Ambulatory blood pressure monitoring can play an integral role in patient selection, dosage adjustment and efficacy assessment in clinical trials of antihypertensive agents

Effects of long-acting ACE inhibitor (temocapril) and long-acting Ca channel blocker (amlodipine) on 24-h ambulatory BP in elderly hypertensive patients

“…11 In this study, we confirmed this finding in dippers. However, the antihypertensive effects of temocapril did not persist for 24-h in non-dippers, ie, the reductions in night time BPs and morning BPs were smaller than those caused by amlodipine.…”

Differential effects of antihypertensive drugs with differing pharmacological properties on the basal ambulatory blood pressure

“…Basing the antihypertensive therapy on the clinic BP can induce an overestimation [26][27][28][29] or underestimation of its efficacy mainly due to white-coat effect. [29][30][31][32] The prevalence of isolated clinic hypertension (white coat hypertension) in drug trials seems to be extremely high. 33 In the present study, 10.3% of subjects with clinic SBP у150 and DBP у90 mm Hg had isolated clinic hypertension when normotension was defined as ambulatory SBP Ͻ135 and DBP Ͻ80 mm Hg.…”

Method of Mean Value Calculation as an Additional Source of Variability in Ambulatory Blood Pressure Measurement

“…5 Furthermore, its use is recommended by international health authorities based on its many advantages over office BP measurements. 6,7 Before their market release, ambulatory BP (ABP) monitors must pass through extensive validation protocols, as recommended by international institutions. [8][9][10] Moreover, detailed guidelines have also been published concerning the correct and optimal use of ABP devices by health-care providers and patients, the use of appropriate cuff sizes, the definition of a valid ABP recording and adequate recording of BP measurements.…”