Amebiasis presenting as an acute abdomen

Judy, Kenneth L.

doi:10.1016/0002-9610(74)90031-2

Cited by 15 publications

(28 citation statements)

References 8 publications

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“…It is documented that appendicectomy is difficult to perform due to the friability of the oedematous tissue [21,22]. In the Chicago epidemic of 1933, 41% of 32 patients who underwent appendicectomy died [16]. Surgical management of active amoebic conditions is associated with poor outcome, high morbidity and mortality [18,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Amoebic appendicitis has been documented in patients presenting with acute abdomen in association with caecal disease in 7-40% of fatal cases of amoebiasis [16]. Some workers have stated that amoebic involvement of the appendix arises exclusively or almost exclusively by extension of the infection from the caecum and colon [4,7].…”

Section: Discussionmentioning

confidence: 99%

“…The appendicectomies from these patients reached the pathology laboratory after a delay of 3-5 days, resulting in delayed histopathological 67 diagnosis and treatment. Literature review reveals that the diagnosis of amoebic appendicitis is usually made late in the course of the disease or at autopsy [16]. It is documented that appendicectomy is difficult to perform due to the friability of the oedematous tissue [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…A disease of worldwide distribution, amoebiasis is endemic in tropical countries with suboptimal sanitation facilities [5]. Although the prevalence is therefore highest in under-resourced developing countries with the lowest levels of sanitation, occurrence in developed countries is documented in association with modern travel, high rates of emigration and the existence of high risk groups, such as institutionalised patients and homosexuals [1,16,18]. While the clinicopathological spectrum, morbidity and mortality of invasive intestinal amoebiasis are well recorded in medical literature [6,13,18], clinicopathological reports on isolated amoebic appendicitis (IAA), regarded as a rare intestinal manifestation of invasive amoebiasis globally, are confined mainly to single case reports [2,3,12,17,20,24,25,32].…”

Section: Introductionmentioning

confidence: 99%

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Isolated amoebic appendicitis

et al. 2001

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Amoebiasis, a disease of worldwide distribution, is endemic in tropical countries with suboptimal sanitation facilities. Isolated amoebic appendicitis (IAA) is regarded as a rare manifestation of the disease globally. Because there are no defined clinical features that distinguish IAA from bacterial appendicitis, diagnosis is usually dependent on histopathological examination. A 9-year retrospective study was undertaken to investigate the clinicopathological aspects of IAA. The main complaints were fever and abdominal pain. None of the patients had dysentery. The pre-operative clinical diagnosis was acute appendicitis and acute abdomen in 13 and 8 patients, respectively. In all cases the intra-operative diagnosis was acute appendicitis. Gross pathological appraisal revealed peritonitis and perforation in 19 and 17 cases, respectively. Histopathological examination of these appendices demonstrated appendiceal ulceration, transmural mixed inflammation, haematophagous amoebic trophozoites and necrosis in all cases. Vascular pathology comprised venous and capillary luminal plugging (11 cases), necrotising small vessel vasculitis (11 cases), thrombophlebitis of medium sized veins (9 cases) and arteritis with associated thrombosis (1 case). Organising fibrinopurulent peritonitis was present in 19 cases. Two appendices that appeared normal macroscopically demonstrated ulceration and inflammation that were confined to the mucosa and submucosa. All of 18 patients who were treated with metronidazole survived without further surgery, while three patients who were untreated succumbed to the disease. Appendicectomy, accurate histopathological appraisal thereof and optimal, timely management of IAA were critical to the favourable outcome in the present study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Isolated amoebic appendicitis

et al. 2001

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“…Because there is a high risk of suture breakdown in tissue containing amoebae, resection and anastomosis should be avoided. '7 21 In a necropsy study of fatal amoebic colitis, Azar et Perforation of hepatic abscess into peritoneal cavity.…”

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confidence: 99%