Ambulatory 24-Hour Blood Pressure Versus Self-Measured Blood Pressure in Pharmacologic Trials

Mengden, T; Weisser, Burkhard; Vetter, W

doi:10.1097/00005344-199412001-00005

Cited by 13 publications

(5 citation statements)

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“…Several studies in the literature [53][54][55][56][57][58] have considered heart rate measurement as 1 more parameter to analyze the behavior of the cardiovascular variables obtained through ambulatory monitoring during 24 hours. Our results show a significant increase (2.5%) in mean heart rate during 24 hours and in the wakefulness period when ABPM after resistive exercise was compared with ABPM after aerobic exercise; on the other hand, no statistically significant difference was observed when control monitoring was compared with ABPM after aerobic exercise and after resistive exercise.…”

Section: Discussionmentioning

confidence: 99%

Monitorização ambulatorial da pressão arterial em indivíduos normotensos submetidos a duas sessões únicas de exercícios: resistido e aeróbio

Bermudes¹,

Vassallo²,

Vasquez³

et al. 2004

Arq. Bras. Cardiol.

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Section: Discussionmentioning

confidence: 99%

Monitorização ambulatorial da pressão arterial em indivíduos normotensos submetidos a duas sessões únicas de exercícios: resistido e aeróbio

Bermudes¹,

Vassallo²,

Vasquez³

et al. 2004

Arq. Bras. Cardiol.

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“…16,17,40,41 Home BP and ambulatory BP are not influenced by the placebo effect or observer bias, and can detect small changes in BP caused by pharmacological and non-pharmacological interventions in a limited number of subjects. [18][19][20] Therefore, our study does not support the concept that fibrates exert a clinically relevant antihypertensive effect on hypertensive patients with dyslipidemia. Earlier studies that showed reductions in BP with fibrates used only casual BP measurements, and the two studies 13,37 were not controlled.…”

Section: Discussionmentioning

confidence: 71%

“…16,17 Home BP measurement and ambulatory BP monitoring can detect small changes in BP caused by pharmacological and non-pharmacological interventions in a limited number of subjects. [18][19][20] In the present study, we examined the effects of bezafibrate on office, home and 24-h BP, as well as lipid and glucose metabolism, in hypertensive patients with dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

Effect of bezafibrate on office, home and ambulatory blood pressure in hypertensive patients with dyslipidemia

et al. 2012

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It has been suggested that fibrates, lipid-lowering agents with a peroxisome proliferator-activated receptor-α agonistic property, lower blood pressure (BP) in some experimental models of hypertension. However, the effect of fibrates on BP in humans has been inconsistent, and there are few studies using home or ambulatory BP monitoring. We investigated the effects of bezafibrate on office, home and ambulatory BP in hypertensive patients with dyslipidemia. Thirty-two essential hypertensive patients with dyslipidemia (6 men and 26 women, mean age 65±8 years old) were assigned to a control period and a bezafibrate period (200 mg twice daily) for 8 weeks each in a randomized crossover manner. Bezafibrate significantly reduced serum triglyceride, total and low-density lipoprotein-cholesterol, blood glucose, plasma insulin, the homeostasis model assessment ratio and increased high-density lipoprotein-cholesterol. Compared with the control period, changes in office, home and 24-h BP with bezafibrate were -0.7±2.1/-1.6±1.2 mm Hg, +0.9±1.0/-0.5±0.6 and +0.8±1.4/-0.6±0.9 mm Hg, respectively. None of these differences in BP was significant. In conclusion, bezafibrate improved lipid metabolism and insulin sensitivity but did not affect office, home or ambulatory BP in hypertensive patients with dyslipidemia. Fibrates do not appear to lower BP in patients with essential hypertension.

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“…• In comparison to the gold standard ABPM, home self-measurements taken 12 to 24 hours after intake of medication allowed a conclusion to be drawn about the 24-hour efficacy of the treatment (18,19).…”

Section: Comparison Of Office Blood Pressure Abpm and Home Blood Pressure In Treatment Studiesmentioning

confidence: 99%

“…• Furthermore, the pharmacodynamic effects of variable adherence were captured by home blood pressure measurement (12,18). Hypertension management-evaluating dose titration studies reported the following results:…”

Section: Comparison Of Office Blood Pressure Abpm and Home Blood Pressure In Treatment Studiesmentioning

confidence: 99%

Monitoring of Treatment for Arterial Hypertension

Mengden¹,

Weisser²

2021

Deutsches Ärzteblatt International

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Background: The treatment of arterial hypertension can be monitored by office blood pressure (office BP), home blood pressure (home BP), or 24 hours ambulatory blood pressure (ABPM). In this review, we present current recommendations from Germany and from international guidelines as well as the findings of the main studies on the use of these methods to guide treatment.Methods: This review is based on pertinent publications retrieved by a selective search in PubMed up to and including March 2020. Special attention was paid to guidelines and position papers.Results: The guidelines offer heterogeneous recommendations for treatment monitoring. Home BP is the most reproducible method, with test−retest correlation coefficients of 0.91/0.86 (systolic/diastolic), in comparison to office BP (0.77/0.76). Two meta-analyses revealed better blood pressure control with home measurement than with usual care (systolic, −3.2 to −8.9 mmHg). A meta-analysis of randomized controlled trials also suggests that home measurement promotes adherence. In the randomized and controlled TASMINH4 trial, the home BP group with telemetric surveillance achieved better blood pressure control than the group with treatment titration based on office BP (systolic −4.7 [CI: −7; −2.4] mmHg, diastolic −1.3 [−2.5; 0.02] mmHg). With ABPM, patients frequently reported moderate to severe discomfort, limiting its practical applicability.Conclusion: Blood pressure measurement at home is recommended for treatment monitoring, using validated, automatic upper arm devices with data storage and trend analysis. Changes of treatment should be based on average values (28 home measurements) from seven days (two morning and two evening measurements per day). Office BP is mainly used for for screening purposes. There have not yet been any randomized trials comparing the three measuring methods in terms of hard cardiovascular endpoints.

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Ambulatory 24-Hour Blood Pressure Versus Self-Measured Blood Pressure in Pharmacologic Trials

Cited by 13 publications

References 0 publications

Monitorização ambulatorial da pressão arterial em indivíduos normotensos submetidos a duas sessões únicas de exercícios: resistido e aeróbio

Monitorização ambulatorial da pressão arterial em indivíduos normotensos submetidos a duas sessões únicas de exercícios: resistido e aeróbio

Effect of bezafibrate on office, home and ambulatory blood pressure in hypertensive patients with dyslipidemia

Monitoring of Treatment for Arterial Hypertension

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