Amelanotic subungual melanoma after trauma: An unusual clinical presentation

Rangwala, Sophia; Hunt, Christine; Modi, Gaurang; Krishnan, Bhuvaneswari; Orengo, Ida

doi:10.5070/d37gc0p4n1

Cited by 15 publications

(3 citation statements)

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“…Its etiology, pathogenesis and natural history, remain poorly understood. Trauma appears to be a frequently reported event, though some authors consider it incidental (1)(2)(3)(4). The patient denied any traumatic injury or infection and was otherwise healthy.…”

Section: Discussionmentioning

confidence: 96%

A Gray Pigmented Band of the Third Fingernail With Distal Splitting

2014

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Section: Discussionmentioning

confidence: 96%

A Gray Pigmented Band of the Third Fingernail With Distal Splitting

2014

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“…Trauma does not necessarily lead to AM development, but its effects on AM cannot be ignored. Although there is no clear statistical evidence, the relationship between trauma and the development of nail apparatus melanoma (NAM) is agreed upon by most researchers [8][9][10]. Some studies have even suggested that trauma has a much greater impact on NAM than AM since NAM occurs more often in the thumb or big toe (75-90%), which are more susceptible to trauma [11].…”

Section: Clinical Characteristicsmentioning

confidence: 99%

Clinical features, molecular pathology, and immune microenvironmental characteristics of acral melanoma

Gui

Zhang

2022

J Transl Med

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Acral melanoma (AM) has unique biology as an aggressive subtype of melanoma. It is a common subtype of melanoma in races with darker skin tones usually diagnosed at a later stage, thereby presenting a worse prognosis compared to cutaneous melanoma. The pathogenesis of acral melanoma differs from cutaneous melanoma, and trauma promotes its development. Compared to cutaneous melanomas, acral melanomas have a significantly lighter mutational burden with more copy number variants. Most acral melanomas are classified as triple wild-type. In contrast to cutaneous melanomas, acral melanomas have a suppressive immune microenvironment. Herein, we reviewed the clinical features, genetic variants, and immune microenvironmental characteristics of limbic melanomas to summarise their unique features.

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“…The relationship between trauma and cutaneous melanoma has been debatable. Several case reports have indi-cated the development of melanoma after trauma exposure, and the incidence of trauma in the literature ranged from 15% to 64.5% [11][12][13][14][15][16]. However, some authors are skeptical about this relationship because they could not find sufficient statistical evidence to conclude that trauma is a causative factor for melanoma development [17,18].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic Characteristics of Trauma-Related Nail Apparatus Melanoma: A Comparative Study according to the Presence of Trauma prior to Melanoma Development

Choi¹,

Cho²,

Won³

et al. 2022

Dermatology

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Background: Nail apparatus melanoma (NAM) is a subtype of cutaneous melanoma occurring at nail units and belongs to the acral lentiginous melanoma subgroup. Due to its unique anatomical structure to protect the acral site, mechanical trauma may have a clinicoprognostic impact on NAM. Therefore, we investigated the clinicoprognostic and histopathological characteristics of NAM according to the presence of trauma history prior to melanoma development. Methods: Clinicopathological and follow-up data of patients with NAM according to trauma history were obtained. Results: We included 87 patients with NAM, 21.8% of whom had a previous trauma history. Trauma-related NAMs were more likely to involve the toenail (p = 0.040), include a high proportion of amelanotic melanomas (p = 0.038) as well as nail bed tumor (p = 0.013), and have a longer time interval between the onset of nail change and confirmed diagnosis (p = 0.012). Moreover, survival analysis revealed that trauma-related NAMs more frequently showed progression in general (p = 0.034) and nodal metastasis (p = 0.047) and had worse prognosis in terms of progression-free survival (p = 0.004). Conclusion: In conclusion, NAMs with previous trauma have unique clinicoprognostic characteristics. The specific clinicopathological features of NAMs according to trauma indicate that trauma may play a role in melanoma development.

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Amelanotic subungual melanoma after trauma: An unusual clinical presentation

Cited by 15 publications

References 0 publications

A Gray Pigmented Band of the Third Fingernail With Distal Splitting

A Gray Pigmented Band of the Third Fingernail With Distal Splitting

Clinical features, molecular pathology, and immune microenvironmental characteristics of acral melanoma

Clinicopathologic Characteristics of Trauma-Related Nail Apparatus Melanoma: A Comparative Study according to the Presence of Trauma prior to Melanoma Development

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