Ambient air pollution in relation to diabetes and glucose-homoeostasis markers in China: a cross-sectional study with findings from the 33 Communities Chinese Health Study

Yang, Bo‐Yi; Qian, Zhengmin; Li, Shanshan; Chen, Gongbo; Bloom, Michael S.; Elliott, Michael; Syberg, Kevin; Heinrich, Joachim; Markevych, Iana; Wang, Si-Quan; Chen, Da; Ma, Huimin; Chen, Duo-Hong; Liu, Yimin; Komppula, Mika; Leskinen, Ari; Liu, Kangkang; Zeng, Xiao‐Wen; Hu, Liwen; Lee, Hyewon; Dong, Guang‐Hui

doi:10.1016/s2542-5196(18)30001-9

Cited by 185 publications

(111 citation statements)

References 38 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…Individuals with T2DM have elevated cytokine levels in blood compared to people without diabetes and there is mounting evidence that supports that diabetes and particulate air pollution are associated with inflammatory dysregulation [22,93,94]. In addition, there is evidence that increased exposure to PM is significantly associated with increased fasting blood glucose (a biomarker for diabetes) in humans [73,95]. Whilst epidemiological evidence suggests that PM exposure is a risk factor for T2DM development, further research is required to better understand the cellular and molecular events underlying this as few studies have investigated the mechanism of toxicity, to date.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Dimakakou

Johnston

Streftaris

et al. 2018

IJERPH

View full text Add to dashboard Cite

It has been hypothesised that environmental air pollution, especially airborne particles, is a risk factor for type 2 diabetes mellitus (T2DM) and neurodegenerative conditions. However, epidemiological evidence is inconsistent and has not been previously evaluated as part of a systematic review. Our objectives were to carry out a systematic review of the epidemiological evidence on the association between long-term exposure to ambient air pollution and T2DM and neurodegenerative diseases in adults and to identify if workplace exposures to particles are associated with an increased risk of T2DM and neurodegenerative diseases. Assessment of the quality of the evidence was carried out using the GRADE system, which considers the quality of the studies, consistency, directness, effect size, and publication bias. Available evidence indicates a consistent positive association between ambient air pollution and both T2DM and neurodegeneration risk, such as dementia and a general decline in cognition. However, corresponding evidence for workplace exposures are lacking. Further research is required to identify the link and mechanisms associated with particulate exposure and disease pathogenesis and to investigate the risks in occupational populations. Additional steps are needed to reduce air pollution levels and possibly also in the workplace environment to decrease the incidence of T2DM and cognitive decline.

show abstract

Section: Discussionmentioning

confidence: 99%

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Dimakakou

Johnston

Streftaris

et al. 2018

IJERPH

View full text Add to dashboard Cite

show abstract

“…45 For the SO 2 , studies also showed similar mechanisms, such as inflammation 46 and dysfunction of pancreatic β-cells. 47 It has been argued that NO 2 and NO x can lead similar inflammation responses to those of particulate matter and O 3 . 48 The strengths of our study included the adjustment for multiple confounders including geographic, sex, BMI, smoking, alcohol consumption, socioeconomic status, and age variables that affected the individual studies, but were reduced by our study design.…”

Section: Discussionmentioning

confidence: 99%

Air pollution and gestational diabetes mellitus: evidence from cohort studies

Tang

Zhou

Luo

et al. 2020

BMJ Open Diab Res Care

View full text Add to dashboard Cite

Exposure to different air pollutants has been linked to type 2 diabetes mellitus, but the evidence for the association between air pollutants and gestational diabetes mellitus (GDM) has not been systematically evaluated. We systematically retrieved relevant studies from PubMed, Embase, and the Web of Science, and performed stratified analyses and regression analyses. Thirteen studies were analyzed, comprising 1 547 154 individuals from nine retrospective studies, three prospective studies, and one case–control study. Increased exposure to particulate matter ≤2.5 µm in diameter (PM2.5) was not associated with the increased risk of GDM (adjusted OR 1.03, 95% CI 0.99 to 1.06). However, subgroup analysis showed positive correlation of PM2.5 exposure in the second trimester with an increased risk of GDM (combined OR 1.07, 95% CI 1.00 to 1.13). Among pollutants other than PM2.5, significant association between GDM and nitrogen dioxide (NO2) (OR 1.05, 95% CI 1.01 to 1.10), nitrogen oxide (NOx) (OR 1.03, 95% CI 1.01 to 1.05), and sulfur dioxide (SO2) (OR 1.09, 95% CI 1.03 to 1.15) was noted. There was no significant association between exposure to black carbon or ozone or carbon monoxide or particulate matter ≤10 µm in diameter and GDM. Thus, systematic review of existing evidence demonstrated association of exposure to NO2, NOx, and SO2, and the second trimester exposure of PM2.5 with the increased risk of GDM. Caution may be exercised while deriving conclusions from existing evidence base because of the limited number and the observational nature of studies.

show abstract

“…Air pollution has become one of the most urgent health issues worldwide, causing 6.5 million premature deaths in 2015 11 . Additionally, air pollution has emerged as an unexpected risk factor for diabetes in many epidemiological 1–6 and rodent studies 12,13 . This association even occurs at air pollution levels well below those labelled as safe by the World Health Organization 14 .…”

Section: Figmentioning

confidence: 99%

“… Air pollution has emerged as an unexpected risk factor for diabetes 1–6 . The mechanisms linking air pollution and diabetes remain, however, unknown.…”

mentioning

confidence: 99%

Air pollution mediates diabetes by disrupting gut innate mucosal immunity

Bosch

Rohm

AlAsfoor

et al. 2019

Preprint

View full text Add to dashboard Cite

15Air pollution has emerged as an unexpected risk factor for diabetes 1-6 . The mechanisms 16 linking air pollution and diabetes remain, however, unknown. It has been postulated 17 that lung exposure mediates diabetes via systemic inflammation and insulin resistance 7-9 . 18 By contrast, gut exposure to pollutants has received little attention, even though a large 19 proportion of air pollution particles are swallowed after mucociliary clearance from the 20 upper airways 10 . Here, we identified intestinal macrophages as key mediators linking air 21 pollutants with impaired beta-cell function. Upon oral exposure to air pollution, 22 intestinal macrophages up-regulated inflammatory-and interferon-response pathways, 23 which disrupted their normal differentiation towards an anti-inflammatory/resident 24 phenotype. The resulting pro-inflammatory milieu in the gut impaired beta-cell identity 25

show abstract

Ambient air pollution in relation to diabetes and glucose-homoeostasis markers in China: a cross-sectional study with findings from the 33 Communities Chinese Health Study

Cited by 185 publications

References 38 publications

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Air pollution and gestational diabetes mellitus: evidence from cohort studies

Air pollution mediates diabetes by disrupting gut innate mucosal immunity

Contact Info

Product

Resources

About