Ambiguity of the Brenner-Hall Model

Harrison, Greg J.; Balcer‐Kubiczek, Elizabeth K.

doi:10.1080/09553009214550711

International Journal of Radiation Biology

1992

DOI: 10.1080/09553009214550711

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Ambiguity of the Brenner-Hall Model

Greg J. Harrison

Elizabeth K. Balcer‐Kubiczek

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Cited by 9 publications

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“…Hypotheses and proposed models for the effect have not yet led to a consensus (Hill et al . 1984, Barendsen 1984, Rossie and Kellerer 1986, Burch and Chesters 1986, Booz and Feinendegen 1988, Sykes and Watt 1989, Elkind 1991, Brenner and Hall 1991, Harrison and Balcer-Kubiczek 1991 . The proposals made seek answers to the mechanisms involved, and to fundamental questions such as : is damage to the DNA a prerequisite for subsequent transformation?…”

mentioning

confidence: 99%

Comment on Mechanism of Radiation Effects with Special Reference to Transformation

Watt

1992

International Journal of Radiation Biology

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mentioning

confidence: 99%

Comment on Mechanism of Radiation Effects with Special Reference to Transformation

Watt

1992

International Journal of Radiation Biology

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Radiocarcinogenesis in vitro: «Inverse dose-rate effect»

et al. 1992

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ricevuto il 15 Giugno 1992; approvato il 24 Luglio 1992)Summary. --There is substantial experimental evidence that protracted exposure to high-LET radiation can have a greater effect than single exposure in inducing cell transformation, the so-called ~4nverse dose-rate effect-. The magnitude of this enhancement is due to the complex interplay between dose, dose rate and radiation quality. We have developed a model that explains the complex trend of the experimental results. This model is based on the assumption that there is a brief period of high sensitivity to transformation in the cell cycle as proposed in the literature and takes into account the saturation observed at high doses in the dose-effect curves. Specific equations are reported for acute, protracted and fractionated irradiation. Findings with C3H10T1/2 cells were analised in the light of this model. Assuming best fitted parameters of the model obtained from acute-h'radi~tion data, transformation frequencies due to protracted or fractionated exposure were predicted and compared with experimental findings on fission and monoenergetic neutrons and on charged particles of LET between 20 and 150 keV/,~m. The model's predictions were found to be closely consistent with the available experimental data.

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A diversity of responses displayed by a stochastic model of radiation carcinogenesis allowing for cell death

Yakovlev

Polig

1996

Mathematical Biosciences

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Ambiguity of the Brenner-Hall Model

Cited by 9 publications

References 9 publications

Comment on Mechanism of Radiation Effects with Special Reference to Transformation

Comment on Mechanism of Radiation Effects with Special Reference to Transformation

Radiocarcinogenesis in vitro: «Inverse dose-rate effect»

A diversity of responses displayed by a stochastic model of radiation carcinogenesis allowing for cell death

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