Amelanotic malignant melanoma arising in an ovarian dermoid cyst

Borup, K; Rasmussen, Kirsten; Schierup, L; Möller, Jens

doi:10.3109/00016349209009928

Cited by 17 publications

(8 citation statements)

References 12 publications

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“…Only 19 cases of malignant melanoma arising in an ovarian cystic teratoma have been reported, to our knowledge, and only 2 of these were amelanotic. 2,3 In reviewing 2,500 cases of malignant melanoma, Konatadoulakis et al 4 pointed out that malignant melanomas of the female genital tract represent only some 1% of ovarian tumors. The most common site of genital malignant melanoma is the vagina (5.2% of melanomas), followed by the vulva (4.4%).…”

Section: Discussionmentioning

confidence: 99%

Amelanotic Malignant Melanoma Arising in an Ovarian Cystic Teratoma

Watanabe

Ueda²,

Nakajima³

et al. 2001

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Amelanotic Malignant Melanoma Arising in an Ovarian Cystic Teratoma

Watanabe

Ueda²,

Nakajima³

et al. 2001

Acta Cytologica

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“…Carcinoid seems to be described as frequently as in the testis [51]. Extremely rare in the ovaries and never observed in the testis are one amelanotic malignant melanoma [52], a chordoma [53], and two glioblastomas [54].…”

Section: Comparison Of Testicular and Ovarian Teratomasmentioning

confidence: 99%

Teratoma with somatic-type malignant components of the testis. A review and an update

Mikuz

Colecchia

2012

Virchows Arch

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Malignant transformation of germ cell tumors into somatic malignancy is uncommon. Its presentation differs from series to series, with 43 % of adult cases identified within the primary tumors and the remainder at the time of relapse or in the metastasis. Patients with stage I disease enjoy an excellent prognosis; whereas in metastatic sites when not completely resectable, the somatic type malignancies suffer a dismal prognosis. Radical surgery is significant for the prospects of cure and is standard chemotherapy for germ cell tumors; a transformation-oriented treatment can be effective for these patients. A deeper understanding of the biology of this phenomenon is essential for clinicians involved in such malignancies in order to permit a better control of the disease.

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“…6 To date, only 46 cases have been reported in the literature, of which one report is a compilation of 20 cases. [1][2][3][4][8][9][10][11][12] Differentiation of primary from metastatic melanoma in the ovary is challenging for pathologists.…”

Section: Discussionmentioning

confidence: 98%

“…The most-common histology is squamous-cell carcinoma (88%), followed by adenocarcinoma (7%), and melanoma (which is very rare). [1][2][3][4][5][6] Case A 58-year-old woman presented with a history of dull aching pain and progressive abdominal distension of 2 months' duration. There was no history of any suspicious pigmented skin lesions or surgery for any such skin lesions in her past.…”

Section: Introductionmentioning

confidence: 99%

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

Hulikal

BanothManilal

GangasaniRevanth

et al. 2015

Journal of Gynecologic Surgery

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Background: Primary melanoma of the ovary is very rare; fewer than 50 cases have been reported to date. The diagnosis is challenging and is usually one of exclusion of the more-common metastatic diseases. This article describes such a case in detail and reviews relevant literature. Case: A 58-year-old perimenopausal woman presented with a 2-month history of pain and distension of the abdomen. On evaluation, she was found to have bilateral ovarian complex cysts with ascites. In view of her elevated CA 125 level and positive ascitic fluid cytology, she underwent a staging laparotomy. The final histopathology was reported as a malignant melanoma of the left ovary within a cystic teratoma with metastatic involvement of the right ovary, peritoneum, omentum, and mesentery. Results: Following surgery, this patient was evaluated with a whole body F18 flourodeoxyglucose positron emission tomography/computed tomography scan to look for any probable site of primary or other metastatic areas that had not revealed any other sites of disease. She was referred to the medical oncology services of the Sri Venkateswara Institute of Medical Sciences, in Tirupathi, Chittoor District, AP, India, for further treatment. As of this writing, she had completed two cycles of temozolomide chemotherapy with few side-effects. Conclusions: Primary malignant melanoma of the ovary is difficult to diagnose without a component of teratoma. Even with teratomatous elements, this is a diagnosis that involves excluding more-common metastatic disease from a more-common cutaneous primary. ( J GYNECOL SURG 31:166)

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Amelanotic malignant melanoma arising in an ovarian dermoid cyst

Abstract: Malignant transformation occurs in about 2% only of ovarian dermoid cysts. The clinical and histopathological findings in a rare case of primary ovarian malignant melanoma of amelanotic type are presented.

Cited by 17 publications

References 12 publications

Amelanotic Malignant Melanoma Arising in an Ovarian Cystic Teratoma

Amelanotic Malignant Melanoma Arising in an Ovarian Cystic Teratoma

Teratoma with somatic-type malignant components of the testis. A review and an update

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

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