Amburana cearensis: Pharmacological and Neuroprotective Effects of Its Compounds

Silva, Juliana Helena Castro E; Ferreira, Rafael Short; Pereira, Érica Patrícia Lima; Braga-de-Souza, Suzana; Almeida, Monique Marylin Alves de; Santos, Cleonice Creusa dos; Butt, Arthur M.; Caiazzo, Elisabetta; Capasso, Raffaele; Silva, Víctor Diógenes Amaral da; Costa, Sílvia Lima

doi:10.3390/molecules25153394

Cited by 27 publications

(21 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…was the most versatile species, whose barks (stem) and seeds were indicated for the treatment of seven diseases (chickenpox, infantile colic, inflammation in general, tooth eruptions, the flu, antipyretic and expectorant), with scientifically proven uses, as stated by Canuto (2008). Silva et al (2020) state that coumarins, a chemical constituent naturally present in various parts of the plant, known pharmacologically as antioxidants and anti-inflammatory drugs, also have a neuroprotective function, due to their ability to reduce oxidative stress, inflammation and neuronal death. Agra (1996) also adds that it is threatened with extinction in areas of Caatinga, due to exploitation for timber purposes in the region of Cariris Velhos/CE.…”

Section: Resultsmentioning

confidence: 99%

The use and diversity of medicinal flora sold at the open market in the city of Oeiras, semiarid region of Piauí, Brazil

Oliveira

Vieira

Amorim

et al. 2021

Ethnobot. Res. App.

View full text Add to dashboard Cite

Background: Medicinal plants are important resources in people's health care. In urban areas, they are commercialized in open markets. The goal of this paper is to know the medicinal plants marketed in the Oeiras/PI free trade fair and the associated knowledge attached to it. Methods: Interviews were carried out with the seven licensees who traded medical ethnospecies at the free trade fair of the municipality, through the application of semi structured forms. Species similarity and richness were calculated using the Shannon-Wiener and Jaccard index. For the informant's consensus Factor, the Loyalty Level was calculated.Results: We identified 60 species, belonging to 34 botanical families, with greater representativity for Fabaceae (16 ssp.). The most used plant organs were leaves (29,9%) and stems (20,8%) and the predominant preparation method of herbal medicine was tea (decoction and infusion, 26,9% and 20,8%, respectively). Ximenia americana L. showed greater use and Amburana cearensis (Allemão) AC Sm. was the most versatile species. The most usual citation was for the treatment of symptoms of the respiratory and genitourinary systems disorders. It was verified that the fair is an important space for maintenance, (re) construction and diffusion of the local culture on the use of medicinal plants.Conclusions: Public policies should include these spaces in the establishment of standards and specific guidelines that guarantee the permanence of sellers and the safe and sustainable use of flora resources.

show abstract

Section: Resultsmentioning

confidence: 99%

The use and diversity of medicinal flora sold at the open market in the city of Oeiras, semiarid region of Piauí, Brazil

Oliveira

Vieira

Amorim

et al. 2021

Ethnobot. Res. App.

View full text Add to dashboard Cite

show abstract

“…Coumarin is a natural phenolic compound from Solanaceae , Rutaceae , and Amburana cearensis [ 54 , 55 ]. It has anti-inflammatory and analgesic functions [ 56 , 57 ].…”

Section: Natural Pharmacological Productsmentioning

confidence: 99%

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Chen

Zhang

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Intervertebral disc degeneration (IDD) is one of the main causes of low back pain (LBP), which severely reduces the quality of life and imposes a heavy financial burden on the families of affected individuals. Current research suggests that IDD is a complex cell-mediated process. Inflammation, oxidative stress, mitochondrial dysfunction, abnormal mechanical load, telomere shortening, DNA damage, and nutrient deprivation contribute to intervertebral disc cell senescence and changes in matrix metabolism, ultimately causing IDD. Natural products are widespread, structurally diverse, afford unique advantages, and exhibit great potential in terms of IDD treatment. In recent years, increasing numbers of natural ingredients have been shown to inhibit the degeneration of nucleus pulposus cells through various modes of action. Here, we review the pharmacological effects of natural products on nucleus pulposus cells and the mechanisms involved. An improved understanding of how natural products target signalling pathways will aid the development of anti-IDD drugs. This review focuses on potential IDD drugs.

show abstract

“…A large number of plant species are now being used in cancer treatment or prevention. Accumulating evidence suggests that plant species have anticancer properties (Alam et al, 2016;Greenwell & Rahman, 2015;Islam et al, 2015;Martínez et al, 2020;Silva et al, 2020). Approximately 35,000 plants have been assessed for possible anticancer activities by the National Cancer Institute (NCI), and of these, about 3,000 plant species have shown reproductive anticancer activity (Desai et al, 2008;Iqbal et al, 2020;Vieira et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line

Reza

Haque

Sarker

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

In the present study, the aerial parts of Achyranthes ferruginea underwent investigation of their in vitro antioxidant and free radical‐scavenging activities in cell‐free conditions, their phytoconstituents using gas chromatography‐mass spectrometry (GC‐MS), and their cytotoxic activity in HeLa cells. A. ferruginea was extracted with 80% methanol and successively fractionated with solvents to yield petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF), and aqueous (AQF) fractions. GC‐MS analysis revealed that CHF contained ten phytoconstituents, including different forms of octadecanoic acid methyl esters. The total antioxidant and ferric‐reducing antioxidant capacities of the extracts and the standard catechin (CA) were as follows: CA >CHF >PEF >CME (crude methanolic extract) >EAF >AQF, and CA >CHF >EAF >PEF >AQF >CME, respectively. CHF showed the highest DPPH‐free radical‐scavenging activity, with a median inhibitory concentration of 10.5 ± 0.28 µg/ml, which was slightly higher than that of the standard butylated hydroxytoluene (12.0 ± 0.09 µg/ml). In the hydroxyl radical‐scavenging assay, CHF showed identical scavenging activity (9.25 ± 0.73 µg/ml) when compared to CA (10.50 ± 1.06 µg/ml). Moreover, CHF showed strong cytotoxic activity (19.95 ± 1.18 µg/ml) in HeLa cells, which was alike to that of the standards vincristine sulfate and 5‐fluorouracil (15.84 ± 1.64 µg/ml and 12.59 ± 1.75 µg/ml, respectively). The in silico study revealed that identified compounds were significantly linked to the targets of various cancer cells and oxidative enzymes. However, online prediction by SwissADME, admetSAR, and PASS showed that it has drug‐like, nontoxic, and potential pharmacological actions.

show abstract

Amburana cearensis: Pharmacological and Neuroprotective Effects of Its Compounds

Cited by 27 publications

References 109 publications

The use and diversity of medicinal flora sold at the open market in the city of Oeiras, semiarid region of Piauí, Brazil

The use and diversity of medicinal flora sold at the open market in the city of Oeiras, semiarid region of Piauí, Brazil

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line

Contact Info

Product

Resources

About