Amebic Liver Abscess in HIV-infected Patients, Republic of Korea

Park, Wan Beom; Choe, Pyoeng Gyun; Hyun, Jae Chun; Kim, Sung-Han; Bang, Ji Hwan; Kim, Hong Bin; Kim, Nam Joong; Oh, Myoung Don; Choe, Kang Won

doi:10.3201/eid1303.060894

Cited by 57 publications

(32 citation statements)

References 10 publications

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“…Similar fi ndings are reported for MSM in Taiwan (4,5). More recently, a study from the Republic of Korea documented invasive amebiasis (amebic liver abscess) in HIV-infected MSM (6). To date, the emergence of E. histolytica infections in MSM seems to be limited to the Asia-Pacifi c region.…”

Section: Discussionsupporting

confidence: 63%

Invasive Amebiasis in Men Who Have Sex with Men, Australia

Stark

Hal

Matthews

et al. 2008

Emerg. Infect. Dis.

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Section: Discussionsupporting

confidence: 63%

Invasive Amebiasis in Men Who Have Sex with Men, Australia

Stark

Hal

Matthews

et al. 2008

Emerg. Infect. Dis.

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“…6 It has been previously reported that stool protozoan carriage occurs at increased rates in men who have sex with men (MSM). 7 Studies from East Asia have recognized E. histolytica as an emerging pathogen in MSM, [8][9][10][11] where sexual activity, especially oro-anal contact, is suggested to be the mode of transmission. 12 There have also been increasing reports from North America and Europe of invasive disease in the MSM population.…”

mentioning

confidence: 99%

Seroprevalence of Entamoeba histolytica Infection among Men Who Have Sex with Men in Sydney, Australia

James¹,

Barratt²,

Marriott³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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A retrospective analysis was undertaken to determine the seroprevalence of Entamoeba histolytica infection in Sydney, Australia. Using an enzyme-linked immunosorbent assay, 429 high risk human immunodeficiency virus (HIV)-infected men who have sex with men (MSM), 446 low risk HIV-uninfected MSM, and 456 HIV-uninfected controls were assessed. Seroprevalence rates were 5.13% for the high risk HIV-infected MSM group, 0.22% for the low risk HIV-uninfected MSM group, and 0.44% for the control group. We found that high risk HIV-infected MSM have a significantly greater seroprevalence of E. histolytica with a relative risk of 22.87, when compared with low risk HIV-uninfected MSM and 11.69 when compared with controls. These findings show that in Sydney, sexually active HIV-infected MSM are at greater risk of developing amoebic disease caused by E. histolytica than HIV-uninfected MSM and the general population.

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“…[1][2][3][4][5][6][7] In several developed countries in Asia, studies have shown that E. histolytica infection has become an emerging parasitic infection in MSM, especially those who are human immunodeficiency virus (HIV) infected. [8][9][10][11][12][13][14] In Japan, 80% of the annually reported 500-600 cases occurred in MSM 10 ; and the seroprevalence of MSM was estimated 13.4-20.4% compared with 1.0% in heterosexuals and 0.8% in prostitutes. 13 In Taiwan, prevalence and incidence of amebiasis are also significantly higher in HIV-infected MSM than healthy controls and heterosexuals.…”

Section: Introductionmentioning

confidence: 99%

“…8,9,14 An increasing trend of invasive amebiasis has been reported in HIV-infected patients seeking HIV care in Korea and Taiwan. 11,15 Similarly, recent diagnosis of cases of invasive amebiasis among MSM or bisexual females with or without traveling to areas endemic for amebiasis raises concerns of spread of E. histolytica infection among persons at risk for HIV transmission in Australia and Canada. [16][17][18] In a cross-sectional study using stool antigen detection and polymerase chain reaction (PCR) from Mexico, 19 where amebiasis is endemic, investigators found that HIV-infected patients appeared to have a higher rate, though not statistically significant, of E. histolytica infection than their sexual partners or close contacts.…”

Section: Introductionmentioning

confidence: 99%

Amebiasis among Persons Who Sought Voluntary Counseling and Testing for Human Immunodeficiency Virus Infection: A Case-Control Study

Hung¹,

Wu²,

Chang³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. This case-control study aimed to characterize the factors associated with amebiasis, defined as presence of anti-Entamoeba histolytica antibody titers of ³ _ 128 by indirect hemagglutination assay, among persons seeking voluntary counseling and testing (VCT) for human immunodeficiency virus (HIV) infection. Between April 2006 and September 2009, 57 of 4,802 persons (1.2%) seeking VCT services were seropositive for E. histolytica infection. Compared with 228 seronegative controls, case subjects were older (odds ratio [OR] for per 1-year increase, 1.098; 95% confidence interval [CI], 1.036, 1.165), less likely to hold bachelor degree or higher (OR, 0.359; 95% CI, 0.152, 0.846), and were more likely to be men who have sex with men (MSM) (OR, 8.382; 95% CI, 2.050, 34.266) and have oral-anal sex (OR, 4.016; 95% CI, 1.711, 9.427) in multiple logistic regression analysis. The MSM, fecal-oral contamination, lower educational achievement, and older age were associated with increased risk for amebiasis among persons seeking VCT for HIV infection.* Address correspondence to Chien-Ching Hung, Department of Internal Medicine, National Taiwan University Hospital, 7 ChungShan South Road, Taipei, Taiwan 100. E-mail: hcc0401@ntu.edu.tw 66 HUNG AND OTHERS previously described.9 After a pilot study to assess the costeffectiveness of detection of E. histoytica in stool specimens in those persons seeking VCT services and HIV care, 21 we have found that E. histolytica in persons who were seronegative for E. histolytica was rarely detectable; among 345 persons who underwent IHA serological assays and specific stool amebic antigen assays, 24 of 36 (66.7%) who were seropositive for E. histolytica had intestinal amebiasis by antigen assays, compared with 2 of 309 (0.2%) who were seronegative (odds ratio [OR], 307; 95% confidence interval [CI], 64.9, 1,451). 21Therefore, those who were seronegative for E. histolytica were not requested to submit stool specimens while counseling for amebiasis was provided.Amebiasis is a reportable disease in Taiwan. Those persons diagnosed with amebiasis will be reported to Centers for Disease Control, Taiwan and treatment with metronidazole 500 mg thrice daily for 7-10 days followed by luminal agents (iodoquinol or paromomycin) to eradicate intestinal carriage. Three consecutive stool specimens were collected 1 week after completion of luminal agents and were subjected to specific amoebic antigen assays. To prevent further transmission of E. histolytica , we encourage the persons with amebiasis to contact their identifiable sexual partners and examinations and treatment of amebiasis will be provided free of charge as well.Case and control. A case of amebiasis was defined as presence of an IHA titer of ³ _ 128. Four control subjects who were seronegative for E. histolytica infection were selected for each case and matched only for date when the case subject sought VCT: two controls before and two controls after the date. Because higher IHA titers may persist for a certain period of time, only t...

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Amebic Liver Abscess in HIV-infected Patients, Republic of Korea

Cited by 57 publications

References 10 publications

Invasive Amebiasis in Men Who Have Sex with Men, Australia

Invasive Amebiasis in Men Who Have Sex with Men, Australia

Seroprevalence of Entamoeba histolytica Infection among Men Who Have Sex with Men in Sydney, Australia

Amebiasis among Persons Who Sought Voluntary Counseling and Testing for Human Immunodeficiency Virus Infection: A Case-Control Study

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