Previous studies have focused on task/ambient illumination for visual effects and eye illumination for non-visual effects. In this context, eye illumination within the non-visual realm was defined as vertical non-visual eye illuminance. Considering the functional specificity of central vision and peripheral vision, this study aims to explore whether the distribution of eye illuminance in the horizontal field of view (FOV) affects human performance in home paper-based learning settings. In this study, a within-subject design was used to investigate the effects of eye illuminance distribution on mental perception, task performance, and physiological health while maintaining constant task illuminance and correlated color temperature (CCT). The findings revealed that eye illuminance and its distribution in the horizontal FOV had complex effects on visual fatigue, Landolt ring performance, heart rate variability, and luminous environment appraisal. A relatively optimal lighting configuration was suggested—Scene 4, which was characterized by an eye illuminance level in central FOV of 186 lx and an “m” shaped eye illuminance distribution pattern. This indicates the importance of considering eye illuminance distribution in the horizontal FOV, rather than solely focusing on vertical eye illuminance.