2020
DOI: 10.3390/toxics8030052
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Ambient Exposure to Agricultural Pesticides during Pregnancy and Risk of Cerebral Palsy: A Population-Based Study in California

Abstract: Cerebral palsy (CP) is the most common neuro-motor disability in young children. Disruptions of maternal hormone function during pregnancy have been linked to CP risk. We investigated whether prenatal exposure to pesticide compounds with endocrine-disrupting action affect CP risk. We conducted a case-control study of 3905 CP cases and 39,377 controls born between 1998 and 2010 in California to mothers who lived in proximity (within 2 km) to any agricultural pesticide application recorded in the California Pest… Show more

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Cited by 13 publications
(10 citation statements)
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“…These properties provide an opportunity to improve existing air pollution monitoring capabilities. It may also provide avenues to new air monitoring applications for population exposure to air pollutants [86,87].…”
Section: Discussionmentioning
confidence: 99%
“…These properties provide an opportunity to improve existing air pollution monitoring capabilities. It may also provide avenues to new air monitoring applications for population exposure to air pollutants [86,87].…”
Section: Discussionmentioning
confidence: 99%
“…The DDS provides service and support to residents in California who have developmental disabilities or conditions (including CP) through 21 statewide regional centers . We used a probabilistic linkage algorithm to match the DDS records and the California birth records using parental and child’s identifying information (first and last name, date of birth, sex of child) . CP cases registered in the DDS with a birthplace other than California were not eligible for the study.…”
Section: Methodsmentioning
confidence: 99%
“…22 We used a probabilistic linkage algorithm to match the DDS records and the California birth records using parental and child’s identifying information (first and last name, date of birth, sex of child). 18 , 23 , 24 CP cases registered in the DDS with a birthplace other than California were not eligible for the study. Overall, we identified a total of 4942 CP cases (linkage rate of 93%), with nonlinkages mainly due to missing identifying information.…”
Section: Methodsmentioning
confidence: 99%
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“…A variety of pesticides are prohibited because they are not biodegradable and impact human health [ 162 ]. Chemical pesticides were also identified as causing birth defects in children and cancer [ 163 , 164 ]. The contamination of organochloride pesticides in food products and water are also concerning, due to the danger in long-range transport, bioaccumulation in human and animal tissue, and biomagnification in food chains [ 165 ].…”
Section: Nanotechnology In Food Monitoringmentioning
confidence: 99%