Ambient ozone and fine particulate matter exposures and autism spectrum disorder in metropolitan Cincinnati, Ohio

Kaufman, John A.; Wright, J. Michael; Rice, Glenn; Connolly, Natalia; Bowers, Katherine; Anixt, Julia S.

doi:10.1016/j.envres.2019.01.013

Cited by 39 publications

(34 citation statements)

References 69 publications

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“…Particulate matter (PM), and especially its fine fraction (PM 2.5 ), existing in the atmosphere is considered to cause severe and different toxic effects on humans, including respiratory (Kowalska et al, 2019) and cardiovascular diseases (Du et al, 2019), nephrotoxicity (Hsu et al, 2005), diabetes (Lao et al, 2019), fetal distress in pregnant women (Liu et al, 2019), allergy (Dedele et al, 2019), autism (Kaufman et al, 2019), decreased fertility (Xia et al, 2019), and cancer (Santibáñez-Andrade et al, 2017). Eye irritation, dry throat, runny nose, sneezing, cough, tiredness, irritability, difficulty concentrating, headache, dizziness, and skin irritation are other less serious, indeed annoying side effects of human exposure to PM (Nezis et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Metal Ion Release from Fine Particulate Matter Sampled in the Po Valley to an Aqueous Solution Mimicking Fog Water: Kinetics and Solubility

Marco

Tapparo

Badocco

et al. 2020

Aerosol Air Qual. Res.

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Metals are among the key aerosol components exerting adverse health effects. Their toxic properties may vary depending on their chemical form and solubility, which can be affected by aqueous processing during aerosol atmospheric lifetime. In this work, fine particulate matter (PM 2.5) was collected in the city centre of Padua in the Po Valley (Italy), during a winter campaign. Part of the sampling filters were used to measure the kinetics by which metal ions and other elements can leach from PM 2.5 to an aqueous solution mimicking fog water in the winter in temperate climate regions (pH 4.7, 5°C). The leaching process was interpreted by a first order kinetics, and the fitting of the experimental data allowed to obtain the leaching kinetic constants and the equilibrium concentrations (i.e., at infinite time) for all elements. The remaining filter parts were mineralised, through two subsequent extraction steps, and the extracts were analysed by ICP-MS to gain the total elemental content of PM for a large number of elements. We found that elements can leach from PM with half times generally between 10-40 minutes, which is a timescale compatible with atmospheric aqueous processing during fog events. For instance, aluminium(III) in PM 2.5 dissolved with an average k = 0.0185 min-1 , and t 1/2 = 37.5 min. Nevertheless, a fraction of each element was immediately solubilised after contact with the extraction solution suggesting that metal ion solubilisation may already had started during particle lifetime in the atmosphere.

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Section: Introductionmentioning

confidence: 99%

Metal Ion Release from Fine Particulate Matter Sampled in the Po Valley to an Aqueous Solution Mimicking Fog Water: Kinetics and Solubility

Marco

Tapparo

Badocco

et al. 2020

Aerosol Air Qual. Res.

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“…The review found evidence for associations between prenatal exposure to PM 2:5 and ASD (Lam et al 2016). Additional studies have been published since this review that have found positive associations between prenatal and/or early life PM 2:5 exposure and ASD (Kaufman et al 2019;Jo et al 2019;McGuinn et al 2020).…”

Section: Discussionmentioning

confidence: 81%

“…2016 ). Additional studies have been published since this review that have found positive associations between prenatal and/or early life

exposure and ASD ( Kaufman et al. 2019 ; Jo et al.…”

