2000
DOI: 10.1046/j.1365-2230.2000.00716.x
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Amelanotic malignant melanoma following cryosurgery for atypical lentigo maligna

Abstract: Cryosurgery is an alternative treatment option to surgical excision for lentigo maligna. Clinical evidence of recurrence is usually characterized by repigmentation at the treated site. We report two patients who developed amelanotic malignant melanoma following cryosurgery for a pigmented lentigo maligna. These cases illustrate the potential risk of treating lentigo maligna with cryosurgery.

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Cited by 22 publications
(11 citation statements)
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“…Cryotherapy 9 is advocated despite reports of malignant melanoma arising after apparent clearance following LM cryotherapy. 10 The presence of malignant melanocyte migration deep into follicles invalidates techniques such as laser destruction and dermabrasion that involve superficial skin removal followed by re-epithelialization. In effect, surgical full-thickness skin removal is the only logical surgical option because of the need to remove skin adnexal structures.…”
Section: What Does This Study Add?mentioning
confidence: 99%
See 1 more Smart Citation
“…Cryotherapy 9 is advocated despite reports of malignant melanoma arising after apparent clearance following LM cryotherapy. 10 The presence of malignant melanocyte migration deep into follicles invalidates techniques such as laser destruction and dermabrasion that involve superficial skin removal followed by re-epithelialization. In effect, surgical full-thickness skin removal is the only logical surgical option because of the need to remove skin adnexal structures.…”
Section: What Does This Study Add?mentioning
confidence: 99%
“…1 The 10-50% incidence of invasive disease present in excised LM specimens suggests that in many cases invasive disease is not clinically apparent, 2-5 but presumably would become evident if the patient lived long enough. 10 The presence of malignant melanocyte migration deep into follicles invalidates techniques such as laser destruction and dermabrasion that involve superficial skin removal followed by re-epithelialization. Complete surgical excision is generally preferred, although other therapies and watchful waiting may be pragmatic in frail, elderly patients.…”
mentioning
confidence: 99%
“…Good responses have been reported after radiotherapy, although subsequent skin changes can be problematic . The development of amelanotic malignant melanoma following cryotherapy in two cases has reduced interest in this technique . Other topical agents include 5% fluorouracil, 2,4‐dinitrochlorobenzene, tretinoin and azelaic acid …”
Section: Introductionmentioning
confidence: 99%
“…Micrographic surgery and use of immunohistochemistry can reduce this number. However, in lesions less than 0.75 mm in thickness, the supposed microinvasion would not alter the prognosis [20,21].…”
Section: Discussionmentioning
confidence: 99%