Ambient air pollution and suicide in Tokyo, 2001–2011

Ng, Chris Fook Sheng; Stickley, Andrew; Konishi, Shoko; Watanabe, Chiho

doi:10.1016/j.jad.2016.05.006

Cited by 95 publications

(45 citation statements)

References 73 publications

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“…Similarly, a recent study in Tokyo found the effect of NO 2 on suicide among those aged under 30 years was significantly greater than those aged 30–60 years 15. In another study in Beijing, positive and statistically significant associations between air pollution and schizophrenia admissions were only found among patients younger than 45 years old 5.…”

Section: Discussionmentioning

confidence: 80%

Ambient concentrations of NO₂ and hospital admissions for schizophrenia

Bai

Zhang

et al. 2018

Occup Environ Med

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ObjectivesSchizophrenia is a chronic and severe mental disorder affecting more than 21 million people worldwide. Short-term exposure to nitrogen dioxide (NO2) has been associated with hospital admissions (HAs) for mental disorders, but no study has evaluated the specific association of NO2 and schizophrenia. Additionally, the shape of the concentration–response (C–R) curve has not yet been assessed at present. This study aims to investigate the relationship between short-term exposure to NO2 and HAs for schizophrenia in Hefei, from 2014 to 2016. We also attempt to explore the C–R and the underlying effect modifiers of the association.MethodsDaily number of HAs for schizophrenia was derived from the computerised medical record system of Anhui Mental Health Center. We used a time-series Poisson generalised linear regression combined with distributed lag non-linear models to model the NO2–schizophrenia relationship.ResultsA total of 11 373 HAs were identified during the study period. An increase in levels of NO2 was significantly associated with elevated schizophrenia HAs. The estimated relative risk per IQR increase in NO2 at lag 01 was 1.10 (95% CI 1.01 to 1.18). Greater association was observed in young patients (relative risk: 1.11, 95% CI 1.02 to 1.19). The modelled C–R curves of the NO2–schizophrenia relationship suggested possible threshold effects of NO2 for all ages combined, young patients, men and both seasons.ConclusionsShort-term exposure to NO2 may be associated with increased schizophrenia HAs. Findings indicated potential threshold effects of NO2, which has important implications for health-based risk assessments.

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Section: Discussionmentioning

confidence: 80%

Ambient concentrations of NO₂ and hospital admissions for schizophrenia

Bai

Zhang

et al. 2018

Occup Environ Med

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“…Increased O 3 was associated with increased risk for suicide in three out of four studies (55,57,61). SO 2 increase demonstrated an increased risk for suicide in four out of five studies (28,55,56,60). An increase in CO demonstrated a positive association with suicide risk in one out of three studies and a negative association in one of three studies (28,55).…”

Section: Air Pollutantsmentioning

confidence: 81%

“…age group and suicide method). Increased NO 2 showed increase risk for suicide in four out of five studies (28,56,59,60). Increased O 3 was associated with increased risk for suicide in three out of four studies (55,57,61).…”

Section: Air Pollutantsmentioning

confidence: 83%

“…The effects of air pollution and aeroallergens on suicidality have been scarcely investigated; however, there is initial evidence suggesting a positive correlation between air pollution, aeroallergens and suicidality (53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66). Herein, the overarching aim is to provide a succinct review of the available literature on changes in air pollution, aeroallergens and their relationships to suicidal behavior, exploring potential mechanisms by which air pollution may influence suicide rates.…”

Section: Aeroallergensmentioning

confidence: 99%

“…In particular, Bakian et al (59) demonstrated that a single day of exposure to PM 2.5 and NO 2 on 2 days prior to suicide conferred an increased risk of suicidality [odd ratio (OR) = 1.05, 95% confidence interval (CI): 1.01, 1.10; OR = 1.13, 95% CI: 1.01, 1.27]. A trend exists in that increased air pollution lag days show decreased suicide risk (56,60). However, the long-term impact of exposure to air pollution has yet to be fully elucidated and may have greater cumulative effects when combined with other risk factors for suicide.…”

Section: Durationmentioning

confidence: 99%

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Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms

Ragguett

Danielle

Subramaniapillai

et al. 2017

Reviews on Environmental Health

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Objective: Risk factors for suicide can be broadly categorized as sociodemographic, clinical and treatment. There is interest in environmental risk and protection factors for suicide. Emerging evidence suggests a link between environmental factors in the form of air pollution and aeroallergens in relation to suicidality. Methods: Herein, we conducted a systematic review of 15 articles which have met inclusion criteria on the aforementioned effects. Results: The majority of the reviewed articles reported an increased suicide risk alongside increased air pollutants or aeroallergens (i.e. pollen) increase; however, not all environmental factors were explored equally. In specific, studies that were delimited to evaluating particulate matter (PM) reported a consistent association with suicidality. We also provide a brief description of putative mechanisms (e.g. inflammation and neurotransmitter dysregulation) that may mediate the association between air pollution, aeroallergens and suicidality. Conclusion:Available evidence suggests that exposure to harmful air quality may be associated with suicidality. There are significant public health implications which are amplified in regions and countries with greater levels of air pollution and aeroallergens. In addition, those with atopic sensitivity may represent a specific subgroup that is at risk.

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