Ambulatory Blood Pressure Monitoring in Children and Adults Prenatally Exposed to Dexamethasone Treatment

Karlsson, Leif; Wallensteen, Lena; Nordenström, Anna; Krmar, Rafael T.; Lajić, Svetlana

doi:10.1210/clinem/dgac081

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…The numbers of unaffected subjects treated with DEX are substantially larger and hence easier to perform meaningful statistical analyses. Although height, weight, BMI, heart rate and blood pressure were comparable between DEX-treated participants and population controls ( 104 , 105 ), we did find differences in terms of beta cell function in the Swedish cohort ( 105 ). Indeed, in our child–adult cohort, age 5–26 years, DEX-treated healthy subjects ( n = 40) had lower HOMA-B index compared to controls, which was only the case for girls ( n = 18).…”

Section: Outcomes Of Prenatal Dex Treatment In Cahcontrasting

confidence: 61%

An update on the long-term outcomes of prenatal dexamethasone treatment in congenital adrenal hyperplasia

Westeinde

Karlsson

Messina

et al. 2023

Endocrine Connections

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First-trimester prenatal treatment with the glucocorticoid (GC) dexamethasone (DEX) in pregnancies at risk for classic congenital adrenal hyperplasia (CAH) is associated with ethical dilemmas. Though effective in reducing virilisation in girls with CAH, it entails exposure to high doses of GC in foetuses that do not benefit from the treatment. The current paper provides an update on the literature on outcomes of prenatal DEX treatment in CAH cases and unaffected subjects. Long-term follow up research is still needed to determine treatment safety. In addition, advances in early prenatal diagnostics for CAH and sex-typing, as well as studies assessing dosing effects of DEX may avoid unnecessary treatment and improve treatment safety.

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Section: Outcomes Of Prenatal Dex Treatment In Cahcontrasting

confidence: 61%

An update on the long-term outcomes of prenatal dexamethasone treatment in congenital adrenal hyperplasia

Westeinde

Karlsson

Messina

et al. 2023

Endocrine Connections

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“…Ïîÿâà äåôåêò³â åíäîòåë³þ ó öèõ ì³ñöÿõ ïðèçâîäèòü äî ³í³ö³àö³¿ îêñèäàòèâíîãî ñòðåñó òà çàïàëüíèõ ïðîöåñ³â [1]. Â³äîìî, ùî ñòðåñ ìîaeå ïðèçâîäèòè äî òðàíçèòîðíîãî ï³äâèùåííÿ ÀÒ [2,3]. Íå âèâ-÷åíî äîñòàòíüî, ÿêî¿ ñàìå ïðèðîäè ïîäðàçíèê ìàº áóòè, ÿê äîâãî â³í ìàº ä³ÿòè, ùîá ïðèçâåñòè äî çíà÷íèõ íàñë³äê³â, ÿê âèçíà÷èòè ñà-Material and Methods.…”

Section: âñòóïunclassified

Impact of Vitamin E and Selenium Intake on Antioxidant Protection Indicators During Physical Exertion in Individuals With Hypertension

Dronyk,

Dutka,

Chmyr

et al. 2023

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Hypertension remains one of the main problems in modern medicine since it is a pathogenetic factor leading to a large number of cardiovascular diseases and premature death. The aim of the study is to measure and compare the levels of sulfhydryl groups in plasma and blood as well as reduced glutathione of erythrocytes in patients with stage II hypertension before and after engaging in a controlled physical exercise taking into account the intake of vitamin E and selenium. Material and Methods. There were 60 patients with stage II hypertension and 30 relatively healthy individuals. The individuals under observation performed a two-stage physical exercise on a stationary bicycle ergometer with the intensity, corresponding to 50 and 75% of the maximum oxygen consumption by the body. The overall duration of each stage of the physical exercise accounted for 5 minutes with a three-minute break to rest in between. Blood was taken from the ulnar vein before the cardiac stress test and 5 minutes after it. The content of sulfhydryl groups in plasma and erythrocytes, as well as reduced glutathione of erythrocytes was measured in patients before and after the physical exercise. The examination was conducted twice - before and after the intake of vitamin E and selenium. Results and Discussion. Since the immediate response to a cardiac stress test performed on a stationary bicycle is shown by changes in the level of non-protein-bound sulfhydryl groups of erythrocytes (the level decreases), it can be assumed that they are involved in the formation of the primary compensatory reaction in response to physical exercise in individuals suffering from arterial hypertension. Conclusion. Thus, the decrease in the level of non-protein-bound sulfhydryl groups of erythrocytes enables to assess the degree of stress that affects the human body, as well as the antioxidant protection enhancement in patients with hypertension after taking vitamin E and selenium both before and after engaging in physical exercise.

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“…Відомо, що стрес може призводити до транзиторного підвищення АТ [4,5], але питання, чи може гострий стресорний подразник достатньої сили призвести до постійно підвищеного АТ (тобто до АГ), ще залиша-ється предметом дискусій [6]. Не вивчено достатньо, якої саме природи подразник має бути, як довго він має діяти, щоб призвести до значних наслідків, як визначити саме його зв'язок із підвищенням АТ або ж як оцінити кількісно його силу [7,8].…”

Section: вступunclassified

Changes in the cortisol level under the influence of physical exertion in patients with hypertension and in practically healthy individuals

Dronyk

Dutka

Chmyr

et al. 2023

Mìžnarodnij endokrinologìčnij žurnal

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Background. Today, there are difficulties with the prevention and diagnosis of early stages of hypertension, especially in active and able-bodied young people. Among the factors that potentiate an increase in blood pressure, one of the components is chronic stress, which a person often faces in modern society. The purpose of study is to evaluate and compare blood cortisol and plasma malondialdehyde content in healthy individuals and in patients with stage II hypertension before and after dosed exercises. Materials and methods. Thirty patients with stage II hypertension and 10 practically healthy persons were examined. Subjects performed two-stage physical exercises on a bicycle ergometer with an intensity corresponding to 50 and 75 % of the appropriate maximum oxygen consumption of the body. The duration of the load was equal to 5 minutes at each stage with a three-minute rest between them. Blood was taken from the ulnar vein before cycling ergometry and 5 minutes after it. Blood cortisol and plasma malondialdehyde content were determined in patients before and after exercises. Results. A significant increase in cortisol content after exercises was noted in healthy individuals against the background of some decrease in patients with hypertension. It has been suggested that since people with high blood pressure already have an elevated initial level of cortisol, their threshold of stress sensitivity to physical exertion is increased. Submaximal bicycle ergometric load does not lead to an increase in blood cortisol levels in hypertensive patients. Conclusions. The background higher level of cortisol in individuals with hypertension does not increase under the influence of submaximal dosed exercises. An increase in the level of malondialdehyde can be considered a marker of the degree of stress for assessing the power of physical exertion. In view of the above, it can be stated that the activation of the sympathoadrenal system under the influence of emotional stress leads to an increase in blood pressure. There is sufficient evidence that psycho-emotional stress is a cause of white-coat hypertension and hypertension in the workplace.

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Ambulatory Blood Pressure Monitoring in Children and Adults Prenatally Exposed to Dexamethasone Treatment

Cited by 6 publications

References 48 publications

An update on the long-term outcomes of prenatal dexamethasone treatment in congenital adrenal hyperplasia

An update on the long-term outcomes of prenatal dexamethasone treatment in congenital adrenal hyperplasia

Impact of Vitamin E and Selenium Intake on Antioxidant Protection Indicators During Physical Exertion in Individuals With Hypertension

Changes in the cortisol level under the influence of physical exertion in patients with hypertension and in practically healthy individuals

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