) levels. Methods: We used data from 1170 pregnant women enrolled in the Maternal-Infant Research on Environmental Chemicals Study (MIREC) study in Canada. Air pollution exposures were assigned to each participant based on residential location. CRP was measured in third-trimester blood samples. We fit multipollutant linear regression models and evaluated the effects of air pollutant mixtures (14-day averages) using repeated-holdout Weighted Quantile Sum (WQS) regression and by calculating the Air Quality Health Index (AQHI). Results: In multipollutant models adjusting for NO2, O3, and green space, each interquartile range (IQR) increase in 14-day average PM2.5 (IQR: 6.9 µg/m3) was associated with 27.1% (95% confidence interval [CI] = 6.2, 50.7) higher CRP. In air pollution mixture models adjusting for green space, each IQR increase in AQHI was associated with 37.7% (95% CI = 13.9, 66.5) higher CRP; and an IQR increase in the WQS index was associated with 78.6% (95% CI = 29.7, 146.0) higher CRP. Conclusion: PM2.5 has the strongest relationship of the individual pollutants examined with maternal blood CRP concentrations. Mixtures incorporating all three pollutants, assessed using the AQHI and WQS index, showed stronger relationships with CRP compared with individual pollutants and illustrate the importance of conducting multipollutant analyses.

show abstract

Section: Study Population and Designsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 49%

A cohort study of the multipollutant effects of PM2.5, NO2, and O3 on C-reactive protein levels during pregnancy

Gogna,

Borghese,

Villeneuve

et al. 2024

Environmental Epidemiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Studies have found that PM 2.5 can inhibit the gene expression and activity of endogenous antioxidant enzymes (48), activate the body's oxidative stress response, and promote dysfunction in multiple organs and systems (49,50). Previous studies have reported that increased traffic-related PM 2.5 concentrations are associated with altered responses to inflammatory markers (51). Animal experiments have found that artificial PM 2.5 exposure can induce increased levels of interleukin (IL)-1, IL-6 and tumor necrosis factor α (TNFα) in rats, thereby increasing the risk of nasal lesions (52).…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between particulate matter 2.5 and hypothyroidism: A two-sample Mendelian randomization study

Zhang

Liu²,

Wang³

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

BackgroundEpidemiological surveys have found that particulate matter 2.5 (PM2.5) plays an important role in hypothyroidism. However, due to the methodological limitations of traditional observational studies, it is difficult to make causal inferences. In the present study, we assessed the causal association between PM2.5 concentrations and risk of hypothyroidism using two-sample Mendelian randomization (TSMR).MethodsWe performed TSMR by using aggregated data from genome-wide association studies (GWAS) on the IEU Open GWAS database. We identified seven single nucleotide polymorphisms (SNPs) associated with PM2.5 concentrations as instrumental variables (IVs). We used inverse-variance weighting (IVW) as the main analytical method, and we selected MR-Egger, weighted median, simple model, and weighted model methods for quality control.ResultsMR analysis showed that PM2.5 has a positive effect on the risk of hypothyroidism: An increase of 1 standard deviation (SD) in PM2.5 concentrations increases the risk of hypothyroidism by ~10.0% (odds ratio 1.10, 95% confidence interval 1.06–1.13, P = 2.93E-08, by IVW analysis); there was no heterogeneity or pleiotropy in the results.ConclusionIn conclusion, increased PM2.5 concentrations are associated with an increased risk of hypothyroidism. This study provides evidence of a causal relationship between PM2.5 and the risk of hypothyroidism, so air pollution control may have important implications for the prevention of hypothyroidism.

show abstract

“…Only limited human studies have demonstrated a link between prenatal metal exposure and an increase in maternal inflammatory markers. [45][46][47][48][49] Notably, Farzan et al 45 observed a relationship between prenatal arsenic exposure and an increase in cord blood of ICAM1 and VCAM1 in the New Hampshire Birth Cohort (n = 563). Similarly, in the present study, we observed significant positive associations between Ni and CRP and between Pb and VCAM (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico

Kim

Cathey

Watkins

et al. 2022

Environmental Epidemiology

View full text Add to dashboard Cite

Background: Studies have revealed a link between aberrant levels of maternal C-reactive protein (CRP) and cell adhesion molecules (CAMs) with adverse birth outcomes. Some epidemiologic studies have indicated that long-term metal exposures can modulate the levels of CRP and CAMs, but the associations between prenatal metal exposures and the levels of CRP and CAMs have yet to be studied more extensively. In this study, we assessed associations between maternal blood metal levels and CRP/CAMs among 617 pregnant women in the Puerto Rico PROTECT birth cohort. Methods: Blood samples were collected from participants at 16–20 (visit 1) and 24–28 (visit 3) weeks gestation. We measured concentrations of 11 metals using inductively coupled plasma mass spectrometry (ICP-MS). From the blood samples, CRP and CAMs intercellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) were also quantified using a customized Luminex assay. Linear-mixed effects models (LMEs) were used to regress CRP and CAMs on metals and included random intercepts for study participants to account for correlated repeated outcome measures. Fetal sex and visit effects were estimated using interaction terms between metal exposure variables and fetal sex, as well as visit indicators, respectively. Results: We observed significant positive associations between nickel and CRP (Δ: 7.04, 95% CI = 0.75, 13.73) and between lead and VCAM (Δ: 4.57, 95% CI = 1.36, 7.89). The positive associations were mainly driven by mothers carrying male fetuses. We also observed various visit-specific associations. The significant associations between metals and CRP were predominantly driven by visit 3; however, the significant associations between metals and VCAM were mainly driven by visit 1. Conclusion: Certain maternal blood metal levels were significantly associated with CRP and CAMs and most of these associations were differentially driven by fetal sex, as well as by timing in pregnancy. Future studies should further explore metal-CRP/CAMs associations for a better understanding of the underlying mechanism of metal-induced adverse birth outcomes.

show abstract

Ambient air pollution and inflammatory effects in a Canadian pregnancy cohort

Abstract: Supplemental Digital Content is available in the text.

Cited by 12 publications

References 70 publications

A cohort study of the multipollutant effects of PM2.5, NO2, and O3 on C-reactive protein levels during pregnancy

A cohort study of the multipollutant effects of PM2.5, NO2, and O3 on C-reactive protein levels during pregnancy

Causal relationship between particulate matter 2.5 and hypothyroidism: A two-sample Mendelian randomization study

Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico

Contact Info

Product

Resources

About