Section: Discussionmentioning

confidence: 99%

Co-Benefits to Children’s Health of the U.S. Regional Greenhouse Gas Initiative

Perera

Cooley

Berberian

et al. 2020

Environ Health Perspect

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BACKGROUND: While various policies have been implemented globally to mitigate climate change and reduce exposure to toxic air pollutants, policy assessments have considered few if any of the benefits to children. OBJECTIVE: To comprehensively assess the co-benefits of climate change mitigation to children, we expanded the suite of adverse health outcomes in the U.S. Environmental Protection Agency's Benefits Mapping and Analysis Program (BenMAP) to include additional outcomes associated with prenatal and childhood exposure to ambient fine particulate matter (PM 2:5). We applied this newly expanded program to an assessment of the U.S. Regional Greenhouse Gas Initiative (RGGI), the United States' first regional market-based regulatory program designed to reduce greenhouse gas emissions from the electric power sector within the Northeast. METHODS: We used calculated changes in ambient PM 2:5 concentrations for the period 2009-2014, with newly incorporated concentration-response (C-R) functions to quantify changes in the incidence of preterm birth (PTB), term low birth weight (TLBW), autism spectrum disorder (ASD), and asthma. These outcomes are causally or likely to be causally related to PM 2:5 exposure. Cost per case estimates were incorporated to monetize those changes in incidence. RESULTS: The estimated avoided cases of adverse child health outcomes included 537 asthma cases, 112 preterm births, 98 cases of ASD, and 56 cases of TLBW, with an associated avoided cost estimate ranging from $191 to $350 million. In a previous analysis of health benefits of RGGI, the only benefits accruing to children were limited to prevented cases of infant mortality and respiratory illnesses, with a monetized impact of $8.1 million-only 2-4% of the new results attributable to RGGI. CONCLUSION: The results of this innovative analysis indicate that RGGI has provided substantial child health benefits beyond those initially considered. Moreover, those health benefits had significant estimated economic value.

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“…We found 12 studies (9 case-control and 3 cohort studies) investigating the association between the risk of ASD onset and maternal exposure to PM (PM 2.5 and PM 10 ) during pregnancy and in the first years of the child's life and the risk ASD onset (Table 1). The case-control studies showed a positive association between PM exposure (especially PM 2.5 ) during pregnancy or early life and ASD [23][24][25][26][27][28][29][30][31], while the cohort studies demonstrated a less significant relationship.…”

Section: Association Between Pm and Asdmentioning

confidence: 99%

Early-Life Exposure to Environmental Air Pollution and Autism Spectrum Disorder: A Review of Available Evidence

Imbriani

Panìco

Grassi

et al. 2021

IJERPH

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The number of children diagnosed with Autism Spectrum Disorder (ASD) has rapidly increased globally. Genetic and environmental factors both contribute to the development of ASD. Several studies showed linkage between prenatal, early postnatal air pollution exposure and the risk of developing ASD. We reviewed the available literature concerning the relationship between early-life exposure to air pollutants and ASD onset in childhood. We searched on Medline and Scopus for cohort or case-control studies published in English from 1977 to 2020. A total of 20 articles were selected for the review. We found a strong association between maternal exposure to particulate matter (PM) during pregnancy or in the first years of the children’s life and the risk of the ASD. This association was found to be stronger with PM2.5 and less evident with the other pollutants. Current evidence suggest that pregnancy is the period in which exposure to environmental pollutants seems to be most impactful concerning the onset of ASD in children. Air pollution should be considered among the emerging risk factors for ASD. Further epidemiological and toxicological studies should address molecular pathways involved in the development of ASD and determine specific cause–effect associations.

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Ambient ozone and fine particulate matter exposures and autism spectrum disorder in metropolitan Cincinnati, Ohio

Cited by 39 publications

References 69 publications

Metal Ion Release from Fine Particulate Matter Sampled in the Po Valley to an Aqueous Solution Mimicking Fog Water: Kinetics and Solubility

Metal Ion Release from Fine Particulate Matter Sampled in the Po Valley to an Aqueous Solution Mimicking Fog Water: Kinetics and Solubility

Co-Benefits to Children’s Health of the U.S. Regional Greenhouse Gas Initiative

Early-Life Exposure to Environmental Air Pollution and Autism Spectrum Disorder: A Review of Available Evidence

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