PURPOSE Current offi ce blood pressure measurement (OBPM) is often not executed according to guidelines and cannot prevent the white-coat effect. Serial, automated, oscillometric OBPM has the potential to overcome both these problems. We therefore developed a 30-minute OBPM method that we compared with daytime ambulatory blood pressure.METHODS Patients referred to a primary care diagnostic center for 24-hour ambulatory blood pressure monitoring (ABPM) had their blood pressure measured using the same validated ABPM device for both ABPM and 30-minute OBPMs. During 30-minute OBPM, blood pressure was measured automatically every 5 minutes with the patient sitting alone in a quiet room. The mean 30-minute OBPM (based on t = 5 to t = 30 minutes) was compared with mean daytime ABPM using paired t tests and the approach described by Bland and Altman on method comparison.
RESULTSWe analyzed data from 84 patients (mean age 57 years; 61% female). Systolic and diastolic blood pressures differed from 0 to 2 mm Hg (95% confidence interval, -2 to 2 mm Hg and from 0 to 3 mm Hg) between mean 30-minute OBPM and daytime ABPM, respectively. The limits of agreement were between -19 and 19 mm Hg for systolic and -10 and 13 mm Hg for diastolic blood pressures. Both 30-minute OBPM and daytime ABPM classifi ed normotension, whitecoat hypertension, masked hypertension, and sustained hypertension equally.
CONCLUSIONSThe 30-minute OBPM appears to agree well with daytime ABPM and has the potential to detect white-coat and masked hypertension. This fi nding makes 30-minute OBPM a promising new method to determine blood pressure during diagnosis and follow-up of patients with elevated blood pressures. Ann Fam Med 2011;9:128-135. doi:10.1370/afm.1211.
INTRODUCTIONT he Framingham and the SCORE (systematic coronary risk evaluation) risk functions, both developed to assess the risk of cardiovascular disease, are based on standardized offi ce blood pressure measurements (OBPMs).1,2 Despite guidelines that advocate the relevance of well-executed, standardized OBPM to prevent several forms of bias, 3,4 it is well known that most caregivers do not execute OBPM strictly according to these guidelines. 5,6 In addition, up to one-quarter of patients is prone to the white-coat effect (in which patients exhibit elevated blood pressure in a clinical setting but not in other settings), which infl uences cardiovascular risk profi ling as well. 7,8 This white-coat effect cannot be overcome by standardized OBPM. As a consequence, the determined cardiovascular risk will be incorrect in an estimated 25% of patients and may lead to under-or overtreatment.To enable a more precise determination of cardiovascular risk, OBPM should be free from (observer) bias and the white-coat effect. The mea-
129BLO OD PR ES SUR E ME A SUR EMENT surement should be uniform, easy to execute correctly for all types of health care personnel (doctors, practice assistants, practice nurses, research assistants, etc), and straightforward to implement in daily practice.Fortunately,...