Museums have an important role in transmitting information and providing scientific and historical experiences to visitors. As published in the 2020 report by the International Council of Museums (ICOM), the COVID-19 pandemic has disrupted the activities of museums around the world, affecting the country economically and culturally. Accordingly, the design of movement paths must be reconsidered to adapt to the precautionary measures for the COVID-19 virus. The research paper is based on a theoretical study followed by an analytical study of a number of international and regional museums that used specific precautionary measures to limit the spread of the COVID-19 virus. The results of these studies helped in an applied study using syntax in space to improve circulation in the National Museum of Egyptian Civilization. The study highlighted the ability of syntax techniques in defining the problem, making decisions to design circulation within the exhibition halls of the museum, and providing recommendations to improve circulation within the National Museum of Egyptian Civilization in times of epidemic crises.