Ambulant health care utilisation among children of childhood cancer survivors in Germany

Schuster, Theresa; Korte, Elisabeth; Schilling, Ralph; Hölling, Heike; Balcerek, Magdalena; Borgmann‐Staudt, Anja

doi:10.1007/s00520-019-04861-7

Cited by 4 publications

(9 citation statements)

References 18 publications

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“…Median age of CCS' offspring was 7 years in the first and 4 years in the second wave. Gender distribution of CCS' offspring was well balanced in both study waves [13]. Participants were more likely to be female (p < 0,05), under the age of 35 years at time of survey (p < 0,05), under the age of 10 years at time of diagnosis (p < 0,05) and moderately to highly educated (p < 0,01).…”

Section: Participantsmentioning

confidence: 96%

“…Our questionnaire was developed in accordance to the questionnaire of the KiGGS baseline study. More details on our study design have been published previously [1,13].…”

Section: Study Design and Settingmentioning

confidence: 99%

“…We considered diagnosis of the CCS parent, parent's anxiety level, general health status of the child and social determinants (educational status, employment status, household income, medical insurance, migration status). Details on background variables have been published by Schuster et al in 2019 [13].…”

Section: Variablesmentioning

confidence: 99%

“…Participants were more likely to be female (p < 0,05), under the age of 35 years at time of survey (p < 0,05), under the age of 10 years at time of diagnosis (p < 0,05) and moderately to highly educated (p < 0,01). We previously published detailed results of non-responder analysis of both study waves [13] ▶Table 1.…”

Section: Participantsmentioning

confidence: 99%

“…Results of comparison between responders and non-responders including characteristics (gender, age at survey, age at diagnosis, diagnosis and educational level). Significance level: p<0,05 (published before: Schuster et al[13])…”

mentioning

confidence: 99%

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Vaccinations and Screening Examinations – Prevention Awareness Among Children of Childhood Cancer Survivors in Germany

et al. 2020

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Background Immunisation levels and attendance of preventive screening examinations indicate primary health prevention awareness. We investigated participation among German childhood cancer survivors’ (CCS’) offspring in our national offspring study. Patients and methods CCS with biological children were surveyed on their offspring’s vaccination levels and attendance of preventive screening examinations by questionnaire. Data from the German general population was available for matched-pair analysis (KiGGS study, Robert Koch-Institute, n=17,641). Results Overall, 852/1,299 (65,6%) CCS completed 1,340 questionnaires regarding their childrenʼs health. In comparison with the general population, coverage of tetanus, diphtheria and pertussis inoculations were similar (tetanus 99,1 vs. 98,4%). Measles, mumps and rubella vaccinations were carried out significantly more often by CCS’ offspring (rubella 96,1 vs. 91,7%). Throughout all age groups, preventive screening examinations were attended significantly more often by CCS’ offspring. Parentʼs anxiety regarding their offspring’s health was identified to be a confounding variable for vaccination rates. Discussion and conclusion CCS’ offspring showed comparable to significantly higher participation levels of recommended vaccinations and screening examinations than their peers from the German general population. In contrast to the general population the attendance of CCS’ offspring did not decrease with rising age. CCS’ own experiences and increased worry about their children’s health may lead to a higher prevention awareness. This should be considered in counselling parents with a cancer history.

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Section: Participantsmentioning

confidence: 96%

“…Our questionnaire was developed in accordance to the questionnaire of the KiGGS baseline study. More details on our study design have been published previously [1,13].…”

Section: Study Design and Settingmentioning

confidence: 99%

Section: Variablesmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

mentioning

confidence: 99%

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Vaccinations and Screening Examinations – Prevention Awareness Among Children of Childhood Cancer Survivors in Germany

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Health‐related quality of life of children born to childhood cancer survivors in Germany

et al. 2021

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Objective Rising childhood cancer survival rates have increased the importance of health‐related quality of life (HRQL) assessment. While survivors show comparable HRQL to peers, concerns that cancer treatment could impact the health of prospective children were reported. No previous publications address HRQL of childhood cancer survivor offspring. Methods We assessed survivor offspring HRQL using the parental KINDL questionnaire. Matched‐pair analysis was conducted with data from the general population (KiGGS study) using age, gender and education (1:1, n = 1206 cases). Multivariate analyses were conducted to detect the influence of parental diagnose and treatment on offspring HRQL. Results Overall, within KINDL dimensions, survivors reported comparable to higher HRQL for their children than the general population. Survivor parents reported significantly (p < 0.001) higher psychological (86.7% vs. 83.0%, Cohen's d = 0.3) and self‐esteem (79.1% vs. 73.3%, Cohen's d = 0.5) well‐being scores for younger children (3–6‐year‐olds). As time since diagnosis increased, parents reported higher well‐being scores. Accordingly, recently diagnosed survivors reported significantly lower psychological well‐being scores (p = 0.28; OR = 0.457; 95% CI = 0.228–0.918) for their children. With increasing age, average HRQL scores decreased in both cohorts; yet, this drop was less pronounced for survivor offspring. The biggest difference between age groups (7–10‐ vs. 14–17‐year‐olds) was found for school‐specific well‐being (6.2‐point drop in survivor offspring vs. 18.2‐point drop in KiGGS offspring). Conclusion Comparable to higher parentally assessed HRQL was reported for survivor offspring compared to peers. These findings are reassuring and consistent with self‐reported HRQL in childhood cancer survivors. Type of parental cancer diagnosis and treatment showed no negative impact on offspring HRQL.

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Health outcomes in offspring born to survivors of childhood cancers following assisted reproductive technologies

et al. 2020

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Purpose An increasing number of childhood cancer survivors are using assisted reproductive technologies (ART) to overcome treatment-related fertility impairment. We report perinatal and health outcomes of offspring born to survivors following ART. Methods The FeCt Multicenter Offspring Study surveyed the health of offspring of childhood cancer survivors. Health outcomes in offspring born to survivors following ART (n = 57, 4.6%) or after spontaneous conception (n = 1182) were assessed in the German cohort (n = 1239) using bivariate analysis. Findings were put into the context of the general German population by health outcome assessment in 1:1 matched-pair analysis (n = 2478). Results Nearly twice the survivors used ART compared with numbers reported for the German general population (4.6% vs. 2.6%). Successful pregnancies were achieved after a median of two cycles, mainly using non-cryopreserved oocytes/sperm. Multiple sibling births (p < 0.001, 28.1% vs. 3.0%) and low birth weight (p = 0.008; OR = 2.659, 95% CI = 1.258-5.621) occurred significantly more often in offspring born to survivors who utilized ART than spontaneously conceived children, whereas similar percentages were born preterm or too small for their gestational age. ART did not increase the prevalence of childhood cancer or congenital malformations in offspring born to survivors. Conclusion ART use by childhood cancer survivors was successful with both fresh and cryopreserved oocytes/sperm, and did not influence perinatal health or health outcomes when known confounders were taken into account. Implications for Cancer Survivors Oncofertility is an important component of patient care. Our study implicates that the utilization of ART by adult survivors of childhood cancer does not put offspring at additional risk for adverse perinatal or health outcomes.

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Ambulant health care utilisation among children of childhood cancer survivors in Germany

Cited by 4 publications

References 18 publications

Vaccinations and Screening Examinations – Prevention Awareness Among Children of Childhood Cancer Survivors in Germany

Vaccinations and Screening Examinations – Prevention Awareness Among Children of Childhood Cancer Survivors in Germany

Health‐related quality of life of children born to childhood cancer survivors in Germany

Health outcomes in offspring born to survivors of childhood cancers following assisted reproductive technologies

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