Ambulatory Blood Pressure in Relation to Plasma and Urinary Manganese

Abstract

The association of blood pressure (BP) with manganese, an essential trace element required for human health, remains poorly studied. In 734 randomly recruited Swiss participants (mean age, 47.5 years; 51.4% women), we related ambulatory BP to two biomarkers, plasma manganese (pMn) and the urinary manganese excretion (uMn). To allow for diurnal variation, we assessed BP and uMn over 24-h and during wakefulness and sleep, using split urine samples. 24-h, day-and night-time systolic/diastolic BPs averaged 119.8/78.1, 123.8/81.2 and 107.0/68.3 mm Hg; the corresponding medians uMn were 199.5, 83.0, 51.5 mol and median pMn 0.52 g/L. In analyses dichotomized by the median of the biomarkers, greater pMn was associated with higher 24-h systolic/diastolic BP (+4.1/+2.3 mm Hg; P≤0.0003), greater daytime uMn with lower daytime BP (-3.5/-1.9 mm Hg; P≤0.0067) and greater nighttime uMn with higher nighttime BP (+2.9/+1.2 mm Hg; P≤0.046). In multivariable-adjusted analyses, significance (P≤0.030) was retained for the positive association of 24-h and daytime diastolic BP with pMn and for systolic BP in relation to uMn at night. The association sizes for a twofold increment in the biomarkers amounting to 0.77 mm Hg (95% confidence interval [CI], 0.08-1.47 mm Hg), 0.97 (CI, 0.20-1.76) and 1.33 (CI, 0.20-2.50 mm Hg), respectively. In conclusion, there were positive associations between diastolic BP and pMn over 24 h and during daytime and between systolic BP and uMn at night.

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

“…The possible mechanisms of cardiovascular toxicity induced by Mn include changes in autonomic nerve function, Ca 2+ channel obstruction, myocardial mitochondrial damage, reduction of dopamine and 5-hydroxytryptophane, interference with cholinesterase synthesis, and reduction of superoxide dismutase activity ( 228 ). In addition, there were positive associations between diastolic blood pressure and plasma Mn over 24 hours and during daytime and between systolic blood pressure and urinary Mn at night ( 229 ).…”

In Utero Exposure to Heavy Metals and Trace Elements and Childhood Blood Pressure in a U.S. Urban, Low-Income, Minority Birth Cohort

“…A few studies reported an inverse association of Se and BP (Nawrot et al 2007;Salonen et al 1988), but an analysis of the NHANES 2003-2004 data found that higher serum Se levels were associated with a higher prevalence of hypertension in U.S. adults (Laclaustra et al 2009). For Mn, an analysis of the U.S. NHANES 2011-2014 data found that higher urinary Mn levels were associated with lower BP in adults (Wu et al 2017), whereas another study in Swiss adults found a positive association of plasma and urine Mn with BP (Zhang et al 2020a). It should also be noted that many previous studies did not examine (and thus may have missed) the possible nonlinear associations of these two elements with BP.…”

Associations of blood pressure in the third trimester and risk of venous thromboembolism postpartum

“…It is also possible that nutrients such as manganese is involved in the mechanisms. Prior study found that both SBP and DBP were associated with manganese levels in the body, 46 whereas higher levels of manganese‐dependent enzyme were correlated with increased antioxidant activity in oxidative stress conditions, 47 possibly leading to elevated risk of VTE. More experimental studies are warranted to underline the potential mechanisms.…”