Ambulatory blood pressure measurement in the evaluation of blood pressure lowering drugs

O’Brien, Eoin; Jl, Cox; O’Malley, K

doi:10.1097/00004872-198904000-00001

Cited by 32 publications

(21 citation statements)

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“…In all these patients, at least 50% (i.e., between 58.3% and 100%) of all waking diastolic pressures were above 90 mmHg. A similar circadian pattern of ambulatory blood pressure was observed as in other studies [20,[23][24][25], with lower blood pressure at night than during the waking hours and with the highest values in the early morning [25]. According to the criteria of White and Morganroth [18], the included patients have also nighttime ambulatory blood pressure in the hypertensive range.…”

Section: Discussionsupporting

confidence: 81%

“…In contrast, 3 weeks of placebo did not significantly change the ambulatory blood pressure, confirming the reproducibility of the ambulatory recording. This absence of a placebo effect for ambulatory blood pressure monitoring has been reported before [26,27], and, if confirmed, would greatly simplify the design and conduct of efficacy studies of antihypertensive drugs [19,20].…”

Section: Discussionmentioning

confidence: 61%

“…It is now established that noninvasive ambulatory monitoring strengthens antihypertensive trials by documenting the efficacy and duration of treatment [10]. Ambulatory monitoring of blood pressure improves the accuracy of trials and may significantly reduce the number of patients needed in such studies [18][19][20]. The use of noninvasive ambulatory blood-pressure monitoring in the present study allowed us to confirm the antihypertensive efficacy and the 24-hour duration of action of once-a-day treatment with the new slow-release formulation of diltiazem.…”

mentioning

confidence: 99%

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Twenty-Four hour ambulatory blood pressure profile of a new slow-release formulation of diltiazem in mild to moderate hypertension

Dupont¹,

Coupez²,

Jensen³

et al. 1991

Cardiovasc Drug Ther

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Twelve patients with a mild to moderate essential hypertension were included in a double-blind, balanced, randomized placebo-controlled cross-over study to assess the efficacy and duration of action of a new slow-release formulation of diltiazem (300 mg) given once daily for 3 weeks. All office blood pressure measurements were done 24 hours after drug intake. In order to improve the accuracy of the trial, 24-hours non-invasive ambulatory blood pressure monitoring (Spacelabs 90207 system) were performed as well. Diltiazem significantly lowered supine and standing systolic and diastolic office blood pressure (by 16.9/12.7 mmHg and by 17.3/13.8 mmHg, respectively), without changing office heart rate. Diltiazem also significantly lowered ambulatory blood pressure measured over 24 hours, as well as ambulatory heart rate. The blood pressure lowering effect was most pronounced during the daytime period and did not reach statistical significance during the sleeping hours. The treatment was well tolerated, and there were no significant side effects. The results confirm the antihypertensive efficacy of diltiazem LP 300 mg once daily during the daytime and during the early morning blood pressure rise, without inducing nocturnal hypotension.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 61%

mentioning

confidence: 99%

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Twenty-Four hour ambulatory blood pressure profile of a new slow-release formulation of diltiazem in mild to moderate hypertension

Dupont¹,

Coupez²,

Jensen³

et al. 1991

Cardiovasc Drug Ther

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“…1 These devices thus record only a fraction of the blood pressures occurring. 2 To avoid artifactual recordings the subject has to be (nearly) immobile during the measurement, which means that readings during episodes of motion and exercise cannot be obtained.…”

Section: Feasibility Of Ambulatory Continuous 24-hourmentioning

confidence: 99%

“…(1) in the center contains, among other components, a TEAC HR-10J cassette tape recorder (2) and a lithium battery pack (3) and can be carried by a belt (4). A cable (5) connects to the patient front-end box (6).…”

Section: Feasibility Of Ambulatory Continuous 24-hourmentioning

confidence: 99%

Feasibility of ambulatory, continuous 24-hour finger arterial pressure recording.

et al. 1993

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We tested Portapres, an innovative portable, battery-operated device for the continuous, noninvasive, 24-hour ambulatory measurement of blood pressure in the finger. Portapres is based on Finapres, a stationary device for the measurement of finger arterial pressure. Systems were added to record signals on tape, to alternate measurements between fingers automatically each 30 minutes, and to correct for the hydrostatic height of the hand. We compared the pressure as measured by Portapres with contralateral intrabrachial pressure measured with an Oxford device. Results were obtained in eight volunteers and 16 hypertensive patients. Time lost due to artifact was about 10% for each device. In two patients a full 24-hour Oxford profile was not obtained. In the remaining 22 subjects finger systolic, diastolic, and mean pressures differed +1 (SD 9), -8 (6), and -10 (6) mmHg, respectively, from intrabrachial pressure. These diastolic and mean pressure underestimations are similar to what was found earlier for Finapres, are typical for the technique, and are systematic. Avoiding brisk hand movements resulted in fewer waveform artifacts. The hand had to be kept covered to continue recording at low outside temperatures. Sleep was not disturbed by Portapres, and arterial pressure showed a marked fall during siesta and nighttime. There were no major limitations in behavior, and no discomfort that originated from continuous monitoring was reported.

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Variability of Indirect Methods Used to Determine Blood Pressure

Aa²,

Rb³

et al. 1992

Arch Intern Med

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Ambulatory blood pressure measurement in the evaluation of blood pressure lowering drugs

Cited by 32 publications

References 0 publications

Twenty-Four hour ambulatory blood pressure profile of a new slow-release formulation of diltiazem in mild to moderate hypertension

Twenty-Four hour ambulatory blood pressure profile of a new slow-release formulation of diltiazem in mild to moderate hypertension

Feasibility of ambulatory, continuous 24-hour finger arterial pressure recording.

Variability of Indirect Methods Used to Determine Blood Pressure

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